Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 3, 2012, Pages 386-395

  Tarling, Elizabeth J ^a   Edwards, Peter A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ABC transporter; Cholesterol; Lipoprotein receptor; microRNA; Sterols

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G1; ABC TRANSPORTER G5; ABC TRANSPORTER G8; CELL NUCLEUS RECEPTOR; CELL SURFACE RECEPTOR; MICRORNA; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; HUMAN; INFLAMMATION; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; REVIEW; STEROL METABOLISM;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; MICRORNAS; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

MUS;

EID: 84857627380     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.07.011     Document Type: Review

References (129)

1. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365 (Pubitemid 29289663)
2. D.J. Parks, S.G. Blanchard, R.K. Bledsoe, G. Chandra, T.G. Consler, S.A. Kliewer, J.B. Stimmer, T.M. Willson, A.M. Zavacki, D.D. Moore, and J.M. Lehmann Bile acids: natural ligands for an orphan nuclear receptor Science 284 1999 1365 1368 (Pubitemid 29289664)
3. F.Y. Lee, H. Lee, M.L. Hubbert, P.A. Edwards, and Y. Zhang FXR, a multipurpose nuclear receptor Trends Biochem. Sci. 31 2006 572 580 (Pubitemid 44436939)
4. A.C. Calkin, and P. Tontonoz Liver x receptor signaling pathways and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 30 2010 1513 1518
5. J. Hu, Z. Zhang, W.J. Shen, and S. Azhar Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones Nutr. Metab. (Lond.) 7 2010 47 72
6. N.B. Javitt Oxysterols: novel biologic roles for the 21st century Steroids 73 2008 149 157
7. C. Yang, J.G. McDonald, A. Patel, Y. Zhang, M. Umetani, F. Xu, E.J. Westover, D.F. Covey, D.J. Mangelsdorf, J.C. Cohen, and H. Hobbs Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands J. Biol. Chem. 281 2006 27816 27826 (Pubitemid 44414494)
8. S.J. McTaggart Isoprenylated proteins Cell. Mol. Life Sci. 63 2006 255 267 (Pubitemid 43202309)
9. J.L. Goldstein, M.S. Brown, R.G.W. Anderson, D.W. Russell, and W.J. Schneider Receptor-mediated endocytosis: concepts emerging from the LDL receptor system Annu. Rev. Cell Biol. 1 1985 1 39
10. S.L. Stephen, K. Freestone, S. Dunn, M.W. Twigg, S. Homer-Vanniasinkam, J.H. Walker, S.B. Wheatcroft, and S. Ponnambalam Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease Int. J. Hypertens. 2010 2010
11. M. Abifadel, M. Varret, J.P. Rabes, D. Allard, K. Ouguerram, M. Devillers, C. Cruaud, S. Benjannet, L. Wickham, D. Erlich, A. Derre, L. Villeger, M. Farnier, I. Beucler, E. Bruckert, J. Chambaz, B. Chanu, J.M. Lecerf, G. Luc, P. Moulin, J. Weissenbach, A. Prat, M. Krempf, C. Junien, N.G. Seidah, and C. Boileau Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nat. Genet. 34 2003 154 156 (Pubitemid 36666925)
12. N. Zelcer, C. Hong, R. Boyadjian, and P. Tontonoz LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 325 2009 100 104
13. D. Zhang, R. Garuti, W.J. Tang, J.C. Cohen, and H.H. Hobbs Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor Proc. Natl. Acad. Sci. U. S. A. 105 2008 13045 13050
14. M. Hoekstra, T.J.C. Van Berkel, and M. Van Eck Scavanger receptor B1: a multi-purpose player in choletserol and steroid metabolism World J. Gastroenterol. 16 2010 5916 5924
15. A.M. Vaughan, and J.F. Oram ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL J. Lipid Res. 47 2006 2433 2443 (Pubitemid 44936105)
