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Volumn 7, Issue 2, 2012, Pages

Lymphocyte subsets show different response patterns to in vivo bound natalizumab-a flow cytometric study on patients with multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; NATALIZUMAB; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

EID: 84857432729     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031784     Document Type: Article
Times cited : (22)

References (38)
  • 1
    • 33745809199 scopus 로고    scopus 로고
    • The impact of interferon-beta treatment on the blood-brain barrier
    • Kraus J, Oschmann P, (2006) The impact of interferon-beta treatment on the blood-brain barrier. Drug Discov Today 11: 755-762.
    • (2006) Drug Discov Today , vol.11 , pp. 755-762
    • Kraus, J.1    Oschmann, P.2
  • 2
    • 0037413240 scopus 로고    scopus 로고
    • Alpha4 integrins as therapeutic targets in autoimmune disease
    • von Andrian UH, Engelhardt B, (2003) Alpha4 integrins as therapeutic targets in autoimmune disease. N Engl J Med 348: 68-72.
    • (2003) N Engl J Med , vol.348 , pp. 68-72
    • von Andrian, U.H.1    Engelhardt, B.2
  • 3
    • 10344247674 scopus 로고    scopus 로고
    • Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS
    • Eikelenboom MJ, Killestein J, Izeboud T, Kalkers NF, Baars PA, et al. (2005) Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS. J Neuroimmunol 158: 222-230.
    • (2005) J Neuroimmunol , vol.158 , pp. 222-230
    • Eikelenboom, M.J.1    Killestein, J.2    Izeboud, T.3    Kalkers, N.F.4    Baars, P.A.5
  • 4
    • 78650970227 scopus 로고    scopus 로고
    • Adhesion molecules are promising candidates to establish surrogate markers for natalizumab treatment
    • Wipfler P, Oppermann K, Pilz G, Afazel S, Haschke-Becher E, et al. (2011) Adhesion molecules are promising candidates to establish surrogate markers for natalizumab treatment. Mult Scler 17: 16-23.
    • (2011) Mult Scler , vol.17 , pp. 16-23
    • Wipfler, P.1    Oppermann, K.2    Pilz, G.3    Afazel, S.4    Haschke-Becher, E.5
  • 5
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, et al. (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 356: 63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5
  • 6
    • 53049098138 scopus 로고    scopus 로고
    • Antigen-specific therapies in MS - Current concepts and novel approaches
    • Lutterotti A, Sospedra M, Martin R, (2008) Antigen-specific therapies in MS- Current concepts and novel approaches. J Neurol Sci 274: 18-22.
    • (2008) J Neurol Sci , vol.274 , pp. 18-22
    • Lutterotti, A.1    Sospedra, M.2    Martin, R.3
  • 7
    • 78651365410 scopus 로고    scopus 로고
    • Recent developments in approved and oral multiple sclerosis treatment and an update on future treatment options
    • Wipfler P, Harrer A, Pilz G, Oppermann K, Trinka E, et al. (2011) Recent developments in approved and oral multiple sclerosis treatment and an update on future treatment options. Drug Discov Today 16: 8-21.
    • (2011) Drug Discov Today , vol.16 , pp. 8-21
    • Wipfler, P.1    Harrer, A.2    Pilz, G.3    Oppermann, K.4    Trinka, E.5
  • 8
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, Hutchinson M, Kappos L, et al. (2006) A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 354: 899-910.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3    Hutchinson, M.4    Kappos, L.5
  • 10
    • 55449137632 scopus 로고    scopus 로고
    • Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis
    • Krumbholz M, Meinl I, Kumpfel T, Hohlfeld R, Meinl E, (2008) Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71: 1350-1354.
    • (2008) Neurology , vol.71 , pp. 1350-1354
    • Krumbholz, M.1    Meinl, I.2    Kumpfel, T.3    Hohlfeld, R.4    Meinl, E.5
  • 11
    • 79957973246 scopus 로고    scopus 로고
    • Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients
    • Skarica M, Eckstein C, Whartenby KA, Calabresi PA, (2011) Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. J Neuroimmunol 235: 70-76.
