메뉴 건너뛰기




Volumn 8, Issue 1, 2012, Pages 31-42

Emerging and second line therapies for the management of metastatic castration-resistant prostate cancer: The Australian perspective

Author keywords

Abiraterone acetate; Cabazitaxel; Innovative therapy; Prostate cancer; Sipuleucel T

Indexed keywords

4 [3 [4 CYANO 3 (TRIFLUOROMETHYL)PHENYL] 5,5 DIMETHYL 4 OXO 2 THIOXO 1 IMIDAZOLIDINYL] 2 FLUORO N METHYLBENZAMIDE; ABIRATERONE ACETATE; BICALUTAMIDE; BOSUTINIB; CABAZITAXEL; CABOZANTINIB; DASATINIB; DENOSUMAB; DOCETAXEL; ESTRAMUSTINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; HYDROCORTISONE; IPILIMUMAB; LEUPRORELIN; MITOXANTRONE; ORTERONEL; PLACEBO; PREDNISONE; PROSTATE SPECIFIC ANTIGEN; RADIOISOTOPE; RADIUM 223; SAMARIUM 153; SARACATINIB; SATRAPLATIN; SIPULEUCEL T; STRONTIUM 89; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIBOTENTAN; ZOLEDRONIC ACID;

EID: 84857527257     PISSN: 17437555     EISSN: 17437563     Source Type: Journal    
DOI: 10.1111/j.1743-7563.2011.01506.x     Document Type: Review
Times cited : (4)

References (69)
  • 1
    • 80155191727 scopus 로고    scopus 로고
    • Australian Institute of Health and Welfare and Australian Association of Cancer Registries. AIHW, Canberra Report No.: Cancer Series Number 60.
    • Australian Institute of Health and Welfare and Australian Association of Cancer Registries. Cancer in Australia: An Overview 2010. AIHW, Canberra 2011. Report No.: Cancer Series Number 60.
    • (2011) Cancer in Australia: An Overview 2010
  • 2
    • 33846689253 scopus 로고    scopus 로고
    • Prostate cancer: a practical approach to current management of recurrent disease
    • Walczak JR, Carducci MA. Prostate cancer: a practical approach to current management of recurrent disease. Mayo Clin Proc 2007; 82: 243-9.
    • (2007) Mayo Clin Proc , vol.82 , pp. 243-249
    • Walczak, J.R.1    Carducci, M.A.2
  • 3
    • 67650376190 scopus 로고    scopus 로고
    • Emerging therapies in castrate-resistant prostate cancer
    • Lassi K, Dawson NA. Emerging therapies in castrate-resistant prostate cancer. Curr Opin Oncol 2009; 21: 260-5.
    • (2009) Curr Opin Oncol , vol.21 , pp. 260-265
    • Lassi, K.1    Dawson, N.A.2
  • 4
    • 0021796372 scopus 로고
    • A reevaluation of nonhormonal cytotoxic chemotherapy in the treatment of prostatic carcinoma
    • Eisenberger MA, Simon R, O'Dwyer PJ, Wittes RE, Friedman MA. A reevaluation of nonhormonal cytotoxic chemotherapy in the treatment of prostatic carcinoma. J Clin Oncol 1985; 3: 827-41.
    • (1985) J Clin Oncol , vol.3 , pp. 827-841
    • Eisenberger, M.A.1    Simon, R.2    O'Dwyer, P.J.3    Wittes, R.E.4    Friedman, M.A.5
  • 5
    • 0027532535 scopus 로고
    • Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer
    • Yagoda A, Petrylak D. Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer. Cancer 1993; 71 (Suppl):1098-109.
    • (1993) Cancer , vol.71 , Issue.SUPPL. , pp. 1098-1109
    • Yagoda, A.1    Petrylak, D.2
  • 6
    • 8944220720 scopus 로고    scopus 로고
    • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points
    • Tannock IF, Osoba D, Stockler MR etal. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J Clin Oncol 1996; 14: 1756-64.
    • (1996) J Clin Oncol , vol.14 , pp. 1756-1764
    • Tannock, I.F.1    Osoba, D.2    Stockler, M.R.3
  • 7
    • 0032784113 scopus 로고    scopus 로고
    • Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study
    • Kantoff PW, Halabi S, Conaway M etal. Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study. J Clin Oncol 1999; 17: 2506-13.
