Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 4, 2012, Pages 647-653

  Spanova, Miroslava ^a   Zweytick, Dagmar ^b   Lohner, Karl ^b   Klug, Lisa ^a   Leitner, Erich ^c   Hermetter, Albin ^a   Daum, Günther ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Ergosterol; Fluidity; Lipid droplet; Plasma membrane; Squalene; Yeast

Indexed keywords

CHOLESTEROL ESTER; FAT DROPLET; MEMBRANE LIPID; SQUALENE; TRIACYLGLYCEROL;

ARTICLE; ARTIFICIAL MEMBRANE; CELL MEMBRANE; CELL MEMBRANE FLUIDITY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ENDOPLASMIC RETICULUM; FUNGAL STRAIN; GENE DELETION; HIGH TEMPERATURE; MEMBRANE FLUIDITY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEROL SYNTHESIS;

5-AMINOLEVULINATE SYNTHETASE; CALORIMETRY, DIFFERENTIAL SCANNING; CELL MEMBRANE; CYTOPLASMIC GRANULES; FLUORESCENCE POLARIZATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INTRACELLULAR MEMBRANES; LIPIDS; MEMBRANE FLUIDITY; MEMBRANE LIPIDS; MUTATION; PARTICLE SIZE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SQUALENE; STEROLS; TEMPERATURE; THERMODYNAMICS;

SACCHAROMYCES CEREVISIAE;

EID: 84857673481     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.01.015     Document Type: Article

References (46)

