Repeated botulinum toxin type A injections for refractory overactive bladder: Medium-term outcomes, safety profile, and discontinuation rates

European Urology

Volumn 61, Issue 4, 2012, Pages 834-839

  Dowson, Christopher ^a,b   Watkins, Jane ^b   Khan, Mohammad S ^a,b   Dasgupta, Prokar ^a,b   Sahai, Arun ^a,b  

^a GUY S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Botulinum toxin A; Discontinuation rates; Idiopathic detrusor overactivity; OnabotulinumtoxinA; Overactive bladder; Repeated injections

Indexed keywords

BOTULINUM TOXIN A; CIPROFLOXACIN;

ADULT; AGED; ARTICLE; BACTERIURIA; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; EPIDIDYMITIS; FEMALE; FLU LIKE SYNDROME; HEART INFARCTION; HUMAN; INTERMITTENT CATHETERIZATION; LIMB WEAKNESS; MAJOR CLINICAL STUDY; MALE; OVERACTIVE BLADDER; PARESTHESIA; PRIORITY JOURNAL; QUALITY OF LIFE; TREATMENT OUTCOME; URGE INCONTINENCE; URINARY FREQUENCY; URINARY TRACT INFECTION; URINARY URGENCY; URINE RETENTION;

ADMINISTRATION, INTRAVESICAL; ADULT; AGED; AGED, 80 AND OVER; BOTULINUM TOXINS, TYPE A; CHI-SQUARE DISTRIBUTION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LINEAR MODELS; LONDON; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; QUALITY OF LIFE; QUESTIONNAIRES; RISK ASSESSMENT; RISK FACTORS; SELF CARE; TIME FACTORS; TREATMENT OUTCOME; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINARY CATHETERIZATION; URODYNAMICS; YOUNG ADULT;

EID: 84857658419     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2011.12.011     Document Type: Article

References (19)

1. A. Sahai, M.S. Khan, and P. Dasgupta Efficacy of botulinum toxin-A for treating idiopathic detrusor overactivity: results from a single center, randomized, double-blind, placebo controlled trial J Urol 177 2007 2231 2236 (Pubitemid 46726400)
2. L. Brubaker, H.E. Richter, and A. Visco Refractory idiopathic urge urinary incontinence and botulinum A injection J Urol 180 2008 217 222
3. M.K. Flynn, C.L. Amundsen, M. Perevich, F. Liu, and G.D. Webster Outcome of a randomized, double-blind, placebo controlled trial of botulinum A toxin for refractory overactive bladder J Urol 181 2009 2608 2615
4. R. Dmochowski, C. Chapple, and V.W. Nitti Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial J Urol 184 2010 2416 2422
5. E. Rovner, M. Kennelly, H. Schulte-Baukloh, J. Zhou, C. Haag-Molkenteller, and P. Dasgupta Urodynamic results and clinical outcomes with intradetrusor injections of onabotulinumtoxinA in a randomized, placebo-controlled dose-finding study in idiopathic overactive bladder Neurourol Urodyn 30 2011 556 562
6. A. Apostolidis, P. Dasgupta, and P. Denys Recommendations on the use of botulinum toxin in the treatment of lower urinary tract disorders and pelvic floor dysfunctions: a European consensus report Eur Urol 55 2009 100 120
7. A. Mangera, K.E. Andersson, and A. Apostolidis Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of Botox (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA) Eur Urol 60 2011 784 795
8. S. Khan, T.M. Kessler, and A. Apostolidis What a patient with refractory idiopathic detrusor overactivity should know about botulinum neurotoxin type a injection J Urol 181 2009 1773 1778
9. A. Sahai, C. Dowson, M.S. Khan, and P. Dasgupta Repeated injections of botulinum toxin-A for idiopathic detrusor overactivity Urology 75 2010 552 558
10. W. Schafer, P. Abrams, and L. Liao Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies Neurourol Urodyn 21 2002 261 274 (Pubitemid 34411846)
11. M. Harper, R.B. Popat, R. Dasgupta, C.J. Fowler, and P. Dasgupta A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivity BJU Int 92 2003 325 326 (Pubitemid 36966603)
12. A. Sahai, V. Kalsi, M.S. Khan, and C.J. Fowler Techniques for the intradetrusor administration of botulinum toxin BJU Int 97 2006 675 678 (Pubitemid 43383492)
13. J.J. Wyndaele, and S.A. Van Dromme Muscular weakness as side effect of botulinum toxin injection for neurogenic detrusor overactivity Spinal Cord 40 2002 599 600 (Pubitemid 35305668)
14. G. Del Popolo, M.T. Filocamo, and V. Li Marzi Neurogenic detrusor overactivity treated with English botulinum toxin A: 8-year experience of one single centre Eur Urol 53 2008 1013 1020 (Pubitemid 351434489)
15. A. Giannantoni, E. Mearini, M. Del Zingaro, and M. Porena Six-year follow-up of botulinum toxin A intradetrusorial injections in patients with refractory neurogenic detrusor overactivity: clinical and urodynamic results Eur Urol 55 2009 705 712
16. J. Grosse, G. Kramer, and M. Stöhrer Success of repeat detrusor injections of botulinum A toxin in patients with severe neurogenic detrusor overactivity and incontinence Eur Urol 47 2005 653 659 (Pubitemid 40521915)
17. C. Dowson, M.S. Khan, P. Dasgupta, and A. Sahai Repeat botulinum toxin-A injections for treatment of adult detrusor overactivity Nat Rev Urol 7 2010 661 667
18. T.M. Kessler, S. Khan, J. Panicker, A. Roosen, S. Elneil, and C.J. Fowler Clean intermittent self-catheterization after botulinum neurotoxin type A injections: short-term effect on quality of life Obstet Gynecol 113 2009 1046 1051
19. A. Sahai, M.S. Khan, G.N. Le, and P. Dasgupta Urodynamic assessment of poor responders after botulinum toxin-A treatment for overactive bladder Urology 71 2008 455 459 (Pubitemid 351374741)