    • (1999) J Clin Oncol , vol.17 , pp. 2506-2513
    • Kantoff, P.W.1    Halabi, S.2    Conaway, M.3
  • 8
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH etal. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004; 351: 1513-20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 9
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR etal. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351: 1502-12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    de Wit, R.2    Berry, W.R.3
  • 10
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group
    • Scher HI, Halabi S, Tannock I etal. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol 2008; 26: 1148-59.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3
  • 11
    • 77952635453 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: current and emerging treatment strategies
    • Di Lorenzo G, Buonerba C, Autorino R, De Placido S, Sternberg CN. Castration-resistant prostate cancer: current and emerging treatment strategies. Drugs 2010; 70: 983-1000.
    • (2010) Drugs , vol.70 , pp. 983-1000
    • Di Lorenzo, G.1    Buonerba, C.2    Autorino, R.3    De Placido, S.4    Sternberg, C.N.5
  • 12
    • 79952638007 scopus 로고    scopus 로고
    • Critical appraisal of cabazitaxel in the management of advanced prostate cancer
    • Pal SK, Twardowski P, Sartor O. Critical appraisal of cabazitaxel in the management of advanced prostate cancer. Clin Interv Aging 2010; 5: 395-402.
    • (2010) Clin Interv Aging , vol.5 , pp. 395-402
    • Pal, S.K.1    Twardowski, P.2    Sartor, O.3
  • 13
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND etal. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363: 411-22.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 14
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
    • de Bono JS, Oudard S, Ozguroglu M etal. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 2010; 376: 1147-54.
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • de Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 15
    • 84857562474 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. Practice guidelines in oncology: prostate cancer. Report No.: Version 1.
    • National Comprehensive Cancer Network. Practice guidelines in oncology: prostate cancer. 2011. Report No.: Version 1.
    • (2011)
  • 16
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • Small EJ, Schellhammer PF, Higano CS etal. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006; 24: 3089-94.
    • (2006) J Clin Oncol , vol.24 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3
  • 17
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • Higano CS, Schellhammer PF, Small EJ etal. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 2009; 115: 3670-9.
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 18
    • 79955725583 scopus 로고    scopus 로고
    • Listening to Provenge - what a costly cancer treatment says about future Medicare policy
    • Chambers JD, Neumann PJ. Listening to Provenge - what a costly cancer treatment says about future Medicare policy. N Engl J Med 2011; 364: 1687-9.
    • (2011) N Engl J Med , vol.364 , pp. 1687-1689
    • Chambers, J.D.1    Neumann, P.J.2
  • 19
    • 84857562475 scopus 로고    scopus 로고
    • Rechallenge with docetaxel as second-line chemotherapy in patients with metastatic hormone refractory prostate cancer (HRPC) after previous docetaxel: a population based analysis. Presented at ASCO Genitourinary Cancers Symposium; February 14-16, San Francisco, CA. Abstract 196.
    • Jankovic B, Beardsley E, Chi K. Rechallenge with docetaxel as second-line chemotherapy in patients with metastatic hormone refractory prostate cancer (HRPC) after previous docetaxel: a population based analysis. Presented at ASCO Genitourinary Cancers Symposium; February 14-16, San Francisco, CA. Abstract 196. 2008.
    • (2008)
    • Jankovic, B.1    Beardsley, E.2    Chi, K.3
  • 20
    • 84857557313 scopus 로고    scopus 로고
    • Docetaxel retreatment as second- and third-line chemotherapy in metastatic hormone refractory prostate cancer patients pretreated with docetaxel: an updated analysis. Presented at ASCO Genitourinary Cancers Symposium; February 26-29; Orlando, FL. Abstract 185.
    • Ansari MS, Choo CM, Hussain M. Docetaxel retreatment as second- and third-line chemotherapy in metastatic hormone refractory prostate cancer patients pretreated with docetaxel: an updated analysis. Presented at ASCO Genitourinary Cancers Symposium; February 26-29; Orlando, FL. Abstract 185. 2009.
    • (2009)
    • Ansari, M.S.1    Choo, C.M.2    Hussain, M.3
  • 21
    • 77953289240 scopus 로고    scopus 로고
    • The interval from the last cycle of docetaxel-based chemotherapy to progression is associated with the efficacy of subsequent docetaxel in patients with prostate cancer
    • Loriot Y, Massard C, Gross-Goupil M etal. The interval from the last cycle of docetaxel-based chemotherapy to progression is associated with the efficacy of subsequent docetaxel in patients with prostate cancer. Eur J Cancer 2010; 46: 1770-2.