1. Y. Kohno, Y. Egawa, S. Itoh, S. Nagaoka, M. Takahashi, and K. Mukai Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol Biochim. Biophys. Acta 1256 1995 1256, 52-56
2. K.N. Desai, H. Wei, and C.A. Lamartiniere The preventive and therapeutic potential of the squalene-containing compound, Roidex, on tumor promotion and regression Cancer Lett. 101 1996 93 96 (Pubitemid 26060861)
3. T. Ikekawa, M. Umeji, T. Manabe, S. Yanoma, K. Irinoda, H. Mizunuma, and N. Ikekawa Studies on antitumor activity of squalene and its related compounds Yakugaku Zasshi 106 1986 578 582 (Pubitemid 16002847)
4. T.J. Smith Squalene: potential chemopreventive agent Expert Opin. Investig. Drugs 9 2000 1841 1848 (Pubitemid 30639333)
5. O.J. Catchpole, J.C. von Kamp, and J.B. Grey Extraction of squalene from shark liver oil in a packed column using supercritical carbon dioxide Ind. Eng. Chem. Res. 36 1997 4318 4324
6. P. Bondioli, C. Mariani, A. Lanzani, E. Fedeli, and A. Muller Squalene recovery from olive oil deodorizer distillates J. Am. Oil Chem. Soc. 70 1993 763 766 (Pubitemid 23707794)
7. P. Bhattacharjee, and R.S. Singhal Extraction of squalene from yeast by supercritical carbon dioxide World J. Microbiol. Biotechnol. 19 2003 605 608 (Pubitemid 37089996)
8. G.Q. Chen, K.W. Fan, F.P. Lu, Q.A. Li, T. Aki, F. Chen, and Y. Jiang Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp N. Biotechnol. 27 2010 382 389
9. T. Polakowski, U. Stahl, and C. Lang Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast Appl. Microbiol. Biotechnol. 49 1998 66 71 (Pubitemid 28055383)
10. K.A. Donald, R.Y. Hampton, and I.B. Fritz Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae Appl. Environ. Microbiol. 63 1997 3341 3344 (Pubitemid 27383119)
11. L. Jahnke, and H.P. Klein Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae J. Bacteriol. 155 1983 488 492
12. R.T. Lorenz, W.M. Casey, and L.W. Parks Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae J. Bacteriol. 171 1989 6169 6173 (Pubitemid 19266940)
13. M. Spanova, T. Czabany, G. Zellnig, E. Leitner, I. Hapala, and G. Daum Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiae J. Biol. Chem. 285 2010 6127 6133
14. F. Mantzouridou, and M.Z. Tsimidou Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6 FEMS Yeast Res. 10 2010 699 707
15. V.F. Kalb, J.C. Loper, C.R. Dey, C.W. Woods, and T.R. Sutter Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae Gene 45 1986 237 245 (Pubitemid 17202575)
16. M. Bard, N.D. Lees, T. Turi, D. Craft, L. Cofrin, R. Barbuch, C. Koegel, and J.C. Loper Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans Lipids 28 1993 963 967 (Pubitemid 23333690)
17. T. Ferreira, M. Regnacq, P. Alimardani, C. Moreau-Vauzelle, and T. Berges Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion Biochem. J. 378 2004 899 908 (Pubitemid 38406867)
18. S. Reiner, D. Micolod, G. Zellnig, and R. Schneiter A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast Mol. Biol. Cell 17 2006 90 103 (Pubitemid 43049464)
19. A.A. Andreasen, and T.J. Stier Anaerobic nutrition of Saccharomyces cerevisiae. II. Unsaturated fatty acid requirement for growth in a defined medium J. Cell. Physiol. 43 1954 271 281
20. E.G. Gollub, K.P. Liu, J. Dayan, M. Adlersberg, and D.B. Sprinson Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene J. Biol. Chem. 252 1977 2846 2854 (Pubitemid 8096441)
21. M. Bard, R.A. Woods, and J.M. Haslam Porphyrine mutants of Saccharomyces cerevisiae: correlated lesions in sterol and fatty acid biosynthesis Biochem. Biophys. Res. Commun. 56 1974 324 330
22. A.A. Andreasen, and T.J. Stier Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium J. Cell. Physiol. 41 1953 23 36
23. R. Leber, E. Zinser, G. Zellnig, F. Paltauf, and G. Daum Characterization of lipid particles of the yeast, Saccharomyces cerevisiae Yeast 10 1994 1421 1428 (Pubitemid 24347995)
24. T. Czabany, K. Athenstaedt, and G. Daum Synthesis, storage and degradation of neutral lipids in yeast Biochim. Biophys. Acta 1771 2007 299 309 (Pubitemid 46428611)
25. S. Rajakumari, K. Grillitsch, and G. Daum Synthesis and turnover of non-polar lipids in yeast Prog. Lipid Res. 47 2008 157 171
26. T.C. Walther, and R.V. Farese Jr. The life of lipid droplets Biochim. Biophys. Acta 1791 2009 459 466
27. T. Czabany, A. Wagner, D. Zweytick, K. Lohner, E. Leitner, E. Ingolic, and G. Daum Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae J. Biol. Chem. 283 2008 17065 17074
28. P. Milla, K. Athenstaedt, F. Viola, S. Oliaro-Bosso, S.D. Kohlwein, G. Daum, and G. Balliano Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles J. Biol. Chem. 277 2002 2406 2412 (Pubitemid 34953261)
29. B. Blagovic, J. Rupcic, M. Mesaric, and V. Maric Lipid analysis of the plasma membrane and mitochondria of brewer's yeast Folia Microbiol. (Praha) 50 2005 24 30 (Pubitemid 40722159)
30. K. Lohner, G. Degovics, P. Laggner, E. Gnamusch, and F. Paltauf Squalene promotes the formation of non-bilayer structures in phospholipid model membranes Biochim. Biophys. Acta 1152 1993 69 77 (Pubitemid 23299036)
31. T. Hauss, S. Dante, N.A. Dencher, and T.H. Haines Squalane is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier Biochim. Biophys. Acta 1556 2002 149 154 (Pubitemid 35379673)
32. S.A. Simon, L.J. Lis, R.C. MacDonald, and J.W. Kauffman The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure Biophys. J. 19 1977 83 90 (Pubitemid 8125348)
33. L. Sandager, M.H. Gustavsson, U. Ståhl, A. Dahlqvist, E. Wiberg, A. Banas, M. Lenman, H. Ronne, and S. Stymne Storage lipid synthesis is non-essential in yeast J. Biol. Chem. 277 2002 6478 6482 (Pubitemid 34968444)
34. U. Gueldener, J. Heinisch, G.J. Koehler, D. Voss, and J.H. Hegemann A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast Nucleic Acids Res. 30 2002 e23
35. E. Zinser, and G. Daum Isolation and biochemical characterization of organelles from the yeast, Saccharomyces cerevisiae Yeast 11 1995 493 536
36. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
37. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
38. A. Haid, and M. Suissa Immunochemical identification of membrane proteins after sodium dodecyl sulfate-polyacrylamide gel electrophoresis Methods Enzymol. 96 1983 192 205
39. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 226 1957 497 509
40. R.M. Broekhuyse Phospholipids in tissues of the eye. I. Isolation, characterization and quantitative analysis by two-dimensional thin-layer chromatography of diacyl and vinyl-ether phospholipids Biochim. Biophys. Acta 152 1968 307 315
41. R. Schneiter, and G. Daum Analysis of yeast lipids Methods Mol. Biol. 313 2006 75 84
42. M.A. Quail, and S.L. Kelly The extraction and analysis of sterols from yeast Methods Mol. Biol. 53 1996 123 131
43. J.R. Lakowicz Principles of Fluorescence Spectroscopy 1983 Plenum Press New York
44. M. Shinitzky, and Y. Barenholz Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate J. Biol. Chem. 249 1974 2652 2657
45. D. Zweytick, K. Athenstaedt, and G. Daum Intracellular lipid particles of eukaryotic cells Biochim. Biophys. Acta 1469 2000 101 120
46. K. Athenstaedt, D. Zweytick, A. Jandrositz, S.D. Kohlwein, and G. Daum Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae J. Bacteriol. 181 1999 6441 6448 (Pubitemid 29512955)