Magnoflorine from Tinospora cordifolia stem inhibits α-glucosidase and is antiglycemic in rats

Journal of Functional Foods

Volumn 4, Issue 1, 2012, Pages 79-86

  Patel, Mayurkumar B ^a   Mishra, Shrihari M ^b  

^a Atmiya Institute of Pharmacy   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Glucosidase inhibition; Isoqionoline alkaloids; Magnoflorine; Tinospora cordifolia

Indexed keywords

RATTUS; TINOSPORA CORDIFOLIA;

EID: 84857691579     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2011.08.002     Document Type: Article

References (27)

1. Barbosa-Filho J.M., Da-Cunha E.V.L., Corni-Lio M.L., Dias C.D.S., Gray A.I. Cissaglaberrimine, An aporphine alkaloid from Cissampelos glaberrima. Phytochemistry 1997, 44:959-961.
2. Bisset N.G., Nwaiwu J. Quaternary alkaloids of Tinospora species. Planta Medica 1983, 48:275-279.
3. Dahlqvist A. Method for assay of intestinal disaccharidases. Anaytical Biochemistry 1964, 7:18-25.
4. Davis S.N., Granner D.K. Insulin: Goodman and Gilman's the pharmacological basis of therapeutics 1996, McGraw-Hill, New York, (pp. 1487-1517). 9th ed.
5. Dhaliwal, K. S. (1999). Method and composition for treatment of diabetes. US Patent 5886029.
6. Gangan V.D., Pradhan P., Sipahimalani A.T., Banerji A. Cordifolisides A, B, C: Norditerpene furan glycosides from Tinospora cordifolia. Phytochemistry 1994, 37:781-786.
7. Grover J.K., Vats V., Rathi S.S. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. Journal of Ethnopharmacology 2000, 73:461-470.
8. Grover J.K., Vats V., Rathi S.S., Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. Journal of Ethnopharmacology 2001, 76:233-238.
9. Grover J.K., Yadav S., Vats V. Medicinal plants of India with anti-diabetic potential. Journal of Ethnopharmacology 2002, 81:81-100.
10. Gupta S.S., Varma S.C.L., Garg V.P., Rai M. Antidiabetic effect of Tinospora cordifolia. I. Effect on fasting blood sugar level, glucose tolerance and adrenaline induced hyperglycemia. Indian Journal of Experimental Biology 1967, 55:733-745.
11. Hawley S.A., Gadalla A.E., Olsen G.S., Hardie D.G. The anti-diabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002, 51:2420-2425.
12. Kameswara R.B., Kesavulu M.M., Giri R., Appa R.C. Anti-diabetic and hypolipidemic effects of Momordica cymbalaria Hook fruit powder in alloxan-diabetic rats. Journal of Ethnopharmacology 1999, 67:103-109.
13. Keawpradub N., Dej-Adisai S., Yuenyongsawad S. Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria. Songklanakarin Journal of Science and Technology 2005, 27:455-467.
14. Kumar S., Verma N.S., Pande D., Srivastava P.S. In vitro regeneration and screening of berberine in Tinospora cordifolia. Journal of Medicinal and Aromatic Plant Sciences 2000, 22:61.
15. +-glucose co-transporter by naringenin. The International Journal of Biochemistry and Cell Biology 2006, 38:985-995.
16. Mahajan V.R., Jolly C.I. A new hypoglyceamic agent from Tinospora cordifolia Miers. Indian Drugs 1985, 23:119-120.
17. Matsui T., Ebuchi S., Kobayashi M., Fukui K., Sugita K., Terahara N., et al. Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. Journal of Agricultural and Food Chemistry 2002, 50:7244-7248.
18. Ortiz-Andrade R.R., Rodríguez-López V., Garduño-Ramírez M.L., Castillo-España P., Estrada-Soto S. Anti-diabetic effect on alloxanized and normoglycemic rats and some pharmacological evaluations of Tournefortia hartwegiana. Journal of Ethnopharmacology 2005, 101:37-42.
19. Pachaly P., Schneider C. Alkaloids from Tinospora cordifolia Miers. Archives of Pharmacology 1981, 314:251-256.
20. Padhya M.A. Biosynthesis of isoquinoline alkaloid berberine in tissue cultures of Tinospora cordifolia. Indian Drugs 1986, 24:47-48.
21. Qudrat-I-Khuda M., Khaleque A., Ray N. Tinospora cordifolia. I. Constituents of the plant fresh from the field. Journal of Scientific Research 1964, 1:177-183.
22. Raghunathan K., Sharma P.V. The aqueous extract of T. cordifolia caused reduction of blood sugar in alloxan induced hyperglycemic rats and rabbits. Journal of Research in Indian Medicine 1969, 3:203-209.
23. Sarma D.N.K., Khosa R.L., Sahai M. Isolation of Jatrorrhizine from Tinospora cordifolia roots. Planta Medica 1995, 61:98-99.
24. Sarma D.N.K., Padma P., Khosa R.L. Constituents of Tinospora cordifolia root. Fitoterapia 1998, 69:541-542.
25. Shim Y.J., Doo H.K., Ahn S.Y., Kim Y.S., Seong J.K., Park I.S., et al. Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. Journal of Ethnopharmacology 2003, 85:283-287.
26. Stanely M., Prince P., Menon V.P. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan induced diabetic rats. Journal of Ethnopharmacology 2000, 70:9-15.
27. Wadood N., Wadood A., Shah S.A. Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits. Planta Medica 1998, 58:131-136.