Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children

Burns

Volumn 38, Issue 2, 2012, Pages 236-246

  Zhang, Zhi ^a   Finnerty, Celeste C ^b   He, Jing ^b   Herndon, David N ^b  

^a JINAN UNIVERSITY   (China)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Hypertrophic scar; Smad ubiquitination regulatory factor 2; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; SMAD PROTEIN; SMAD UBIQUITINATION REGULATORY FACTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BURN; CHILD; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC SCAR; MALE; PRESCHOOL CHILD; PROTEIN EXPRESSION; SCHOOL CHILD; SIGNAL TRANSDUCTION;

ACTINS; BLOTTING, WESTERN; BURNS; CELLS, CULTURED; CICATRIX, HYPERTROPHIC; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES;

EID: 84857453516     PISSN: 03054179     EISSN: 18791409     Source Type: Journal    
DOI: 10.1016/j.burns.2011.08.012     Document Type: Article

References (44)

1. P.G. Scott, A. Ghahary, and E.E. Tredget Molecular and cellular aspects of fibrosis following thermal injury Hand Clin 16 2 2000 271 287 (Pubitemid 30219987)
2. G.C. Blobe, W.P. Schiemann, and H.F. Lodish Role of transforming growth factor beta in human disease N Engl J Med 342 18 2000 1350 1358 (Pubitemid 30408720)
3. F.B. Niessen, P.H. Spauwen, J. Schalkwijk, and M. Kon On the nature of hypertrophic scars and keloids: a review Plast Reconstr Surg 104 5 1999 1435 1458 (Pubitemid 29466295)
4. J.K. Jutley, E.J. Wood, and W.J. Cunliffe Influence of retinoic acid and TGF-beta on dermal fibroblast proliferation and collagen production in monolayer cultures and dermal equivalents Matrix 13 May (3) 1993 235 241 (Pubitemid 23136509)
5. A. Desmoulire, A. Geinoz, F. Gabbiani, and G. Gabbiani Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts J Cell Biol 122 July (1) 1993 103 111 (Pubitemid 23188802)
6. Z. Zhang, X.J. Li, Y. Liu, X. Zhang, Y.Y. Li, and W.S. Xu Recombinant human decorin inhibits cell proliferation and downregulates TGF-beta1 production in hypertrophic scar fibroblasts Burns 33 August (5) 2007 634 641 (Pubitemid 46880036)
7. A. Moustakas, S. Souchelnytskyi, and C.H. Heldin Smad regulation in TGF-beta signal transduction J Cell Sci 114 Pt 24 2001 4359 4369 (Pubitemid 34082857)
8. Y. Shi, and J. Massague Mechanisms of TGF-β1eta signaling from cell membrane to the nucleus Cell 113 June (6) 2003 685 700 (Pubitemid 36724933)
9. L. Izzi, and L. Attisano Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation Oncogene 23 March (11) 2004 2071 2078 (Pubitemid 38496736)
10. Y. Cai, X.Z. Shen, C.H. Zhou, and J.Y. Wang Abnormal expression of Smurf2 during the process of rat liver fibrosis Chin J Dig Dis 7 4 2006 237 245
11. E.A. Renzoni, D.J. Abraham, S. Howat, X. Shi-Wen, P. Sestini, and G. Bou-Gharios Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts Respir Res 5 November (30) 2004 24
12. H. Fukasawa, T. Yamamoto, A. Togawa, N. Ohashi, Y. Fujigaki, and T. Oda Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice Proc Natl Acad Sci USA 101 June (23) 2004 8687 8692 (Pubitemid 38745832)
13. H. Fukasawa, T. Yamamoto, A. Togawa, N. Ohashi, Y. Fujigaki, and T. Oda Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury Kidney Int 69 May (10) 2006 1733 1740 (Pubitemid 43739199)
14. A. Ghahary, Y.J. Shen, P.G. Scott, Y. Gong, and E.E. Tredget Enhanced expression of mRNA for transforming growth factor-beta, type I and type III procollagen in human post-burn hypertrophic scar tissues J Lab Clin Med 122 4 1993 465 473 (Pubitemid 23346783)
15. E.E. Tredget, R. Wang, Q. Shen, P.G. Scott, and A. Ghahary Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo J Interferon Cytokine Res 20 February (2) 2000 143 151 (Pubitemid 30123742)
16. R. Wang, A. Ghahary, Q. Shen, P.G. Scott, K. Roy, and E.E. Tredget Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells Wound Repair Regen 8 2 2000 128 137 (Pubitemid 30238326)
17. P.G. Scott, C.M. Dodd, E.E. Tredget, A. Ghahary, and F. Rahemtulla Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scars Histopathology 26 5 1995 423 431
18. M. Shah, D.M. Foreman, and M.W. Ferguson Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring J Cell Sci 108 Pt 3 1995 985 1002