16. M.L. Wang, M. Motamed, R.E. Infante, L. Abi-Mosleh, H.J. Kwon, J.L. Goldstein, and M.S. Brown Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes Cell Metab. 12 2010 166 173
17. C. Cavelier, I. Lorenzi, L. Rohrer, and A. von Eckardstein Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1 Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1761 2006 655 666 (Pubitemid 44108746)
18. J. Wang, D. Zhang, Y. Lei, F. Xu, J.C. Cohen, H.H. Hobbs, and X.S. Xie Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8 Biochemistry 47 2008 5194 5204 (Pubitemid 351620756)
19. J.L. Betters, and L. Yu NPC1L1 and cholesterol transport FEBS Lett. 584 2010 2740 2747
20. W. Chen, G. Chen, D.L. Head, D.J. Mangelsdorf, and D.W. Russell Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice Cell Metab. 5 2007 73 79 (Pubitemid 44933109)
21. A. Radhakrishnan, Y. Ikeda, H.J. Kwon, M.S. Brown, and J.L. Goldstein Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig Proc. Natl. Acad. Sci. 104 2007 6511 6518 (Pubitemid 47175533)
22. A. Radhakrishnan, J.L. Goldstein, J.G. McDonald, and M.S. Brown Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance Cell Metab. 8 2008 512 521
23. A. Radhakrishnan, L.-P. Sun, H.J. Kwon, M.S. Brown, and J.L. Goldstein Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain Mol. Cell 15 2004 259 268 (Pubitemid 38950972)
24. M.S. Brown, and J.L. Goldstein Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J. Lipid Res. 50 2009 S15 S27
25. B.L. Song, N.B. Javitt, and R.A. DeBose-Boyd Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Cell Metab. 1 2005 179 189 (Pubitemid 43960599)
26. I. Gerin, L.A. Clerbaux, O. Haumont, N. Lanthier, A.K. Das, C.F. Burant, I.A. Leclercq, O.A. MacDougald, and G.T. Bommer Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation J. Biol. Chem. 285 2010 33652 33661
27. T. Horie, K. Ono, M. Horiguchi, H. Nishi, T. Nakamura, K. Nagao, M. Kinoshita, Y. Kuwabara, H. Marusawa, Y. Iwanaga, K. Hasegawa, M. Yokode, T. Kimura, and T. Kita MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo Proc. Natl. Acad. Sci. U. S. A. 107 2010 17321 17326
28. T.J. Marquart, R.M. Allen, D.S. Ory, and A. Baldan miR-33 links SREBP-2 induction to repression of sterol transporters Proc. Natl. Acad. Sci. U. S. A. 107 2010 12228 12232
29. S.H. Najafi-Shoushtari, F. Kristo, Y. Li, T. Shioda, D.E. Cohen, R.E. Gerszten, and A.M. Naar MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis Science 328 2010 1566 1569
30. K.J. Rayner, Y. Suarez, A. Davalos, S. Parathath, M.L. Fitzgerald, N. Tamehiro, E.A. Fisher, K.J. Moore, and C. Fernandez-Hernando MiR-33 contributes to the regulation of cholesterol homeostasis Science 328 2010 1570 1573
31. M.S. Brown, J. Ye, and J.L. Goldstein Medicine. HDL miR-ed down by SREBP introns Science 328 2010 1495 1496
32. V.I. Zannis, A. Chroni, and M. Krieger Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL J. Mol. Med. 84 2006 276 294
33. D.W. Bilheimer, Y.K. Ho, M.S. Brown, R.G. Anderson, and J.L. Goldstein Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia. J. Clin. Invest. 61 1978 678 696
34. M.S. Brown, P.T. Kovanen, J.L. Goldstein, R. Eeckels, K. Vandenberghe, H. van den Berghe, J.P. Fryns, and J.J. Cassiman Prenatal diagnosis of homozygous familial hypercholesterolemia. Expression of a genetic receptor disease in utero. Lancet 1 1978 526 529 (Pubitemid 8285638)
