Systemic antifungal therapy in patients without documented invasive fungal infection: A peek into the world of empirical antifungal therapy

Critical Care Medicine

Volumn 40, Issue 3, 2012, Pages 997-998

  Ostrosky Zeichner, Luis ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

empirical antifungal therapy; ICU; invasive fungal infections

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; CASPOFUNGIN; FLUCONAZOLE; PLACEBO; VORICONAZOLE;

ANTIFUNGAL RESISTANCE; CANDIDEMIA; CANDIDIASIS; CRYPTOCOCCOSIS; EDITORIAL; FUNGAL COLONIZATION; HUMAN; INFECTION PREVENTION; INFECTION RISK; INTENSIVE CARE UNIT; MORTALITY; PREVALENCE; PRIORITY JOURNAL; SYSTEMIC MYCOSIS;

ANTIFUNGAL AGENTS; FEMALE; HUMANS; MALE;

EID: 84857551253     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31823e9514     Document Type: Editorial

References (9)

1. Wisplinghoff H, Bischoff T, Tallent SM, et al: Nosocomial bloodstream infections in US hospitals: Analysis of 24, 179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004;39:309-317
2. Meersseman W, Van Wijngaerden E: Invasive aspergillosis in the ICU: An emerging disease. Intensive Care Med 2007;33:1679-1681
3. Park BJ, Wannemuehler KA, Marston BJ, et al: Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009;23:525-530
4. Alexander BD: Diagnosis of fungal infection: New technologies for the mycology laboratory. Transpl Infect Dis 2002;4(Suppl 3):32-37
5. Garey KW, Turpin RS, Bearden DT, et al: Economic analysis of inadequate fluconazole therapy in non-neutropenic patients with candidaemia: A multi-institutional study. Int J Antimicrob Agents 2007;29:557-562
6. Garey KW, Rege M, Pai MP, et al: Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional study. Clin Infect Dis 2006;43:25-31
7. Chamilos G, Lewis RE, Kontoyiannis DP: Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis. Clin Infect Dis 2008;47:503-509
8. Schuster MG, Edwards JE Jr, Sobel JD, et al: Empirical fluconazole versus placebo for intensive care unit patients: A randomized trial. Ann Intern Med 2008;149:83-90
9. Azoulay E, Dupont H, Tabah A, et al: Systemic antifungal therapy in critically ill patients without invasive fungal infection. Crit Care Med 2012;40:813-822