Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes

Drug Metabolism and Disposition

Volumn 40, Issue 3, 2012, Pages 596-601

  Gates, Leah A ^a   Lu, Ding ^a,b   Peterson, Lisa A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL HYDROXYLASE; ACETYLCYSTEINE; ALDEHYDE DERIVATIVE; AMINO ACID; CIS 2 BUTENE 1,4 DIAL; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; FURAN; N ACETYL [1 (5 ACETYLAMINO 5 CARBOXYPENTYL) 1H PYRROL 3 YL]CYSTEINE; N ACETYL LYSINE; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; METABOLISM; MOUSE; NONHUMAN; OXIDATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SYNTHESIS; TANDEM MASS SPECTROMETRY; TOXICITY;

ACETYLCYSTEINE; ALDEHYDES; ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; FURANS; GLUTATHIONE; HUMANS; LYSINE; MICE; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXIDOREDUCTASES; RATS; TANDEM MASS SPECTROMETRY;

EID: 84857418739     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.043679     Document Type: Article

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