Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: A MITO-9 retrospective study

International Journal of Gynecological Cancer

Volumn 21, Issue 8, 2011, Pages 1414-1421

  Mangili, Giorgia ^a   Sigismondi, Cristina ^a   Gadducci, Angiolo ^b   Cormio, Gennaro ^c   Scollo, Paolo ^d   Tateo, Saverio ^e   Ferrandina, Gabriella ^f   Greggi, Stefano ^g   Candiani, Massimo ^a   Lorusso, Domenica ^h  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d CANNIZZARO HOSPITAL   (Italy)

^e FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

^g NATIONAL CANCER INSTITUTE   (Italy)

^h CATHOLIC UNIVERSITY   (Italy)

Author keywords

Chemotherapy; Malignant ovarian germ cell tumors; Prognostic factors; Recurrence; Surgical treatment

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CHILD; DYSGERMINOMA; EMBRYONAL CARCINOMA; FEMALE; FEMALE FERTILITY; FOLLOW UP; GERM CELL TUMOR; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; MIXED TUMOR; MULTICENTER STUDY; OUTCOME ASSESSMENT; OVARY TERATOMA; OVERALL SURVIVAL; PATHOLOGY; PATIENT REFERRAL; PREDICTOR VARIABLE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SALVAGE THERAPY; SCHOOL CHILD; TUMOR RECURRENCE; YOLK SAC TUMOR; CLINICAL TRIAL; ITALY; MIDDLE AGED; MORTALITY; NEOPLASM; OVARY; OVARY TUMOR; PROGNOSIS;

ADOLESCENT; ADULT; AGED; CHILD; FEMALE; HUMANS; ITALY; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, GERM CELL AND EMBRYONAL; OVARIAN NEOPLASMS; OVARY; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84857467744     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e3182236582     Document Type: Article

References (25)

1. Smith HO, Berwick M, Verschraegen CF, et al. Incidence and survival rates for female malignant germ cell tumors. Obstet Gynecol. 2006;107:1075-1085.
2. Tewari K, Cappuccini F, Disaia PJ, et al. Malignant germ cell tumors of the ovary. Obstet Gynecol. 2000;95:128-133. (Pubitemid 30001642)
3. Gershenson DM. Update on malignant ovarian germ cell tumors. Cancer. 1993;71:1581-1590. (Pubitemid 23056077)
4. Lu KH, Gershenson DM. Update on the management of ovarian germ cell tumors. J Reprod Med. 2005;50:417-425. (Pubitemid 40863958)
5. Williams SD. Treatment of germ cell tumors of the ovary. Semin Oncol. 1991;18:292-296.
6. Low JJ, Perrin LC, Crandon AJ, et al. Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. A review of 74 cases. Cancer. 2000;89:391-398. (Pubitemid 30489889)
7. Mitchell MF, Gershenson DM, Soeters RP, et al. The long-term effects of radiation therapy on patients with ovarian dysgerminoma. Cancer. 1991;67:1084-1090.
8. Gershenson DM. Management of ovarian germ cell tumors. J Clin Oncol. 2007;25:2938-2943. (Pubitemid 47123158)
9. Colombo N, Peiretti M, Castiglione M. Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2009;4:24-26.
10. Mangili G, Scarfone G, Gadducci A, et al. Is adjuvant chemotherapy indicated in stage I pure immature ovarian teratoma (IT)? A multicentre Italian trial in ovarian cancer (MITO-9). Gynecol Oncol. 2010;119:48-52.
11. Gershenson DM, Miller AM, Champion VL, et al. Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. J Clin Oncol. 2007;25:2792-2797. (Pubitemid 47123188)
12. Zanetta G, Bonazzi C, Cantu M, et al. Survival and reproductive function after treatment of malignant germ cell ovarian tumors. J Clin Oncol. 2001;19:1015-1020. (Pubitemid 32176276)
13. Tangir J, Zelterman D, Ma W, et al. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101:251-257. (Pubitemid 36170125)
14. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer. 1976;37:2359-2372.
15. Robboy SJ, Scully RE. Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum Pathol. 1970;1:643-653.
16. FIGO committee on gynecologic oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet. 2009;105:3-4.
17. Gershenson DM. Management of early ovarian cancer: germ cell and sex cord-stromal tumors. Gynecol Oncol. 1994;55: S62-S72.
18. Topuz S, Iyibozkurt AC, Akhan SE, et al. Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. Eur J Gynaecol Oncol. 2008;29:635-637.
19. Tangjitgamol S, Hanprasertpong J, Manusirivithaya S, et al. Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. Acta Obstet Gynecol Scand. 2010;89:182-189.
20. Zanagnolo V, Sartori E, Galleri G, et al. Clinical review of 55 cases of malignant ovarian germ cell tumors. Eur J Gynaecol Oncol. 2004;25:315-320. (Pubitemid 38585613)
21. Pectasides D, Pectasides E, Kassanos D. Germ cell tumors of the ovary. Cancer Treat Rev. 2008;34:427-441.
22. Norris HJ, Jensen RD. Relative frequency of ovarian neoplasms in children and adolescents. Cancer. 1972;30:713-719.
23. Quirk JT, Natarajan N, Mettlin CJ. Age-specific ovarian cancer incidence rate patterns in the United States. Gynecol Oncol. 2005;99:248-250. (Pubitemid 41354614)
24. Lee KH, Lee IH, Kim BG, et al. Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. Int J Gynecol Cancer. 2009;19:84-87.
25. Chan JK, Tewari KS, Waller S, et al. The influence of conservative surgical practices for malignant ovarian germ cell tumors. J Surg Oncol. 2008;98:111-116.