Unmet challenges in the use of novel agents in locally advanced non-small-cell lung cancer

Journal of Clinical Oncology

Volumn 30, Issue 6, 2012, Pages 582-584

  Decker, Roy H ^a   Lynch, Thomas J ^a  

^a YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 3; GEMCITABINE; IRINOTECAN; PACLITAXEL; PLATINUM; RTOG 0617; THALIDOMIDE; TRASTUZUMAB; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTIANGIOGENIC THERAPY; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CONSOLIDATION CHEMOTHERAPY; DRUG TREATMENT FAILURE; EDITORIAL; HUMAN; IMMUNOMODULATION; LUNG NON SMALL CELL CANCER; MULTIPLE MYELOMA; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; THROMBOEMBOLISM;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; THALIDOMIDE;

EID: 84857608348     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.40.1471     Document Type: Editorial

References (15)

1. Sequist LV, Heist RS, Shaw AT, et al: Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 22:2616-2624, 2011
2. Hoang T, Dahlberg SE, Schiller JH, et al: Randomized phase III study of thoracic radiation in combination with paclitaxel and carboplatin with or without thalidomide in patients with stage III non-small-cell lung cancer: The ECOG 3598 Study. J Clin Oncol 30:616-622, 2012
3. Jain RK: Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307:58-62, 2005
4. Sandler A, Gray R, Perry MC, et al: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542-2550, 2006 (Pubitemid 44917502)
5. Spigel DR, Hainsworth JD, Yardley DA, et al: Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab. J Clin Oncol 28:43-48, 2010
6. Merchant JJ, Kim K, Mehta MP, et al: Pilot and safety trial of carboplatin, paclitaxel, and thalidomide in advanced non small-cell lung cancer. Clin Lung Cancer 2:48-52; discussion 53-54, 2000
7. Jazieh AR, Komrokji R, Gupta A, et al: Phase II trial of thalidomide, irinotecan and gemcitabine in chemonaive patients with advanced non-small cell lung cancer. Cancer Invest 27:932-936, 2009
8. Dudek AZ, Lesniewski-Kmak K, Larson T, et al: Phase II trial of neoadjuvant therapy with carboplatin, gemcitabine plus thalidomide for stages IIB and III non-small cell lung cancer. J Thorac Oncol 4:969-975, 2009
9. Miller AA, Case D, Atkins JN, et al: Phase II study of carboplatin, irinotecan, and thalidomide in patients with advanced non-small cell lung cancer. J Thorac Oncol 1:832-836, 2006 (Pubitemid 47181389)
10. Lee SM, Rudd R, Woll PJ, et al: Randomized double-blind placebo-controlled trial of thalidomide in combination with gemcitabine and carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 27:5248-5254, 2009
11. Paravar T, Lee DJ: Thalidomide: Mechanisms of action. Int Rev Immunol 27:111-135, 2008 (Pubitemid 351589822)
12. Curran WJ Jr, Paulus R, Langer CJ, et al: Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: Randomized phase III trial RTOG 9410. J Natl Cancer Inst 103:1452-1460, 2011
13. Perez CA, Stanley K, Rubin P, et al: A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung: Preliminary report by the Radiation Therapy Oncology Group. Cancer 45:2744-2753, 1980 (Pubitemid 10063330)
14. Bradley J, Graham MV, Winter K, et al: Toxicity and outcome results of RTOG 9311: A phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 61:318-328, 2005 (Pubitemid 40164423)
15. Kong FM, Ten Haken RK, Schipper MJ, et al: High-dose radiation improved local tumor control and overall survival in patients with inoperable/ unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 63:324-333, 2005 (Pubitemid 41317147)