    • (2011) J Neuroimmunol , vol.235 , pp. 70-76
    • Skarica, M.1    Eckstein, C.2    Whartenby, K.A.3    Calabresi, P.A.4
  • 12
    • 77956650118 scopus 로고    scopus 로고
    • Natalizumab treatment reduces endothelial activity in MS patients
    • Millonig A, Hegen H, Di Pauli F, Ehling R, Gneiss C, et al. (2010) Natalizumab treatment reduces endothelial activity in MS patients. J Neuroimmunol 227: 190-194.
    • (2010) J Neuroimmunol , vol.227 , pp. 190-194
    • Millonig, A.1    Hegen, H.2    Di Pauli, F.3    Ehling, R.4    Gneiss, C.5
  • 13
    • 26444598492 scopus 로고    scopus 로고
    • Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis
    • Stuve O, Cepok S, Elias B, Saleh A, Hartung HP, et al. (2005) Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch Neurol 62: 1620-1623.
    • (2005) Arch Neurol , vol.62 , pp. 1620-1623
    • Stuve, O.1    Cepok, S.2    Elias, B.3    Saleh, A.4    Hartung, H.P.5
  • 14
    • 61449227381 scopus 로고    scopus 로고
    • Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
    • del Pilar MM, Cravens PD, Winger R, Frohman EM, Racke MK, et al. (2008) Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol 65: 1596-1603.
    • (2008) Arch Neurol , vol.65 , pp. 1596-1603
    • del Pilar, M.M.1    Cravens, P.D.2    Winger, R.3    Frohman, E.M.4    Racke, M.K.5
  • 15
    • 0023860204 scopus 로고
    • Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy
    • Houff SA, Major EO, Katz DA, Kufta CV, Sever JL, et al. (1988) Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med 318: 301-305.
    • (1988) N Engl J Med , vol.318 , pp. 301-305
    • Houff, S.A.1    Major, E.O.2    Katz, D.A.3    Kufta, C.V.4    Sever, J.L.5
  • 16
    • 43549090004 scopus 로고    scopus 로고
    • The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans
    • Zohren F, Toutzaris D, Klarner V, Hartung HP, Kieseier B, et al. (2008) The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans. Blood 111: 3893-3895.
    • (2008) Blood , vol.111 , pp. 3893-3895
    • Zohren, F.1    Toutzaris, D.2    Klarner, V.3    Hartung, H.P.4    Kieseier, B.5
  • 17
    • 77949279537 scopus 로고    scopus 로고
    • Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
    • Clifford DB, De Luca A, Simpson DM, Arendt G, Giovannoni G, et al. (2010) Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol 9: 438-446.
    • (2010) Lancet Neurol , vol.9 , pp. 438-446
    • Clifford, D.B.1    De Luca, A.2    Simpson, D.M.3    Arendt, G.4    Giovannoni, G.5
  • 18
    • 34848816850 scopus 로고    scopus 로고
    • The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
    • Calabresi PA, Giovannoni G, Confavreux C, Galetta SL, Havrdova E, et al. (2007) The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 69: 1391-1403.
    • (2007) Neurology , vol.69 , pp. 1391-1403
    • Calabresi, P.A.1    Giovannoni, G.2    Confavreux, C.3    Galetta, S.L.4    Havrdova, E.5
  • 19
    • 84860396489 scopus 로고    scopus 로고
    • Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab
    • Sorensen PS, Jensen PE, Haghikia A, Lundkvist M, Vedeler C, et al. (2011) Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab. Mult Scler.
    • (2011) Mult Scler
    • Sorensen, P.S.1    Jensen, P.E.2    Haghikia, A.3    Lundkvist, M.4    Vedeler, C.5
  • 20
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"
    • Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, et al. (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 58: 840-846.
