Apolipoprotein E ε4 status modifies the effects of sex hormones on neuropsychiatric symptoms of Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 33, Issue 1, 2012, Pages 35-42

  Xing, Yi ^a,b   Qin, Wei ^a,b   Li, Fang ^a,b   Jia, Xiang Fei ^c   Jia, Jianping ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Alzheimer's disease; Apolipoprotein E 4; Gonadal steroid hormones; Neuropsychiatry

Indexed keywords

APOLIPOPROTEIN E4; ESTRADIOL; TESTOSTERONE;

AGED; AGGRESSION; AGITATION; ALLELE; ALZHEIMER DISEASE; ANXIETY DISORDER; APATHY; APPETITE DISORDER; ARTICLE; BIOAVAILABILITY; CORRELATIONAL STUDY; DEPRESSION; ESTRADIOL BLOOD LEVEL; EUPHORIA; FEMALE; GENOTYPE; HALLUCINATION; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; NEUROPATHY; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PSYCHOPATHY; SEX DIFFERENCE; SLEEP DISORDER; TESTOSTERONE BLOOD LEVEL;

AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; CHINA; EDUCATIONAL STATUS; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; HALLUCINATIONS; HUMANS; LOGISTIC MODELS; MALE; MENTAL DISORDERS; PSYCHOMOTOR AGITATION; RISK FACTORS; SEX FACTORS; TESTOSTERONE;

EID: 84857704662     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000336600     Document Type: Article

References (36)