35. M. Bodzioch, E. Orso, J. Klucken, T. Langmann, A. Bottcher, W. Diederich, W. Drobnik, S. Barlage, C. Buchler, M. Porsch-Ozcurumez, W.E. Kaminski, H.W. Hahmann, K. Oette, G. Rothe, C. Aslanidis, K.J. Lackner, and G. Schmitz The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease Nat. Genet. 22 1999 347 351 (Pubitemid 29369524)
36. K.E. Berge, H. Tian, G.A. Graf, L. Yu, N.V. Grishin, J. Schultz, P. Kwiterovich, B. Shan, R. Barnes, and H. Hobbs Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adajacent ABC transporters Science 290 2000 1771 1775 (Pubitemid 32004809)
37. S.J. Steinberg, C.P. Ward, and A.H. Fensom Complementation studies in Niemann-Pick disease type C indicate the existence of a second group J. Med. Genet. 31 1994 317 320 (Pubitemid 24127532)
38. E.D. Carstea, J.A. Morris, K.G. Coleman, S.K. Loftus, D. Zhang, C. Cummings, J.Z. Gu, M.A. Rosenfeld, W.J. Pavan, D.B. Krizman, J. Nagle, M.H. Polymeropoulos, S.L. Sturley, Y.A. Ioannou, M.E. Higgins, M. Comly, A. Cooney, A. Brown, C.R. Kaneski, E.J. Blanchetter-Mackie, N.K. Dwyer, E.B. Neufeld, T.Y. Chang, L. Liscum, J.F.r. Strauss, K. Ohno, M. Zeigler, R. Carmi, J. Sokol, D. Markie, R.R. O'Neill, O.P. van Diggelen, M. Elleder, M.C. Patterson, R.O. Brady, M.T. Vanier, P.G. Pentchev, and D.A. Tagle Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis Science 277 1997 228 231 (Pubitemid 27446076)
39. K.E. Berge, L. Ose, and T.P. Leren Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy Arterioscler. Thromb. Vasc. Biol. 26 2006 1094 1100 (Pubitemid 43732117)
40. T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M. Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, C.J. Willer, C.T. Johansen, S.W. Fouchier, A. Issacs, G.M. Peloso, and M. Barbalic Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 2010 707 713
41. M. Ranalletta, K.K. Bierilo, Y. Chen, D. Milot, Q. Chen, E. Tung, C. Houde, N.H. Elowe, M. Garcia-Calvo, G. Porter, S. Eveland, B. Frantz-Wattley, M. Kavana, G. Addona, P. Sinclair, C. Sparrow, E.A. O'Neill, K.S. Koblan, A. Sitlani, B. Hubbard, and T.S. Fisher Biochemical characterization of cholesteryl ester transfer protein inhibitors J. Lipid Res. 51 2010 2739 2752
42. O. Weber, H. Bischoff, C. Schemck, and M.F. Bottcher Cholesteryl ester transfer protein and its inhibition Cell. Mol. Life Sci. 67 2010 3139 3149
43. M.L. Fitzgerald, Z. Mujawarm, and N. Tamehiro ABC transporters, atherosclerosis and inflammation Atherosclerosis 211 2010 361 370
44. G.S. Getz, and C.A. Reardon The ABC transporters and the thickening cholesterol plot Curr. Opin. Lipidol. 22 2011 72 73
45. I.D. Kerr, A.J. Haider, and I.C. Gelissen The ABCG family of membrane-associated transporters: you don't have to be big to be mighty Br. J. Pharmacol. 164 2011 1767 1779
46. P.T. Tarr, E.J. Tarling, D.D. Bojanic, P.A. Edwards, and A. Baldan Emerging new paradigms for ABCG transporters Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1791 2009 584 593
47. L. Yvan-Charvet, N. Wang, and A.R. Tall Role of HDL, ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses Arterioscler. Thromb. Vasc. Biol. 30 2010 139 143
48. P.M. Jones, and A.M. George The ABC transporter structure and mechanism: perspectives on new recent research Cell. Mol. Life Sci. 61 2004 682 699 (Pubitemid 38446412)
49. A. Baldan, D.D. Bojanic, and P.A. Edwards The ABCs of sterol transport J. Lipid Res. 50 2009 S80 S85
50. G. Moncalian, B. Lengsfeld, V. Bhaskara, K.P. Hopfner, A. Karcher, E. Alden, J.A. Tainer, and T.T. Paull The rad50 signature motif: essential to ATP binding and biological function J. Mol. Biol. 335 2004 937 951 (Pubitemid 38091602)