    • (2005) Ann Neurol , vol.58 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3    Filippi, M.4    Hartung, H.P.5
  • 21
    • 0031825481 scopus 로고    scopus 로고
    • Soluble and cell surface ICAM-1 as markers for disease activity in multiple sclerosis
    • Kraus J, Oschmann P, Engelhardt B, Schiel C, Hornig C, et al. (1998) Soluble and cell surface ICAM-1 as markers for disease activity in multiple sclerosis. Acta Neurol Scand 98: 102-109.
    • (1998) Acta Neurol Scand , vol.98 , pp. 102-109
    • Kraus, J.1    Oschmann, P.2    Engelhardt, B.3    Schiel, C.4    Hornig, C.5
  • 22
    • 0035673697 scopus 로고    scopus 로고
    • Soluble and cell surface bound adhesion molecules in blood and cerebrospinal fluid as diagnostic markers and parameters for disease activity, disease severity and treatment efficacy in patients with multiple sclerosis
    • Kraus J, Engelhardt B, Kuehne BS, Laske C, Stolz E, et al. (2001) Soluble and cell surface bound adhesion molecules in blood and cerebrospinal fluid as diagnostic markers and parameters for disease activity, disease severity and treatment efficacy in patients with multiple sclerosis. J Lab Med 25: 548-56.
    • (2001) J Lab Med , vol.25 , pp. 548-556
    • Kraus, J.1    Engelhardt, B.2    Kuehne, B.S.3    Laske, C.4    Stolz, E.5
  • 23
    • 79955661321 scopus 로고    scopus 로고
    • Natalizumab therapy decreases surface expression of both VLA-heterodimer subunits on peripheral blood mononuclear cells
    • Harrer A, Wipfler P, Einhaeupl M, Pilz G, Oppermann K, et al. (2011) Natalizumab therapy decreases surface expression of both VLA-heterodimer subunits on peripheral blood mononuclear cells. J Neuroimmunol 234: 148-154.
    • (2011) J Neuroimmunol , vol.234 , pp. 148-154
    • Harrer, A.1    Wipfler, P.2    Einhaeupl, M.3    Pilz, G.4    Oppermann, K.5
  • 24
    • 33646347357 scopus 로고    scopus 로고
    • Natalizumab effects on immune cell responses in multiple sclerosis
    • Niino M, Bodner C, Simard ML, Alatab S, Gano D, et al. (2006) Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol 59: 748-754.
    • (2006) Ann Neurol , vol.59 , pp. 748-754
    • Niino, M.1    Bodner, C.2    Simard, M.L.3    Alatab, S.4    Gano, D.5
  • 25
    • 3242789242 scopus 로고    scopus 로고
    • IFN-alpha subtypes differentially affect human T cell motility
    • Foster GR, Masri SH, David R, Jones M, Datta A, et al. (2004) IFN-alpha subtypes differentially affect human T cell motility. J Immunol 173: 1663-1670.
    • (2004) J Immunol , vol.173 , pp. 1663-1670
    • Foster, G.R.1    Masri, S.H.2    David, R.3    Jones, M.4    Datta, A.5
  • 26
    • 33749588466 scopus 로고    scopus 로고
    • Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    • Stuve O, Marra CM, Bar-Or A, Niino M, Cravens PD, et al. (2006) Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol 63: 1383-1387.
    • (2006) Arch Neurol , vol.63 , pp. 1383-1387
    • Stuve, O.1    Marra, C.M.2    Bar-Or, A.3    Niino, M.4    Cravens, P.D.5
  • 27
    • 0036008302 scopus 로고    scopus 로고
    • Differential expression of beta1 and beta2 integrins and L-selectin on CD4+ and CD8+ T lymphocytes in human blood: comparative analysis between isolated cells, whole blood samples and cryopreserved preparations
    • Cavers M, Afzali B, Macey M, McCarthy DA, Irshad S, et al. (2002) Differential expression of beta1 and beta2 integrins and L-selectin on CD4+ and CD8+ T lymphocytes in human blood: comparative analysis between isolated cells, whole blood samples and cryopreserved preparations. Clin Exp Immunol 127: 60-65.