1. Wetzels RB, Zuidema SU, de Jonghe JF, Verhey FR, Koopmans RT: Determinants of quality of life in nursing home residents with dementia. Dement Geriatr Cogn Disord 2010;29:189-197.
2. Matsui T, Nakaaki S, Murata Y, Sato J, Shinagawa Y, Tatsumi H, Furukawa TA: Determinants of the quality of life in Alzheimer's disease patients as assessed by the Japanese version of the Quality of Life-Alzheimer's disease scale. Dement Geriatr Cogn Disord 2006;21:182-191. (Pubitemid 43201329)
3. Tun SM, Murman DL, Long HL, Colenda CC, von Eye A: Predictive validity of neuropsychiatric subgroups on nursing home placement and survival in patients with Alzheimer disease. Am J Geriatr Psychiatry 2007;15:314-327.
4. Sternbach H: Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry 1998;155:1310-1318.
5. Seeman MV: Psychopathology in women and men: focus on female hormones. Am J Psychiatry 1997;154:1641-1647.
6. Craig MC, Murphy DG: Estrogen: effects on normal brain function and neuropsychiatric disorders. Climacteric 2007;10(suppl 2):97-104. (Pubitemid 47450834)
7. Orengo C, Kunik ME, Molinari V, Wristers K, Yudofsky SC: Do testosterone levels relate to aggression in elderly men with dementia? J Neuropsychiatry Clin Neurosci 2002;14:161-166.
8. Carlson LE, Sherwin BB, Chertkow HM: Relationships between mood and estradiol (E2) levels in Alzheimer's disease (AD) patients. J Gerontol B Psychol Sci Soc Sci 2000;55:P47-P53.
9. Shelton PS, Brooks VG: Estrogen for dementia-related aggression in elderly men. Ann Pharmacother 1999;33:808-812. (Pubitemid 29387660)
10. Kyomen HH, Nobel KW, Wei JY: The use of estrogen to decrease aggressive physical behavior in elderly men with dementia. J Am Geriatr Soc 1991;39:1110-1112.
11. Kay SR, Yurkow J, Forman L, Chopra A, Cavelieri T: Transdermal estradiol in the management of aggressive behaviors in male patients with dementia. Clin Gerontol 1995;15:54-58.
12. Valen-Sendstad A, Engedal K, Stray-Pedersen B, Strobel C, Barnett L, Meyer N, Nurminemi M: Effects of hormone therapy on depressive symptoms and cognitive functions in women with Alzheimer disease: a 12-month randomized, double-blind, placebo-controlled study of low-dose estradiol and norethisterone. Am J Geriatr Psychiatry 2010;18:11-20.
13. Fernandes LH, Scassellati-Sforzolini B, Spaide RF: Estrogen and visual hallucinations in a patient with Charles Bonnet syndrome. Am J Ophthalmol 2000;129:407. (Pubitemid 30126103)
14. Ready RE, Friedman J, Grace J, Fernandez H: Testosterone deficiency and apathy in Parkinson's disease: a pilot study. J Neurol Neurosurg Psychiatry 2004;75:1323-1326. (Pubitemid 39141342)
15. Berglund LH, Prytz HS, Perski A, Svartberg J: Testosterone levels and psychological health status in men from a general population: the Tromso study. Aging Male 2011;14:37-41.
16. Almeida OP, Lautenschlager N, Vasikaram S, Leedman P, Flicker L: Association between physiological serum concentration of estrogen and the mental health of community-dwelling postmenopausal women age 70 years and over. Am J Geriatr Psychiatry 2005;13:142-149. (Pubitemid 41031103)
17. van der Flier WM, Staekenborg S, Pijnenburg YA, Gillissen F, Romkes R, Kok A, Bouwman FH, Scheltens P: Apolipoprotein E genotype influences presence and severity of delusions and aggressive behavior in Alzheimer disease. Dement Geriatr Cogn Disord 2007;23:42-46. (Pubitemid 46005790)
18. Panza F, Frisardi V, Seripa D, D'Onofrio G, Santamato A, Masullo C, Logroscino G, Solfrizzi V, Pilotto A: Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's disease. Ageing Res Rev 2012;11:87-103.
19. Zofkova I, Zajickova K, Hill M, Horinek A: Apolipoprotein E gene determines serum testosterone and dehydroepiandrosterone levels in postmenopausal women. Eur J Endocrinol 2002;147:503-506. (Pubitemid 35238146)
20. Hogervorst E, Lehmann DJ, Warden DR, McBroom J, Smith AD: Apolipoprotein E epsilon4 and testosterone interact in the risk of Alzheimer's disease in men. Int J Geriatr Psychiatry 2002;17:938-940. (Pubitemid 35189620)
21. Wang PN, Liu HC, Liu TY, Chu A, Hong CJ, Lin KN, Chi CW: Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease. Dement Geriatr Cogn Disord 2005;19:120-125. (Pubitemid 40868038)
22. Burkhardt MS, Foster JK, Clarnette RM, Chubb SA, Bruce DG, Drummond PD, Martins RN, Yeap BB: Interaction between testosterone and apolipoprotein E epsilon4 status on cognition in healthy older men. J Clin Endocrinol Metab 2006;91:1168-1172. (Pubitemid 43357796)
23. Yaffe K, Haan M, Byers A, Tangen C, Kuller L: Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology 2000;54:1949-1954.
24. Burkhardt MS, Foster JK, Laws SM, Baker LD, Craft S, Gandy SE, Stuckey BG, Clarnette R, Nolan D, Hewson-Bower B, Martins RN: Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. J Alzheimers Dis 2004;6:221-228. (Pubitemid 38823256)
25. Folstein MF, Folstein SE, McHugh PR: 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
26. Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412-2414.
27. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314. (Pubitemid 24382728)
28. Tsai MS, Tangalos EG, Petersen RC, Smith GE, Schaid DJ, Kokmen E, Ivnik RJ, Thibodeau SN: Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet 1994;54:643-649. (Pubitemid 24089603)
29. Vermeulen A, Verdonck L, Kaufman JM: A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-3672. (Pubitemid 30645223)
30. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW: Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 2000;85:3276-3282.
31. Rosin RA, Raskind MA: Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report. Int Psychogeriatr 2005;17:313-318. (Pubitemid 41073174)
32. Kang JH, Grodstein F: Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline. Neurobiol Aging 2010, E-pub ahead of print.
33. Chang JB, Wang PN, Chen WT, Liu CY, Hong CJ, Lin KN, Liu TY, Chi CW, Liu HC: ApoE epsilon4 allele is associated with incidental hallucinations and delusions in patients with AD. Neurology 2004;63:1105-1107. (Pubitemid 39287928)
34. Gabryelewicz T, Religa D, Styczynska M, Peplonska B, Pfeffer A, Wasiak B, Luczywek E, Golebiowski M, Androsiuk W, Czyzewski K, Przekop I, Barcikowska M: Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype. Dement Geriatr Cogn Disord 2002;14:208-212. (Pubitemid 36151488)
35. Muller-Thomsen T, Arlt S, Ganzer S, Mann U, Mass R, Naber D, Beisiegel U: Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. Dement Geriatr Cogn Disord 2002;14:59-63. (Pubitemid 36152946)
36. Kley HK, Schlaghecke R, Kruskemper HL: Stability of steroids in plasma over a 10-year period. J Clin Chem Clin Biochem 1985;23:875-878. (Pubitemid 16171434)