51. T.T. Paull, and J.H. Lee The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM Cell Cycle 4 2005 737 740 (Pubitemid 41353819)
52. A.A. Aleksandrov, L.A. Aleksandrov, and J.R. Riordan CFTR (ABCC7) is a hydrolyzable-ligand-gated channel Pflugers Arch. 453 2007 693 702 (Pubitemid 46192540)
53. R.J. Dawson, and K.P. Locher Structure of a bacterial multidrug ABC transporter Nature 443 2006 180 185 (Pubitemid 44387602)
54. C.A. McDevitt, C.A. Shintre, J.G. Grossmann, N.L. Pollock, S.M. Prince, R. Callaghan, and R.C. Ford Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography FEBS Lett. 582 2008 2950 2956
55. T.H. Morgan Sex limited inheritance in Drosophila Science 32 1910 120 122
56. D.T. Sullivan, L.A. Bell, D.R. Paton, and M.C. Sullivan Purine transport by malphigian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster Biochem. Genet. 17 1979 565 573 (Pubitemid 10241832)
57. D.T. Sullivan, L.A. Bell, D.R. Paton, and M.C. Sullivan Genetic and functional analysis of tryptophan transport in Malphigian tubules of Drosophila melanogaster Biochem. Genet. 18 1980 1109 1130 (Pubitemid 11156738)
58. M.A. Kennedy, G.C. Barrera, K. Nakamura, A. Baldan, P. Tarr, M.C. Fishbein, J. Frank, O.L. Francone, and P.A. Edwards ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation Cell Metab. 1 2005 121 131 (Pubitemid 43977167)
59. M.A. Kennedy, A. Venkateswaran, P.T. Tarr, I. Xenarios, J. Kudoh, N. Shimizu, and P.A. Edwards Characterization of the Human ABCG1 Gene. Liver X Receptor activates an internal promoter that producecs a novel transcript encoding an alternative form of the protein. J. Biol. Chem. 276 2001 39438 39447 (Pubitemid 37371322)
60. J. Klucken, C. Buchler, E. Orso, W.E. Kaminski, M. Porsch-Ozcurumez, G. Liebisch, M. Kapinsky, W. Diederich, W. Drobnik, M. Dean, R. Allikmets, and G. Schmitz ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport Proc. Natl. Acad. Sci. U. S. A. 97 2000 817 822 (Pubitemid 30070393)
61. B.A. Laffitte, J.J. Repa, S.B. Joseph, D.C. Wilpitz, H.R. Kast, D.J. Mangelsdorf, and P. Tontonoz LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes Proc. Natl. Acad. Sci. 98 2001 507 512 (Pubitemid 32105072)
62. S.L. Sabol, H.B. Brewer Jr., and S. Santamarina-Fojo The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver J. Lipid Res. 46 2005 2151 2167 (Pubitemid 41377467)
63. T. Jakobsson, N. Venteclef, G. Toresson, A.E. Damdimopoulous, A. Ehrlund, X. Lou, S. Sanyal, K.R. Steffensen, J.A. Gustafsson, and E. Treuter GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus Mol. Cell 34 2009 510 518
64. T. Engel, G. Bode, A. Lueken, M. Knop, F. Kannenberg, J.-R. Nofer, G. Assmann, and U. Seedorf Expression and functional characterization of ABCG1 splice variant ABCG1(666) FEBS Lett. 580 2006 4551 4559 (Pubitemid 44118259)
65. K. Nakamura, M.A. Kennedy, A. Baldan, D.D. Bojanic, K. Lyons, and P.A. Edwards Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein J. Biol. Chem. 279 2004 45980 45989 (Pubitemid 39491591)
66. M.H. Nagelin, S. Srinivasan, J. Lee, J.L. Nadler, and C.C. Hedrick 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1 Arterioscler. Thromb. Vasc. Biol. 28 2008 1811 1819
67. M.H. Nagelin, S. Srinivasan, J.L. Nadler, and C.C. Hedrick Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways J. Biol. Chem. 284 2009 31303 31314
