ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Girgenti, Matthew J ^a   LoTurco, Joseph J ^a   Maher, Brady J ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GREEN FLUORESCENT PROTEIN; CATECHOL METHYLTRANSFERASE; DOPAMINE 2 RECEPTOR; KRUPPEL LIKE FACTOR; PDE4B PROTEIN, HUMAN; PHOSPHODIESTERASE IV; PRSS16 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SERINE PROTEINASE; ZNF804A PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; COMT GENE; CONTROLLED STUDY; DRD2 GENE; EMBRYO; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC TRANSFECTION; IN VIVO STUDY; NERVE CELL CULTURE; NEURAL STEM CELL; NONHUMAN; PDE4B GENE; PROMOTER REGION; PRSS16 GENE; RAT; SCHIZOPHRENIA; TRANSCRIPTION REGULATION; UPREGULATION; ZNF804A GENE; ANIMAL; BINDING SITE; BIOSYNTHESIS; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; PHYSIOLOGY; STEM CELL;

RATTUS;

ANIMALS; BINDING SITES; CATECHOL O-METHYLTRANSFERASE; CELL NUCLEUS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNOHISTOCHEMISTRY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; RATS; RECEPTORS, DOPAMINE D2; RECOMBINANT PROTEINS; SCHIZOPHRENIA; SERINE ENDOPEPTIDASES; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 84857522446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032404     Document Type: Article

References (18)

1. Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, et al. (2010) Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PLoS One 5: e10789.
2. Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, et al. (2007) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry 12: 74-86.
3. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, et al. (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40: 1053-1055.
4. Riley B, Thiselton D, Maher BS, Bigdeli T, Wormley B, et al. (2010) Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry 15: 29-37.
5. Steinberg S, Mors O, Borglum AD, Gustafsson O, Werge T, et al. (2011) Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry 16: 59-66.
6. Zhang R, Lu SM, Qiu C, Liu XG, Gao CG, et al. (2011) Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol Psychiatry 16: 360-361.
7. Zhang F, Chen Q, Ye T, Lipska BK, Straub RE, et al. (2011) Evidence of sex-modulated association of ZNF804A with schizophrenia. Biol Psychiatry 69: 914-917.
8. Zhang R, Valenzuela RK, Lu S, Meng L, Guo T, et al. (2011) Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophr Res.
9. Williams HJ, Norton N, Dwyer S, Moskvina V, Nikolov I, et al. (2011) Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry 16: 429-441.
10. Hill MJ, Bray NJ, (2011) Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A. Mol Psychiatry.
11. Hill MJ, Jeffries AR, Dobson RJ, Price J, Bray NJ, (2011) Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Hum Mol Genet.
12. Lewis DA, Levitt P, (2002) Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25: 409-432.
13. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, et al. (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40: 827-834.
14. Tunbridge EM, Harrison PJ, Weinberger DR, (2006) Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 60: 141-151.
15. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, et al. (2009) Common variants conferring risk of schizophrenia. Nature 460: 744-747.
16. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, et al. (2009) Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 460: 753-757.
17. Bowlus CL, Ahn J, Chu T, Gruen JR, (1999) Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cell Immunol 196: 80-86.
18. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, et al. (2004) Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 61: 774-780.