Design and validation of a compressive tissue stimulator with high-throughput capacity and real-time modulus measurement capability

Tissue Engineering - Part C: Methods

Volumn 18, Issue 3, 2012, Pages 205-214

  Salvetti, David J ^a   Pino, Christopher J ^a   Manuel, Steven G ^a   Dallmeyer, Ian ^a   Rangarajan, Sanjeet V ^a   Meyer, Tobias ^a   Kotov, Misha ^a   Shastri, V Prasad ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCERAMICS; BONE; CARTILAGE; ELASTIC MODULI; ELASTICITY; SENSORS; TISSUE; TISSUE CULTURE; TISSUE ENGINEERING;

AGAROSE; CANCELLOUS BONE; COMPLEX VARIABLE; CULTURE CONDITIONS; EX-VIVO; FORCE SENSOR; HIGH-THROUGHPUT; HYALINE CARTILAGE; KEY PARAMETERS; LINEAR ENCODERS; LOAD CELLS; MAXIMIZE THROUGHPUT; MECHANICAL CHARACTERISTICS; MECHANICAL STIMULATION; MODULUS MEASUREMENTS; OSTEOCHONDRAL TISSUES; REAL-TIME CHANGES; SOFT GELS; TISSUE CONSTRUCTS; TISSUE CULTURE PLASTICS; YOUNG'S MODULUS;

DESIGN;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CALIBRATION; CARTILAGE; CHEMISTRY; COMPRESSIVE STRENGTH; COMPUTER PROGRAM; COMPUTER SYSTEM; CYTOLOGY; ELASTICITY; GENETIC PROCEDURES; HIGH THROUGHPUT SCREENING; INSTRUMENTATION; MATERIALS TESTING; MECHANICAL STRESS; METHODOLOGY; PHYSIOLOGY; STANDARD; SWINE; TISSUE ENGINEERING; VALIDATION STUDY; YOUNG MODULUS;

ALGORITHMS; ANIMALS; BIOSENSING TECHNIQUES; CALIBRATION; CARTILAGE; COMPRESSIVE STRENGTH; COMPUTER SYSTEMS; ELASTIC MODULUS; ELASTICITY; HIGH-THROUGHPUT SCREENING ASSAYS; MATERIALS TESTING; MODELS, BIOLOGICAL; SOFTWARE; STRESS, MECHANICAL; SWINE; TISSUE ENGINEERING; WEIGHTS AND MEASURES;

EID: 84857673884     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0233     Document Type: Article

References (21)

1. Blunk, T., Sieminski, A.L., Gooch, K.J., Courter, D.L., Hollander, A.P., Nahir, A.M., Langer, R., Vunjak-Novakovic, G., and Freed, L.E. Differential effects of growth factors on tissue-engineered cartilage. Tissue Eng 8, 73, 2002.
2. Gooch, K.J., Blunk, T., Courter, D.L., Sieminski, A.L., Vunjak- Novakovic, G., and Freed, L.E. Bone morphogenetic proteins- 2, - 12, and - 13 modulate in vitro development of engineered cartilage. Tissue Eng 8, 591, 2002.
3. Gooch, K.J., Blunk, T., Courter, D.L., Sieminski, A.L., Bursac, P.M., Vunjak-Novakovic, G., and Freed, L.E. IGF-I and mechanical environment interact to modulate engineered cartilage development. Biochem Biophys Res Commun 286, 909, 2001.
4. Darling, E.M., and Athanasiou, K.A. Biomechanical strategies for articular cartilage regeneration. Ann Biomed Eng 31, 1114, 2003.
5. Grodzinsky, A.J., Levenston, M.E., Jin, M., and Frank, E.H. Cartilage tissue remodeling in response to mechanical forces. Annu Rev Biomed Eng 2, 691, 2000.
6. Lee, C., Grad, S., and Wimmer, M.A. The influence of mechanical stimuli on articular cartilage tissue engineering. In: Ashammakhi, N., and Reis, R.I., eds. Topics in Tissue Engineering. Oulu, Finland: Expertissues, 2006, pp. 1-32.
7. Bonassar, L.J., Grodzinsky, A.J., Frank, E.H., Davila, S.G., Bhaktav, N.R., and Trippel, S.B. The effect of dynamic compression on the response of articular cartilage to insulinlike growth factor-I. J Orthop Res 19, 11, 2001.
8. Darling, E.M., and Athanasiou, K.A. Articular cartilage bioreactors and bioprocesses. Tissue Eng 9, 9, 2003.
9. Portner, R., Nagel-Heyer, S., Goepfert, C., Adamietz, P., and Meenen, N.M. Bioreactor design for tissue engineering. J Biosci Bioeng 100, 235, 2005.
10. Aufderheide, A.C., and Athanasiou, K.A. A direct compression stimulator for articular cartilage and meniscal explants. Ann Biomed Eng 34, 1463, 2006.
11. Demarteau, O., Jakob, M., Schafer, D., Heberer, M., and Martin, I. Development and validation of a bioreactor for physical stimulation of engineered cartilage. Biorheology 40, 331, 2003.
12. Mauck, R.L., Soltz, M.A., Wang, C.C.B., Wong, D.D., Chao, P.H.G., Valhmu, W.B., Hung, C.T., and Ateshian, G.A. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng-Trans Asme 122, 252, 2000.
13. Chen, H.C., and Hu, Y.C. Bioreactors for tissue engineering. Biotechnol Lett 28, 1415, 2006.
14. Lujan, T.J., Wirtz, K.M., Bahney, C.S., Madey, S.M., Johnstone, B., and Bottlang, M. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C: Methods 17, 367, 2011.
15. Stevens, M.M., Qanadilo, H.F., Langer, R., and Shastri, V.P. A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering. Biomaterials 25, 887, 2004.
16. Vunjak-Novakovic, G., and Freshney, R.I., eds. Culture of Cells for Tissue Engineering. New York: Wiley & Sons, 2006.
17. Stolz, M., Raiteri, R., Daniels, A.U., VanLandingham, M.R., Baschong, W., and Aebi, U. Dynamic elastic modulus of porcine articular cartilage determined at two different levels of tissue organization by indentation-type atomic force microscopy. Biophys J 86, 3269, 2004.
18. Cowin, S.C., ed. Bone Mechanics Handbook. Boca Raton, Florida: CRC Press, 2001.
19. Mackenzie, J.K. Elastic constants of a solid containing spherical holes. Proc Phys Soc (London) 63B, 2, 1950.
20. Gupta, R., Naranja, R.J., Levitz, C.I., and Brighton, C.T. The biochemical pathway of capacitively coupled electrical field stimulation of osteoblast-like cells. Proceedings of the 14th Annual Society for Physical Regulation in Biology and Medicine. New York: Society for Physical Regulation in Biology and Medicine. 1, 1994.
21. Korenstein, R., Somjen, D., Fischler, H., and Binderman, I. Capacitative pulsed electric-stimulation of bone-cells- induction of cyclic-AMP changes and DNA-synthesis. Biochim Biophys Acta 803, 302, 1984.