68. D. Li, D. Wang, Y. Wang, W. Ling, X. Feng, and M. Xia Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice J. Biol. Chem. 285 2010 33499 33509
69. D. Li, Y. Zhang, J. Ma, W. Ling, and M. Xia Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction Arterioscler. Thromb. Vasc. Biol. 30 2010 1354 1362
70. A. Baldan, P. Tarr, C.S. Vales, J. Frank, T.K. Shimotake, S. Hawgood, and P.A. Edwards Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis J. Biol. Chem. 281 2006 29401 29410 (Pubitemid 44507083)
71. P.T. Tarr, and P.A. Edwards ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 J. Lipid Res. 49 2008 169 182
72. X. Wang, H.L. Collins, M. Ranalletta, I. Fuki, J.T. Billheimer, G.H. Rothblat, A.R. Tall, and D.J. Rader Macrophage ABCA1 and ABCG1, but not SR-B1, promote macrophage reverse cholesterol transport in vivo J. Clin. Invest. 117 2007 2216 2224 (Pubitemid 47219566)
73. I.C. Gelissen, M. Harris, K.-A. Rye, C. Quinn, A.J. Brown, M. Kockx, S. Cartland, M. Packianathan, L. Kritharides, and W. Jessup ABCA1 and ABCG1 synergize to mediate cholesterol export to ApoA-I Arterioscler. Thromb. Vasc. Biol. 26 2006 534 540
74. A. Kobayashi, Y. Takanezawa, T. Hirata, Y. Shimizu, K. Misasa, N. Kioka, H. Arai, K. Ueda, and M. Matsuo Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 J. Lipid Res. 47 2006 1791 1802 (Pubitemid 44222830)
75. S. Sankaranarayanan, J.F. Oram, B.F. Asztalos, A.M. Vaughan, S. Lund-Katz, M.P. Adorni, M.C. Phillips, and G.H. Rothblat Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux J. Lipid Res. 50 2009 275 284
76. A.M. Vaughan, and J.F. Oram ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins J. Biol. Chem. 280 2005 30150 30157 (Pubitemid 41216193)
77. N. Wang, D. Lan, W. Chen, F. Matsuura, and A.R. Tall ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins Proc. Natl. Acad. Sci. U. S. A. 101 2004 9774 9779 (Pubitemid 38869312)
78. B. Burgess, K. Naus, J. Chan, V. Hirsch-Reinshagen, G. Tansley, L. Matzke, B. Chan, A. Wilkinson, J. Fan, J. Donkin, D. Balik, T. Tanaka, G. Ou, R. Dyer, S. Innis, B. McManus, D. Lutjohann, and C. Wellington Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice Arterioscler. Thromb. Vasc. Biol. 28 2008 1731 1737
79. G.H. Rothblat, M. Bamberger, and M.C. Phillips Reverse cholesterol transport Methods Enzymol. 129 2003 628 644
80. N. Wang, M. Ranalletta, F. Matsuura, F. Peng, and A.R. Tall LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL Arterioscler. Thromb. Vasc. Biol. 26 2006 1310 1316 (Pubitemid 44305375)
81. Q. Xie, T. Engel, M. Schnoor, J. Niehaus, O. Hofnagel, I. Buers, P. Cullen, U. Seedorf, G. Assmann, and S. Lorkowski Cell surface localization of ABCG1 does not require LXR activation Arterioscler. Thromb. Vasc. Biol. 26 2006 e143 e144
82. J.M. Sturek, J.D. Castle, A.P. Trace, L.C. Page, A.M. Castle, C. Evans-Molina, J.S. Parks, R.G. Mirmira, and C.C. Hedrick An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells J. Clin. Invest. 120 2010 2575 2589
83. M. Cuchel, S. Lund-Katz, M. de la Llera-Moya, J.S. Millar, D. Chang, I. Fuki, G.H. Rothblat, M.C. Phillips, and D.J. Rader Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages Arterioscler. Thromb. Vasc. Biol. 30 2010 526 532
84. A. Hoang, B.G. Drew, H. Low, A.T. Remaley, P. Nestel, B.A. Kingwell, D. Sviridov, Mechanism of cholesterol efflux in humans after infusion of reconstituted high-density lipoprotein, Eur. Heart J. (in press). [Electronic publication ahead of print].