    • (2002) Clin Exp Immunol , vol.127 , pp. 60-65
    • Cavers, M.1    Afzali, B.2    Macey, M.3    McCarthy, D.A.4    Irshad, S.5
  • 28
    • 0032526195 scopus 로고    scopus 로고
    • A role for natural killer cells in the immunopathogenesis of multiple sclerosis
    • Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, et al. (1998) A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol 86: 123-133.
    • (1998) J Neuroimmunol , vol.86 , pp. 123-133
    • Kastrukoff, L.F.1    Morgan, N.G.2    Zecchini, D.3    White, R.4    Petkau, A.J.5
  • 29
    • 0345303863 scopus 로고    scopus 로고
    • Clinical relapses of multiple sclerosis are associated with 'novel' valleys in natural killer cell functional activity
    • Kastrukoff LF, Lau A, Wee R, Zecchini D, White R, et al. (2003) Clinical relapses of multiple sclerosis are associated with 'novel' valleys in natural killer cell functional activity. J Neuroimmunol 145: 103-114.
    • (2003) J Neuroimmunol , vol.145 , pp. 103-114
    • Kastrukoff, L.F.1    Lau, A.2    Wee, R.3    Zecchini, D.4    White, R.5
  • 30
    • 0035874522 scopus 로고    scopus 로고
    • Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    • Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, et al. (2001) Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 97: 3146-3151.
    • (2001) Blood , vol.97 , pp. 3146-3151
    • Cooper, M.A.1    Fehniger, T.A.2    Turner, S.C.3    Chen, K.S.4    Ghaheri, B.A.5
  • 31
    • 37849032623 scopus 로고    scopus 로고
    • Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells
    • Airas L, Saraste M, Rinta S, Elovaara I, Huang YH, et al. (2008) Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells. Clin Exp Immunol 151: 235-243.
    • (2008) Clin Exp Immunol , vol.151 , pp. 235-243
    • Airas, L.1    Saraste, M.2    Rinta, S.3    Elovaara, I.4    Huang, Y.H.5
  • 32
    • 34447290007 scopus 로고    scopus 로고
    • Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta
    • Saraste M, Irjala H, Airas L, (2007) Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta. Neurol Sci 28: 121-126.
    • (2007) Neurol Sci , vol.28 , pp. 121-126
    • Saraste, M.1    Irjala, H.2    Airas, L.3
  • 33
    • 33645812129 scopus 로고    scopus 로고
    • Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    • Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, et al. (2006) Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A 103: 5941-5946.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5941-5946
    • Bielekova, B.1    Catalfamo, M.2    Reichert-Scrivner, S.3    Packer, A.4    Cerna, M.5
  • 34
  • 35
    • 33644865904 scopus 로고    scopus 로고
    • Early development of therapeutic biologics-pharmacokinetics
    • Baumann A, (2006) Early development of therapeutic biologics-pharmacokinetics. Curr Drug Metab 7: 15-21.
    • (2006) Curr Drug Metab , vol.7 , pp. 15-21
    • Baumann, A.1
  • 36
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: the neonatal Fc receptor comes of age
    • Roopenian DC, Akilesh S, (2007) FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7: 715-725.
    • (2007) Nat Rev Immunol , vol.7 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 37
    • 79952454134 scopus 로고    scopus 로고
    • Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody
    • Rispens T, Leeuwen A, Vennegoor A, Killestein J, Aalberse RC, et al. (2011) Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody. Anal Biochem 411: 271-276.
    • (2011) Anal Biochem , vol.411 , pp. 271-276
    • Rispens, T.1    Leeuwen, A.2    Vennegoor, A.3    Killestein, J.4    Aalberse, R.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.