    • (2010) Eur J Cancer , vol.46 , pp. 1770-1772
    • Loriot, Y.1    Massard, C.2    Gross-Goupil, M.3
  • 22
    • 77956556274 scopus 로고    scopus 로고
    • Docetaxel reintroduction in patients with metastatic castration-resistant docetaxel-sensitive prostate cancer: a retrospective multicentre study
    • Eymard JC, Oudard S, Gravis G etal. Docetaxel reintroduction in patients with metastatic castration-resistant docetaxel-sensitive prostate cancer: a retrospective multicentre study. BJU Int 2010; 106: 974-8.
    • (2010) BJU Int , vol.106 , pp. 974-978
    • Eymard, J.C.1    Oudard, S.2    Gravis, G.3
  • 23
    • 78650445988 scopus 로고    scopus 로고
    • Phase II study of docetaxel re-treatment in docetaxel-pretreated castration-resistant prostate cancer
    • Di Lorenzo G, Buonerba C, Faiella A etal. Phase II study of docetaxel re-treatment in docetaxel-pretreated castration-resistant prostate cancer. BJU Int 2011; 107: 234-9.
    • (2011) BJU Int , vol.107 , pp. 234-239
    • Di Lorenzo, G.1    Buonerba, C.2    Faiella, A.3
  • 24
    • 84869220434 scopus 로고    scopus 로고
    • Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review
    • 21 February [Epub ahead of print].
    • Colloca G, Venturino A, Checcaglini F. Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review. Med Oncol 2011; 21 February [Epub ahead of print].
    • (2011) Med Oncol
    • Colloca, G.1    Venturino, A.2    Checcaglini, F.3
  • 25
    • 73949098659 scopus 로고    scopus 로고
    • Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial
    • Sternberg CN, Petrylak DP, Sartor O etal. Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial. J Clin Oncol 2009; 27: 5431-8.
    • (2009) J Clin Oncol , vol.27 , pp. 5431-5438
    • Sternberg, C.N.1    Petrylak, D.P.2    Sartor, O.3
  • 27
    • 0034857136 scopus 로고    scopus 로고
    • Preclinical evaluation of new taxoids
    • Bissery MC. Preclinical evaluation of new taxoids. Curr Pharm Des 2001; 7: 1251-7.
    • (2001) Curr Pharm Des , vol.7 , pp. 1251-1257
    • Bissery, M.C.1
  • 28
    • 84857603033 scopus 로고    scopus 로고
    • A subgroup analysis of the TROPIC trial exploring reason for discontinuation of prior docetaxel and survival outcome of cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC)
    • De Bono JS, Oudard S, Ozguroglu M etal. A subgroup analysis of the TROPIC trial exploring reason for discontinuation of prior docetaxel and survival outcome of cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 2011; 29 (Suppl): Abstract 4526.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 29
    • 59449102526 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of XRP6258 (RPR 116258A), a novel taxane, administered as a 1-hour infusion every 3weeks in patients with advanced solid tumors
    • Mita AC, Denis LJ, Rowinsky EK etal. Phase I and pharmacokinetic study of XRP6258 (RPR 116258A), a novel taxane, administered as a 1-hour infusion every 3weeks in patients with advanced solid tumors. Clin Cancer Res 2009; 15: 723-30.
    • (2009) Clin Cancer Res , vol.15 , pp. 723-730
    • Mita, A.C.1    Denis, L.J.2    Rowinsky, E.K.3
  • 30
    • 50849088935 scopus 로고    scopus 로고
    • A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3weeks in taxane-resistant metastatic breast cancer patients
    • Pivot X, Koralewski P, Hidalgo JL etal. A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3weeks in taxane-resistant metastatic breast cancer patients. Ann Oncol 2008; 19: 1547-52.