19. M. Shah, D.M. Foreman, and M.W. Ferguson Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents J Cell Sci 107 Pt 5 1994 1137 1157
20. J. Massagué How cells read TGF-beta signals Nat Rev Mol Cell Biol 1 December (3) 2000 169 178
21. J.L. Wrana Regulation of Smad activity Cell 100 January (2) 2000 189 192 (Pubitemid 30064906)
22. K. Luo Ski and SnoN: negative regulators of TGF-beta signaling Curr Opin Genet Dev 14 1 2004 65 70 (Pubitemid 38167479)
23. R. Derynck, and Y.E. Zhang Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 October (6958) 2003 577 584 (Pubitemid 37280136)
24. M. Datto, and X.F. Wang Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling Cell 121 April (1) 2005 2 4
25. S. Itoh, and P. ten Dijke Negative regulation of TGF-β1 receptor/Smad signal transduction Curr Opin Cell Biol 19 April (2) 2007 176 184 (Pubitemid 46386411)
26. P. Kavsak, R.K. Rasmussen, C.G. Causing, S. Bonni, H. Zhu, and G.H. Thomsen Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Mol Cell 6 December (6) 2000 1365 1375 (Pubitemid 32045929)
27. P.A. Chong, H. Lin, J.L. Wrana, and J.D. Forman-Kay An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2 J Biol Chem 281 June (25) 2006 17069 17075
28. S. Bonni, H.R. Wang, C.G. Causing, P. Kavsak, S.L. Stroschein, and K. Luo TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Nat Cell Biol 3 June (6) 2001 587 595 (Pubitemid 32536856)
29. Y. Asano, H. Ihn, K. Yamane, M. Kubo, and K. Tamaki Impaired Smad7-Smurf-mediated negative regulation of TGF-β1eta signaling in scleroderma fibroblasts J Clin Invest 113 January (2) 2004 253 264 (Pubitemid 38544210)
30. M.J. Zuscik, R.N. Rosier, and E.M. Schwarz Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease Arthritis Rheum 48 July (7) 2003 1779 1780 (Pubitemid 36828670)
31. J. Yang, X. Zhang, Y. Li, and Y. Liu Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling J Am Soc Nephrol 14 December (12) 2003 3167 3177 (Pubitemid 38312571)
32. P. Schmid, P. Itin, G. Cherry, C. Bi, and D.A. Cox Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar Am J Pathol 152 February (2) 1998 485 493 (Pubitemid 28106395)
33. G. Dabiri, D.A. Tumbarello, C.E. Turner, and L. Van de Water Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop J Invest Dermatol 128 October (10) 2008 2518 2525
34. P. Martin Wound healing - aiming for perfect skin regeneration Science 276 5309 1997 75 81 (Pubitemid 27161246)
35. I. Darby, O. Skalli, and G. Gabbiani Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing Lab Invest 63 July (1) 1990 21 29 (Pubitemid 20234670)
36. H.P. Ehrlich, A. Desmoulire, R.F. Diegelmann, I.K. Cohen, C.C. Compton, and W.L. Garner Morphological and immunochemical differences between keloid and hypertrophic scar Am J Pathol 145 July (1) 1994 105 113 (Pubitemid 24217489)
37. B. Hinz Formation and function of the myofibroblast during tissue repair J Invest Dermatol 127 March (3) 2007 526 537
38. J.J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, and R.A. Brown Myofibroblasts and mechano-regulation of connective tissue remodelling Nat Rev Mol Cell Biol 3 May (5) 2002 349 363 (Pubitemid 34619269)
39. T.L. Tuan, and L.S. Nichter The molecular basis of keloid and hypertrophic scar formation Mol Med Today 4 1 1998 19 24 (Pubitemid 28124795)
40. K. Zhang, W. Garner, L. Cohen, J. Rodriguez, and S. Phan Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar J Invest Dermatol 104 5 1995 750 754
41. E.E. Tredget, B. Nedelec, P.G. Scott, and A. Ghahary Hypertrophic scars, keloids, and contractures: the cellular and molecular basis for therapy Surg Clin North Am 77 June (3) 1997 701 730 (Pubitemid 27256042)
42. Y. Inagaki, S. Truter, and F. Ramirez Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site J Biol Chem 269 May (20) 1994 14828 14834
43. E. Chang, and H. Goldberg Requirements for transforming growth factor-beta regulation of the pro-alpha 2(I) collagen and plasminogen activator inhibitor-1 promoters J Biol Chem 270 Mar (9) 1995 4473 4477
44. S.J. Chen, W. Yuan, S. Lo, M. Trojanowska, and J. Varga Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta J Cell Physiol 183 June (3) 2000 381 392 (Pubitemid 30243869)