85. A.C. Edmondson, P.S. Braund, I.M. Stylianou, A.V. Khera, C.P. Nelson, M.L. Wolfe, S.L. Derohannessian, B.J. Keating, L. Qu, J. He, M.D. Tobin, M. Tomaszewski, J. Baumert, N. Klopp, A. Doring, B. Thorand, M. Li, M.P. Reilly, W. Koenig, N.J. Samani, and D.J. Rader Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol Circ. Cardiovasc. Genet. 4 2011 145 155
86. C. Vedhachalam, P.T. Duong, M. Nickel, D. Nguyen, P. Dhanasekaran, H. Saito, G.H. Rothblat, S. Lund-Katz, and M.C. Phillips Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-1 and formation of high density lipoprotein particles J. Biol. Chem. 282 2007 25123 25130 (Pubitemid 47347535)
87. W.-T. Chao, S.-H. Tsai, Y.-C. Lin, W.-W. Lin, and V.C. Yang Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation Biochem. Biophys. Res. Commun. 332 2005 743 749 (Pubitemid 40745176)
88. L.E. Smith, and S. Davidson The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-1 in lipid binding and ABCA1-mediated cholesterol efflux Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1801 2010 64 69
89. J. Wang, F. Sun, D.W. Zhang, Y. Ma, F. Xu, J.D. Belani, J.C. Cohen, H. Hobbs, and X.S. Xie Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution J. Biol. Chem. 281 2006 27894 27904 (Pubitemid 44414501)
90. L. Yu, S. Gupta, F. Xu, A.D.B. Liverman, A. Moschetta, D.J. Mangelsdorf, J.J. Repa, H. Hobbs, and J.C. Cohen Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion J. Biol. Chem. 280 2005 8742 8747 (Pubitemid 40409561)
91. C. Yang, L. Yu, W. Li, F. Xu, J.C. Cohen, and H. Hobbs Disruption of cholestero homeostasis by plant sterols J. Clin. Invest. 114 2004 813 822 (Pubitemid 39578740)
92. D.D. Bojanic, P.T. Tarr, G.D. Gale, D.J. Smith, D. Bok, B. Chen, S. Nusinowitz, A. Lovgren-Sandblom, I. Bjorkhem, and P.A. Edwards Differential expression and function of ABCG1 and ABCG4 during development and ageing J. Lipid Res. 51 2009 169 181
93. T. Engel, F. Kannenberg, M. Fobker, J.-R. Nofer, G. Bode, A. Lueken, G. Assmann, and U. Seedorf Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7[beta]-hydroxycholesterol FEBS Lett. 581 2007 1673 1680 (Pubitemid 46528932)
94. E.J. Tarling, D.D. Bojanic, R.K. Tangirala, X. Wang, A. Lovgren-Sandblom, A.J. Lusis, I. Bjorkhem, and P.A. Edwards Impaired development of atherosclerosis in Abcg1-/-Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/-Apoe-/- tissues and induce apoptosis Arterioscler. Thromb. Vasc. Biol. 30 2010 1174 1180
95. N. Terasaka, N. Wang, L. Yvan-Charvet, and A.R. Tall High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1 Proc. Natl. Acad. Sci. U. S. A. 104 2007 15093 15098 (Pubitemid 47619598)
96. N. Wang, L. Yvan-Charvet, D. Lutjohann, M. Mulder, T. Vanmierlo, T.-W. Kim, and A.R. Tall ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain FASEB J. 22 2008 1073 1082 (Pubitemid 351519962)
97. J. Buchmann, C. Meyer, S. Neschen, R. Augustin, K. Schmolz, R. Kluge, H. Al-Hasani, H. Jurgens, K. Eulenberg, R. Wehr, C. Dohrmann, H.G. Joost, and A. Schurmann Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduced adipose cell size and protects against diet-induced obesity Endocrinology 148 2007 1561 1573 (Pubitemid 46457102)
