The max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Montagne, Martin ^a   Beaudoin, Nicolas ^a   Fortin, David ^a   Lavoie, Christine L ^a   Klinck, Roscoe ^a   Lavigne, Pierre ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; MAX PROTEIN; MYC PROTEIN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; COMPLEMENTARY DNA; MYC ASSOCIATED FACTOR X; OMOMYC PROTEIN; PEPTIDE FRAGMENT; TRANSCRIPTION FACTOR; TRANSFERRIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MEMBRANE; CELL METABOLISM; CELL NUCLEUS; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOCYTOSIS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE TRANSLOCATION; GENETIC TRANSDUCTION; HELA CELL; HUMAN; HUMAN CELL; PHENOTYPIC VARIATION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CELL CYCLE; CHEMISTRY; CONFOCAL MICROSCOPY; DIMERIZATION; GENETIC TRANSCRIPTION; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; APOPTOSIS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL CYCLE; CELL PROLIFERATION; DIMERIZATION; DNA, COMPLEMENTARY; ENDOCYTOSIS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFERRIN;

EID: 84857497763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032172     Document Type: Article

References (37)

1. Cole MD, Nikiforov MA, (2006) Transcriptional activation by the Myc oncoprotein. Curr Top Microbiol. Immunol 302: 33-50.
2. Kleine-Kohlbrecher D, Adhikary S, Eilers M, (2006) Mechanisms of transcriptional repression by Myc. Curr Top Microbiol. Immunol 302: 51-62.
3. Rottmann S, Luscher B, (2006) The Mad side of the Max network: antagonizing the function of Myc and more. Curr Top Microbiol. Immunol 302: 63-122.
4. Kime L, Wright SC, (2003) Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. Biochem J 370: 291-298 doi:10.1042/BJ20021679.
5. Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, et al. (1993) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72: 233-245.
6. Ayer DE, Kretzner L, Eisenman RN, (1993) Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72: 211-222.
7. Zervos AS, Gyuris J, Brent R, (1993) Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72: 223-232.
8. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H, (1990) Sequence-specific DNA binding by the c-Myc protein. Science 250: 1149-1151.
9. Blackwood EM, Eisenman RN, (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211-1217.
10. Gu W, Cechova K, Tassi V, Dalla-Favera R, (1993) Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc Natl Acad Sci USA 90: 2935-2939.
11. Lindeman GJ, Harris AW, Bath ML, Eisenman RN, Adams JM, (1995) Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice. Oncogene 10: 1013-1017.
12. Eilers M, Eisenman RN, (2008) Myc's broad reach. Genes & Development 22: 2755-2766 doi:10.1101/gad.1712408.
13. Yap CS, Peterson AL, Castellani G, Sedivy JM, Neretti N, (2011) Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle 10.
14. Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, et al. (1997) An alternative pathway for gene regulation by Myc. EMBO J 16: 5672-5686 doi:10.1093/emboj/16.18.5672.
15. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, et al. (2001) Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 3: 392-399 doi:10.1038/35070076.
16. Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, et al. (2001) TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 3: 400-408 doi:10.1038/35070086.
17. Wu S, Cetinkaya C, Munoz-Alonso MJ, Lehr von der N, Bahram F, et al. (2003) Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22: 351-360 doi:10.1038/sj.onc.1206145.
18. Seoane J, Le H-V, Massagué J, (2002) Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734 doi:10.1038/nature01119.
19. Yang W, Shen J, Wu M, Arsura M, FitzGerald M, et al. (2001) Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene 20: 1688-1702 doi:10.1038/sj.onc.1204245.
20. Bowen H, (2002) c-Myc Represses and Miz-1 Activates the Murine Natural Resistance-associated Protein 1 Promoter. Journal of Biological Chemistry 277: 34997-35006 doi:10.1074/jbc.M204232200.
21. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, et al. (2008) Modelling Myc inhibition as a cancer therapy. Nature 455: 679-683 doi:10.1038/nature07260.
22. Soucek L, Jucker R, Panacchia L, Ricordy R, Tatò F, et al. (2002) Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis. Cancer Research 62: 3507-3510.
23. Soucek L, Evan GI, (2010) The ups and downs of Myc biology. Curr Opin Genet Dev 20: 91-95 doi:10.1016/j.gde.2009.11.001.
24. Savino M, Annibali D, Carucci N, Favuzzi E, Cole MD, et al. (2011) The action mechanism of the myc inhibitor termed omomyc may give clues on how to target myc for cancer therapy. PLoS ONE 6: e22284 doi:10.1371/journal.pone.0022284.
25. Noguchi H, Bonner-Weir S, Wei F-Y, Matsushita M, Matsumoto S, (2005) BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54: 2859-2866.
26. Kato GJ, Lee WM, Chen LL, Dang CV, (1992) Max: functional domains and interaction with c-Myc. Genes & Development 6: 81-92.
27. Jiao CY, Delaroche D, Burlina F, Alves ID, Chassaing G, et al. (2009) Translocation and endocytosis for cell-penetrating peptide internalization. Journal of Biological Chemistry 284: 33957-33965 doi:10.1074/jbc.M109.056309.
28. Conner SD, Schmid SL, (2003) Regulated portals of entry into the cell. Nature 422: 37-44 doi:10.1038/nature01451.
29. Song BD, Yarar D, Schmid SL, (2004) An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol. Biol. Cell 15: 2243-2252 doi:10.1091/mbc.E04-01-0015.
30. Song BD, Leonard M, Schmid SL, (2004) Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem 279: 40431-40436 doi:10.1074/jbc.M407007200.
31. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, et al. (2006) Dynasore, a cell-permeable inhibitor of dynamin. Developmental Cell 10: 839-850 doi:10.1016/j.devcel.2006.04.002.
32. van den Berg A, Dowdy SF, (2011) Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol doi:10.1016/j.copbio.2011.03.008.
33. O'Connell BC, Cheung AF, Simkevich CP, Tam W, Ren X, et al. (2003) A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem 278: 12563-12573 doi:10.1074/jbc.M210462200.
34. Soucek L, Helmer-Citterich M, Sacco A, Jucker R, Cesareni G, et al. (1998) Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 17: 2463-2472 doi:10.1038/sj.onc.1202199.
35. Sodir NM, Swigart LB, Karnezis AN, Hanahan D, Evan GI, et al. (2011) Endogenous Myc maintains the tumor microenvironment. Genes & Development 25: 907-916 doi:10.1101/gad.2038411.
36. Jean-François N, Frédéric G, Raymund W, Benoit C, Lavigne P, (2003) Improving the Thermodynamic Stability of the Leucine Zipper of Max Increases the Stability of its b-HLH-LZ:E-box complex. J Mol Biol 326: 1577-1595 doi:10.1016/S0022-2836(03)00029-9.
37. Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J, (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8: R19 doi:10.1186/gb-2007-8-2-r19.