    • (2008) Ann Oncol , vol.19 , pp. 1547-1552
    • Pivot, X.1    Koralewski, P.2    Hidalgo, J.L.3
  • 31
    • 85075544887 scopus 로고    scopus 로고
    • 2 with prednisone for the treatment of metastatic castration resistant prostate cancer (PROSELICA). Study NCT01308580. [cited 16 Aug 2011]. Available from:
    • 2 with prednisone for the treatment of metastatic castration resistant prostate cancer (PROSELICA). Study NCT01308580. 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 32
    • 84857557317 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Cabazitaxel versus docetaxel both with prednisone in patients with metastatic castration resistant prostate cancer (FIRSTANA). Study NCT01308567. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Cabazitaxel versus docetaxel both with prednisone in patients with metastatic castration resistant prostate cancer (FIRSTANA). Study NCT01308567. 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 33
    • 79851510026 scopus 로고    scopus 로고
    • Novel therapeutic strategies for castration resistant prostate cancer: inhibition of persistent androgen production and androgen receptor mediated signaling
    • Molina A, Belldegrun A. Novel therapeutic strategies for castration resistant prostate cancer: inhibition of persistent androgen production and androgen receptor mediated signaling. J Urol 2011; 185: 787-94.
    • (2011) J Urol , vol.185 , pp. 787-794
    • Molina, A.1    Belldegrun, A.2
  • 34
    • 77951518711 scopus 로고    scopus 로고
    • Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
    • Reid AH, Attard G, Danila DC etal. Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol 2010; 28: 1489-95.
    • (2010) J Clin Oncol , vol.28 , pp. 1489-1495
    • Reid, A.H.1    Attard, G.2    Danila, D.C.3
  • 35
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
    • Danila DC, Morris MJ, De Bono JS etal. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. J Clin Oncol 2010; 28: 1496-501.
    • (2010) J Clin Oncol , vol.28 , pp. 1496-1501
    • Danila, D.C.1    Morris, M.J.2    De Bono, J.S.3
  • 36
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • De Bono JS, Logothetis CJ, Molina A etal. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364: 1995-2005.
    • (2011) N Engl J Med , vol.364 , pp. 1995-2005
    • De Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 37
    • 84857594034 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Abiraterone acetate in asymptomatic or mildly symptomatic patients with metastatic castration-resistant prostate cancer. NCT00887198; [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Abiraterone acetate in asymptomatic or mildly symptomatic patients with metastatic castration-resistant prostate cancer. NCT00887198; 2009. [cited 16 Aug 2011]. Available from: .
    • (2009)
  • 38
    • 84857557320 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Abiraterone acetate in treating patients with prostate cancer who have undergone initial hormone therapy. Study NCT01309672; [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Abiraterone acetate in treating patients with prostate cancer who have undergone initial hormone therapy. Study NCT01309672; 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 39
    • 84857547492 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. IMAAGEN: impact of abiraterone acetate in prostate-specific antigen. Study NCT01314118; [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. IMAAGEN: impact of abiraterone acetate in prostate-specific antigen. Study NCT01314118; 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 40
    • 84857547497 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Maximum androgen depletion. Study NCT01254864: [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Maximum androgen depletion. Study NCT01254864: 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 41
    • 84857557318 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Study of abiraterone acetate in patients with advanced prostate cancer. Study NCT01217697. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Study of abiraterone acetate in patients with advanced prostate cancer. Study NCT01217697. 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 42
    • 84857557319 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Abiraterone post ketoconazole. Study NCT01199146. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Abiraterone post ketoconazole. Study NCT01199146. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 43
    • 84857594028 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Neo-adjuvant abiraterone+luteinizing hormone-releasing hormone (LHRH) versus LHRH in prostate cancer. Study NCT01088529. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Neo-adjuvant abiraterone+luteinizing hormone-releasing hormone (LHRH) versus LHRH in prostate cancer. Study NCT01088529. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 44
    • 84857594027 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Abiraterone acetate, prednisone, and leuprolide acetate or goserelin before and during radiation therapy in treating patients with localized or locally advanced prostate cancer. Study NCT01023061: [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Abiraterone acetate, prednisone, and leuprolide acetate or goserelin before and during radiation therapy in treating patients with localized or locally advanced prostate cancer. Study NCT01023061: 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 45
    • 84857562476 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Neoadjuvant abiraterone acetate plus leuprolide acetate in men with localized high risk prostate cancer. Study NCT00924469. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Neoadjuvant abiraterone acetate plus leuprolide acetate in men with localized high risk prostate cancer. Study NCT00924469. 2009. [cited 16 Aug 2011]. Available from: .