98. R. Out, M. Hoekstra, R.B. Hildebrand, J.K. Kruit, I. Meurs, Z. Li, F. Kuipers, T.J.C. Van Berkel, and M. Van Eck Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice Arterioscler. Thromb. Vasc. Biol. 26 2006 2295 2300 (Pubitemid 44465725)
99. A. Baldan, A.V. Gomes, P. Ping, and P.A. Edwards Loss of ABCG1 results in chronic pulmonary inflammation J. Immunol. 180 2008 3560 3568
100. A.J. Wojcik, M.D. Skaflen, S. Srinivasan, and C.C. Hedrick A critical role for ABCG1 in macrophage inflammation and lung homeostasis J. Immunol. 180 2008 4273 4282
101. C.L. Wellington, E.K. Walker, A. Suarez, A. Kwok, N. Bissada, R. Singaraja, Y.Z. Yang, L.H. Zhang, E. James, J.E. Wilson, O.L. Francone, B. McManus, and M.R. Hayden ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation Lab. Invest. 82 2002 273 283 (Pubitemid 34242521)
102. L. Yvan-Charvet, C. Welch, T.A. Pagler, M. Ranalletta, M. Lamkanfi, S. Han, M. Ishibashi, R. Li, N. Wang, and A.R. Tall Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions Circulation 118 2008 1837 1847
103. V.M. Rimkunas, M.J. Graham, R.M. Crooke, and L. Liscum TNF-alpha plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease J. Lipid Res. 50 2009 327 333
104. B. Liu, S.D. Turley, D.K. Burns, A.M. Miller, J.J. Repa, and J.M. Dietschy Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse Proc. Natl. Acad. Sci. U. S. A. 106 2009 2377 2382
105. U. Klein, G. Gimpl, and F. Fahrenholz Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor Biochemistry 34 1995 13784 13793
106. E.P.C. Kilsdonk, P.G. Yancey, G.W. Stoudt, F.W. Bangerter, W.J. Johnson, M.C. Phillips, and G.H. Rothblat Cellular cholesterol efflux mediated by cyclodextrins J. Biol. Chem. 270 1995 17250 17256
107. B.J. O'Connell, M. Denis, and J. Genest Cellular physiology of cholesterol efflux in vascular endothelial cells Circulation 110 2004 2881 2888 (Pubitemid 39473613)
108. A.M. Whetzel, J.M. Sturek, M.H. Nagelin, D.T. Bolick, A.K. Gebre, J.S. Parks, A.C. Bruce, M.D. Skaflen, and C.C. Hedrick ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions Arterioscler. Thromb. Vasc. Biol. 30 2010 809 817
109. N. Terasaka, M. Westerterp, J. Koetsveld, C. Fernandez-Hernando, L. Yvan-Charvet, N. Wang, W.C. Sessa, and A.R. Tall ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase Arterioscler. Thromb. Vasc. Biol. 30 2010 2219 2225
110. A.J. Lusis Atherosclerosis Nature 407 2000 233 241
111. A. Baldan, L. Pei, R. Lee, P. Tarr, R.K. Tangirala, M.M. Weinstein, J. Frank, A.C. Li, P. Tontonoz, and P.A. Edwards Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow Arterioscler. Thromb. Vasc. Biol. 26 2006 2301 2307 (Pubitemid 44465726)
112. M. Ranalletta, N. Wang, S. Han, L. Yvan-Charvet, C. Welch, and A.R. Tall Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow Arterioscler. Thromb. Vasc. Biol. 26 2006 2308 2315 (Pubitemid 44465727)
113. F. Basso, M.J. Amar, E.M. Wagner, B. Vaisman, B. Paigen, S. Santamarina-Fojo, and A.T. Remaley Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet Biochem. Biophys. Res. Commun. 351 2006 398 404 (Pubitemid 44679753)
