Toxicological evaluation of smokeless tobacco: 90-Day rodent feeding studies

Experimental and Toxicologic Pathology

Volumn 64, Issue 1-2, 2012, Pages 15-24

  Theophilus, Eugenia H ^a   Hayes, Johnnie R ^a   Potts, Ryan J ^a   Ayres, Paul H ^a   Williams, Chandra D ^a   Garner, Charles D ^a  

^a R J REYNOLDS TOBACCO COMPANY   (United States)

Author keywords

In vivo; Mice; Rats; Smokeless tobacco; Toxicology

Indexed keywords

COTININE; NICOTINE;

ADRENAL GLAND; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEART WEIGHT; HISTOPATHOLOGY; HYPOPHYSIS; KIDNEY MASS; LIVER WEIGHT; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; OVARY; PROSTATE; RAT; SALIVARY GLAND; SEMINAL VESICLE; SEX DIFFERENCE; SMOKELESS TOBACCO; SPLEEN SIZE; TESTIS WEIGHT; THYMUS; THYROID GLAND; TOXICITY TESTING; TOXICOKINETICS; URINE LEVEL; UTERUS WEIGHT; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; COTININE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; FEMALE; MALE; MAXIMUM TOLERATED DOSE; MICE; MICE, INBRED STRAINS; NICOTINE; ORGAN SIZE; ORGAN SPECIFICITY; PLANT EXTRACTS; RATS; RATS, WISTAR; TOBACCO, SMOKELESS; TOXICITY TESTS, SUBCHRONIC;

MUS; NICOTIANA TABACUM; RATTUS; RODENTIA;

EID: 84857648564     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.05.013     Document Type: Article

References (5)

1. Krautter G.R., Potts R.J., Mould A.P. Comparative toxicity of nicotine and a tobacco pellet to Sprague-Dawley rats in a 90-day feeding study. American College of Toxicology annual meeting 2008.
2. LSRO Differentiating the health risks of categories of tobacco products 2008, Life Sciences Research Office Inc., Bethesda, MD, [accessed 3.24.10]. http://www.lsro.org/.
3. National Research Council Guide for the Care and Use of Laboratory Animals; 1996, Institute of Laboratory Animal Resources, Commission on Life Sciences, Washington, DC.
4. NCI Monograph 2: Smokeless tobacco or health: an international perspective 1992, [accessed 3.24.10]. http://cancercontrol.cancer.gov/TCRB/monographs/2/index.html.
5. Theophilus E.H., Hayes J.R., Potts R.J., Ayres P.H., Williams C.W., Garner C.D., Hejtmancik M.R., Fallacara D.M., Singer A.W. Toxicological evaluation of smokeless tobacco: 14- and 28-day rodent feeding studies. Toxicol Lett 198S 2009, S130.