    • (2009)
  • 46
    • 84857547495 scopus 로고    scopus 로고
    • RANKL-targeted therapies: the next frontier in the treatment of male osteoporosis
    • DOI 10.4061/2011/941310 [Epub ahead of print].
    • Morgans AK, Smith MR. RANKL-targeted therapies: the next frontier in the treatment of male osteoporosis. J Osteoporos 2011; 2011: 941310. DOI 10.4061/2011/941310 [Epub ahead of print].
    • (2011) J Osteoporos , vol.2011 , pp. 941310
    • Morgans, A.K.1    Smith, M.R.2
  • 47
    • 80053077567 scopus 로고    scopus 로고
    • Emerging therapies to prevent skeletal morbidity in men with prostate cancer
    • Saylor PJ, Lee RJ, Smith MR. Emerging therapies to prevent skeletal morbidity in men with prostate cancer. J Clin Oncol 2011; 29: 3705-14.
    • (2011) J Clin Oncol , vol.29 , pp. 3705-3714
    • Saylor, P.J.1    Lee, R.J.2    Smith, M.R.3
  • 48
    • 69049105440 scopus 로고    scopus 로고
    • Denosumab in men receiving androgen-deprivation therapy for prostate cancer
    • Smith MR, Egerdie B, Hernandez TN etal. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009; 361: 745-55.
    • (2009) N Engl J Med , vol.361 , pp. 745-755
    • Smith, M.R.1    Egerdie, B.2    Hernandez, T.N.3
  • 49
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
    • Fizazi K, Carducci M, Smith M etal. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet 2011; 377: 813-22.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 50
    • 20644447798 scopus 로고    scopus 로고
    • First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
    • Nilsson S, Larsen RH, Fossa SD etal. First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases. Clin Cancer Res 2005; 11: 4451-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 4451-4459
    • Nilsson, S.1    Larsen, R.H.2    Fossa, S.D.3
  • 51
    • 34347244905 scopus 로고    scopus 로고
    • Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
    • Nilsson S, Franzen L, Parker C etal. Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study. Lancet Oncol 2007; 8: 587-94.
    • (2007) Lancet Oncol , vol.8 , pp. 587-594
    • Nilsson, S.1    Franzen, L.2    Parker, C.3
  • 52
    • 84856406453 scopus 로고    scopus 로고
    • TM) in the treatment of patients with symptomatic bone metastases in castration-resistant prostate cancer (CRPC): a phase III randomized trial (ALSYMPICA)
    • Abstract: 1LBA.
    • TM) in the treatment of patients with symptomatic bone metastases in castration-resistant prostate cancer (CRPC): a phase III randomized trial (ALSYMPICA). Eur J Cancer 2011; 47 (Suppl. 2): 3. Abstract: 1LBA.
    • (2011) Eur J Cancer , vol.47 , Issue.2 SUPPL. , pp. 3
    • Parker, C.1    Heinrich, D.2    O'Sullivan, J.M.3
  • 53
    • 84857594030 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. A study of Alpharadin® with docetaxel in patients with bone metastasis from castration-resistant prostate cancer (CRPC). Study NCT01106352. [cited 1 Nov 2011]. Available from:
    • NIH Clinical Trials Database. A study of Alpharadin® with docetaxel in patients with bone metastasis from castration-resistant prostate cancer (CRPC). Study NCT01106352. 2010. [cited 1 Nov 2011]. Available from: .
    • (2010)
  • 54
    • 84857547496 scopus 로고    scopus 로고
    • A randomized phase II study of ipilimumab with androgen ablation compared with androgen ablation alone in patients with advanced prostate cancer. Presented at ASCO 2010 Genitourinary Cancers Symposium [Abstract number 168].
    • Tollefson MK, Karnes RJ, Thompson RH etal. A randomized phase II study of ipilimumab with androgen ablation compared with androgen ablation alone in patients with advanced prostate cancer. Presented at ASCO 2010 Genitourinary Cancers Symposium [Abstract number 168]. 2010.
    • (2010)
    • Tollefson, M.K.1    Karnes, R.J.2    Thompson, R.H.3
  • 55
    • 84857557321 scopus 로고    scopus 로고
    • Conversion of advanced prostate cancer to organ-confined minimal residual disease using CTLA-4 blockade (ipilimumab) immunotherapy. Poster presented at ASCO 2010 Genitourinary Cancers Symposium Abstract 33.
