Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages

  Yasmin, Sabiha ^a,e   Alcazar Fuoli, Laura ^b   Grun̈dlinger, Mario ^a   Puempel, Thomas ^c   Cairns, Timothy ^b   Blatzer, Michael ^a   Lopez, Jordi F ^d   Grimalt, Joan O ^d   Bignell, Elaine ^b   Haas, Hubertus ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^e PAKISTAN COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH   (Pakistan)

Author keywords

Isoprenoide; Siderophore; Statins

Indexed keywords

ERGOSTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON; MEVALONIC ACID; MEVINOLIN; SIDEROPHORE;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; ENZYME ANALYSIS; ENZYME INACTIVATION; LIPID COMPOSITION; MICROBIAL GROWTH; MOUSE; MYCOSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VIRULENCE;

AMPHOTERICIN B; ANIMALS; ASPERGILLUS FUMIGATUS; BIOMASS; BIOSYNTHETIC PATHWAYS; ENOYL-COA HYDRATASE; ERGOSTEROL; FERRIC COMPOUNDS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; GENES, FUNGAL; HYDROXAMIC ACIDS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; IRON; LIGASES; LOVASTATIN; MEVALONIC ACID; MICE; MICROBIAL SENSITIVITY TESTS; OXIDATIVE STRESS; PULMONARY ASPERGILLOSIS; PYRIMIDINES; SIDEROPHORES; TRIAZOLES; UP-REGULATION; VIRULENCE;

EID: 84857404369     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106399108     Document Type: Article

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