Acute oral toxicity of nickel compounds

Regulatory Toxicology and Pharmacology

Volumn 62, Issue 3, 2012, Pages 425-432

  Henderson, Rayetta G ^a   Durando, Jennifer ^b   Oller, Adriana R ^a   Merkel, Daniel J ^b   Marone, Palma Ann ^b   Bates, Hudson K ^a  

^a NiPERA Inc   (United States)

^b Product Safety Laboratories   (United States)

Author keywords

Acute toxicity; Bioaccessibility; Bioavailability; Classification; Metal; Nickel; Oral; Rat; REACH; Read across

Indexed keywords

NICKEL ACETATE; NICKEL ACETATE TETRAHYDRATE; NICKEL ASH; NICKEL CHLORIDE; NICKEL CHLORIDE HEXAHYDRATE; NICKEL COMPLEX; NICKEL DIHYDROXIDE; NICKEL FLUORIDE; NICKEL FLUORIDE TETRAHYDRATE; NICKEL HYDROXYCARBONATE; NICKEL MATTES; NICKEL MONOXIDE; NICKEL SUBSULFIDE; NICKEL SULFAMATE TETRAHYDRATE; NICKEL SULFATE; NICKEL SULFATE HEXAHYDRATE; UNCLASSIFIED DRUG;

ACCLIMATIZATION; ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BIOAVAILABILITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; IN VIVO STUDY; LD 50; LIMIT OF DETECTION; MASS SPECTROMETRY; MOUTH DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LETHAL DOSE 50; NICKEL; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS, ACUTE;

MARTES; RATTUS;

EID: 84857662227     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.02.002     Document Type: Article

References (19)

1. EC (European Commission), 2006. Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency.
2. EC (European Commission), 2009a. Commission Regulation (EC) No. 790/2009 Amending, for the Purposes of Its Adaptation to Technical and Scientific Progress, Regulation (EC) No. 1272/2008 of the European Parliament and of the Council on Classification, Labelling and Packaging of Substances and Mixtures.
3. EC (European Commission), 2009b. Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging (CLP) of Substances and Mixtures.
4. ECHA (European Chemicals Agency) Guidance on Information Requirements and Chemical Safety Assessment 2008, ECHA, Helsinki.
5. EURA, (2008-2009). European Union Risk Assessment Report for Nickel Carbonate. Danish Environmental Protection Agency. Risk Assessment for Nickel Carbonate (CAS No. 3333-67-3)(EINECS No. 222-068-2) Prepared in Relation to Council Regulation (EEC) 793-93. , last accessed October 25, 2011. http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/.
6. FDRL (Food & Drug Research Laboratories, Inc.), 1983a. Acute Oral LD50 Study in Rats. Study No. 7702A Nickel Sulfate. FDRL, Waverly, New York.
7. FDRL (Food & Drug Research Laboratories, Inc.), 1983b. Acute Oral LD50 Study in Rats. Study No. 7702C Nickel Hydroxide. FDRL, Waverly, New York.
8. FDRL (Food & Drug Research Laboratories, Inc.), 1983c. Acute Oral LD50 Study in Rats. Study No. 7702E Nickel Carbonate. FDRL, Waverly, New York.
9. FDRL (Food & Drug Research Laboratories, Inc.), 1983d. Acute Oral LD50 Study in Rats. Study No. 7684A Nickel Chloride. FDRL, Waverly, New York.
10. FDRL (Food & Drug Research Laboratories, Inc.), 1983e. Acute Oral LD50 Study in Rats. Study No. 7684B Nickel Oxide Black. FDRL, Waverly, New York.
11. FDRL (Food & Drug Research Laboratories, Inc.), 1983f. Acute Oral LD50 Study in Rats. Study No. 7684C Nickel Oxide Green. FDRL, Waverly, New York.
12. FDRL (Food & Drug Research Laboratories, Inc.), 1983g. Acute Oral LD50 Study in Rats. Study No. 7694E Nickel Subsulfide. FDRL, Waverly, New York.
13. Gad S.C., Cassidy C.D., Aubert N., Spainhour B., Robbe H. Nonclinical vehicle use in studies by multiple routes in multiple species. Int. J. Toxicol. 2006, 25:499-521.
14. Henderson, R.G., Cappellini, D., Seilkop, S., Bates, H., Oller, A., 2012. Oral bioaccessibility testing and read-across hazard assessment of nickel compounds, Reg. Toxicol. Pharmacol, in press, doi:10.1016/j.yrtph.2012.02.005.
15. Nickel Institute, 2011. , last accessed October 20, 2011. http://www.nickelinstitute.org.
16. OECD (Organisation for Economic Co-operation and Development), 2006. OECD Guidelines for the Testing of Chemicals, Test No. 425. OECD, Paris.
17. OECD (Organisation for Economic Co-operation and Development), 2007. OECD Series on Testing and Assessment No. 80, Guidance on Grouping of Chemicals. OECD, Paris.
18. Van Vlack L. The Oxides of Nickel 1980, The International Nickel Company, Inc., New York.
19. Zatka V.J. Verifying the composition of certain commercial nickel compounds. Regul. Toxicol. Pharmacol. 1991, 13:87-98.