    • Granberg C, Karnes RJ, Tollefson MK etal. Conversion of advanced prostate cancer to organ-confined minimal residual disease using CTLA-4 blockade (ipilimumab) immunotherapy. Poster presented at ASCO 2010 Genitourinary Cancers Symposium Abstract 33. 2010.
    • (2010)
    • Granberg, C.1    Karnes, R.J.2    Tollefson, M.K.3
  • 56
    • 84857594031 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Neoadjuvant ipilimumab in prostate cancer. Study NCT01194271. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Neoadjuvant ipilimumab in prostate cancer. Study NCT01194271. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 57
    • 84857557322 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Study of immunotherapy to treat advanced prostate cancer. Study NCT00861614. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Study of immunotherapy to treat advanced prostate cancer. Study NCT00861614. 2009. [cited 16 Aug 2011]. Available from: .
    • (2009)
  • 58
    • 84857594032 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Phase 3 study of immunotherapy to treat advanced prostate cancer. Study NCT01057810. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Phase 3 study of immunotherapy to treat advanced prostate cancer. Study NCT01057810. 2010. [cited 16 Aug 2011]. Available from:
    • (2010)
  • 59
    • 70249148660 scopus 로고    scopus 로고
    • Immunotherapy for prostate cancer: walk, don't run
    • Drake CG. Immunotherapy for prostate cancer: walk, don't run. J Clin Oncol 2009; 27: 4035-7.
    • (2009) J Clin Oncol , vol.27 , pp. 4035-4037
    • Drake, C.G.1
  • 60
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ etal. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324: 787-90.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3
  • 61
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
    • Scher HI, Beer TM, Higano CS etal. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010; 375: 1437-46.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3
  • 62
    • 84857547498 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Safety and efficacy study of MDV3100 in patients with castration-resistant prostate cancer who have been previously treated with docetaxel-based chemotherapy (AFFIRM). Study NCT00974311. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Safety and efficacy study of MDV3100 in patients with castration-resistant prostate cancer who have been previously treated with docetaxel-based chemotherapy (AFFIRM). Study NCT00974311. 2009. [cited 16 Aug 2011]. Available from: .
    • (2009)
  • 63
    • 84857562477 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. A safety and efficacy study of oral MDV3100 in chemotherapy-naive patients with progressive metastatic prostate cancer (PREVAIL). Study NCT01212991. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. A safety and efficacy study of oral MDV3100 in chemotherapy-naive patients with progressive metastatic prostate cancer (PREVAIL). Study NCT01212991. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 64
    • 84857557323 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. A study to test if MDV3100 is effective and safe in prostate cancer patients who have never had hormone therapy. Study NCT01302041. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. A study to test if MDV3100 is effective and safe in prostate cancer patients who have never had hormone therapy. Study NCT01302041. 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 65
    • 84857547499 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. A study of MDV3100 versus bicalutamide in castrate men with metastatic prostate cancer. Study NCT01288911. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. A study of MDV3100 versus bicalutamide in castrate men with metastatic prostate cancer. Study NCT01288911. 2011. [cited 16 Aug 2011]. Available from: .
    • (2011)
  • 66
    • 84857547500 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Study comparing orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer. Study NCT01193244. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Study comparing orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer. Study NCT01193244. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 67
    • 84857562481 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Study comparing orteronel plus prednisone in patients with metastatic castration-resistant prostate cancer. Study NCT01193257. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Study comparing orteronel plus prednisone in patients with metastatic castration-resistant prostate cancer. Study NCT01193257. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 68
    • 84857594033 scopus 로고    scopus 로고
    • NIH Clinical Trials Database. Study of TAK-700 in combination with docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Study NCT01084655. [cited 16 Aug 2011]. Available from:
    • NIH Clinical Trials Database. Study of TAK-700 in combination with docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Study NCT01084655. 2010. [cited 16 Aug 2011]. Available from: .
    • (2010)
  • 69
    • 84857562480 scopus 로고    scopus 로고
    • Note
    • NIH Clinical Trials Database. Safety and efficacy study of TAK-700 in patients with nonmetastatic castration-resistant prostate cancer and a rising prostate-specific antigen. Study NCT01046916: 2010. [cited 16 Aug 2011]. Available from: .


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.