114. R. Out, M. Hoekstra, K. Habets, I. Meurs, V. de Waard, R.B. Hildebrand, Y. Wang, G. Chimini, J. Kuiper, T.J.C. Van Berkel, and M. Van Eck Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels Arterioscler. Thromb. Vasc. Biol. 28 2008 258 264 (Pubitemid 351161197)
115. R. Out, W. Jessup, W. Le Goff, M. Hoekstra, I.C. Gelissen, Y. Zhao, L. Kritharides, G. Chimini, J. Kuiper, M.J. Chapman, T. Huby, T.J.C. Van Berkel, and M. Van Eck Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1 Circ. Res. 102 2008 113 120
116. L. Yvan-Charvet, M. Ranalletta, N. Wang, S. Han, N. Terasaka, R. Li, C. Welch, and A.R. Tall Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice J. Clin. Invest. 117 2007 3900 3908 (Pubitemid 350224099)
117. T.A. Pagler, M.L. Wang, M. Mondal, A.J. Murphy, M. Westerterp, K.J. Moore, F.R. Maxfield, and A.R. Tall Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling Circ. Res. 108 2011 194 200
118. B. Lammers, R. Out, R.B. Hildebrand, C.M. Quinn, D. Williamson, M. Hoekstra, I. Meurs, T.J.C. Van Berkel, W. Jessup, and M. Van Eck Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development Atherosclerosis 205 2009 420 426
119. L.R. Brunham, J.K. Kruit, C.B. Verchere, and M.R. Hayden Cholesterol in islet dysfunction and type 2 diabetes J. Clin. Invest. 118 2008 403 408 (Pubitemid 351206525)
120. B.S. Coller Leukocytosis and ischemic vascular disease morbidity and mortality. Is it time to intervene? Arterioscler. Thromb. Vasc. Biol. 25 2005 658 670 (Pubitemid 40463851)
121. S.J. Bensinger, M.N. Bradley, S.B. Joseph, N. Zelcer, E.M. Janssen, M.A. Hausner, R. Shih, J.S. Parks, P.A. Edwards, B.D. Jamieson, and P. Tontonoz LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 2008 97 111 (Pubitemid 351905740)
122. A.J. Armstrong, A.K. Gebre, J.S. Parks, and C.C. Hedrick ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation J. Immunol. 184 2010 173 183
123. L. Yvan-Charvet, T.A. Pagler, E.L. Gautier, S. Avagyan, R.L. Siry, S. Han, C. Welch, N. Wang, G.J. Randolph, H.W. Snoeck, and A.R. Tall ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation Science 328 2010 1689 1693
124. J.F. Oram, J.J. Albers, M.C. Cheung, and E.L. Bierman The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity. J. Biol. Chem. 256 1981 8348 8356 (Pubitemid 12254785)
125. G.A. Francis, R.H. Knopp, and J.F. Oram Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-1 in Tangier Disease J. Clin. Invest. 96 1995 78 87
126. R.M. Lawn, D.P. Wade, M.R. Garvin, X. Wang, K. Schwartz, J.G. Porter, J.J. Seilhamer, A.M. Vaughan, and J.F. Oram The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway J. Clin. Invest. 104 1999 R25 R31
127. G. Lin, and J.F. Oram Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol Atherosclerosis 149 2000 359 370 (Pubitemid 30145546)
128. J.F. Oram HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol Arterioscler. Thromb. Vasc. Biol. 23 2003 720 727 (Pubitemid 36566158)
129. C. Tang, and J.F. Oram The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1791 2009 563 572