Antibiotics in the Management of PROM and Preterm Labor

Obstetrics and Gynecology Clinics of North America

Volumn 39, Issue 1, 2012, Pages 65-76

  Mercer, Brian ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Antibiotics; Premature rupture of the membranes; Preterm labor; Preterm PROM

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; ANTIBIOTIC AGENT; CLINDAMYCIN; ERYTHROMYCIN; METRONIDAZOLE; PLACEBO;

AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; CHORIOAMNIONITIS; CONSERVATIVE TREATMENT; DRUG EFFICACY; FOLLOW UP; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INFECTION PREVENTION; NECROTIZING ENTEROCOLITIS; NEWBORN INFECTION; NEWBORN MORBIDITY; NEWBORN SEPSIS; PNEUMONIA; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; REVIEW; RISK REDUCTION;

ANTI-BACTERIAL AGENTS; CHORIOAMNIONITIS; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREMATURE BIRTH; UNITED STATES;

EID: 84857401064     PISSN: 08898545     EISSN: 15580474     Source Type: Journal    
DOI: 10.1016/j.ogc.2011.12.007     Document Type: Review

References (60)

1. Goldenberg R.L., Culhane J.F., Iams J.D., et al. Epidemiology and causes of preterm birth. Lancet 2008, 371:75-84.
2. Hillier S.L., Martius J., Krohn M., et al. A case-control study of chorioamnionitis infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988, 319:972-978.
3. Hillier S.L., Witkin S.S., Krohn M.A., et al. The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obstet Gynecol 1993, 81:941-948.
4. Gibbs R.S., Romero R., Hillier S.L., et al. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1991, 166:1515-1528.
5. Minkoff H. Prematurity: infection as an etiologic factor. Obstet Gynecol 1993, 62:137-144.
6. McDonald H.M., Brocklehurst P., Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2007, 1. CD00262.
7. Romero R., Oyarzun E., Mazor M., et al. Meta-Analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol 1989, 73:576-582.
8. Carey B.V., Eschenbach D.A., Nugent R.P., et al. A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. Am J Obstet Gynecol 1991, 164:734-742. Vaginal Infections and Prematurity Study Group.
9. Klebanoff M.A., Carey J.C., Hauth J.C., et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001, 345:487-493. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.
10. Andrews W.W., Goldenberg R.L., Hauth J.C., et al. Interconceptional antibiotics to prevent spontaneous preterm birth: a randomized clinical trial. Am J Obstet Gynecol 2006, 194:617-623.
11. Andrews W.W., Sibai B.M., Thom E.A., et al. Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin-positive women. Obstet Gynecol 2003, 101:847-855. National Institute of Child Health & Human Development Maternal-Fetal Medicine Units Network.
12. Broekhuizen F.F., Gilman M., Hamilton P.R. Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. Obstet Gynecol 1985, 66:316-321.
13. Cotton D.B., Hill L.M., Strassner H.T., et al. The use of amniocentesis in preterm gestation with ruptured membranes. Obstet Gynecol 1984, 63:38-43.
14. Zlatnik F.J., Cruickshank D.P., Petzold C.R., et al. Amniocentesis in the identification of inapparent infection in preterm patients with premature rupture of the membranes. J Reprod Med 1984, 29:656-660.
15. Mercer B., Moretti M., Rogers R., et al. Antibiotic prophylaxis in preterm premature rupture of the membranes: A prospective randomized double-blind trial of 220 patients. Am J Obstet Gynecol 1992, 166:794-802.
16. Romero R., Emamian M., Quintero R., et al. The value and limitations of the gram stain examination in the diagnosis of intra-amniotic infection. Am J Obstet Gynecol 1988, 159:114-119.
17. Wager G.P., Hanley L.S., Farb H.F., et al. Evaluation of gas-liquid chromatography for the rapid diagnosis of amniotic fluid infection: a preliminary report. Am J Obstet Gynecol 1985, 152:51-56.
18. Oh K.J., Lee K.A., Sohn Y.K., et al. Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 2010, 203:211.e1-211.e8.
19. DiGiulio D.B., Romero R., Kusanovic J.P., et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010, 64:38-57. 1.
20. Mercer B.M., Arheart K. Antimicrobial therapy in expectant management of preterm premature rupture of the membranes. Lancet 1995, 346:1271-1279.
21. Egarter C., Leitich H., Karas H., et al. Antibiotic treatment in preterm premature rupture of membranes and neonatal morbidity: a metaanalysis. Am J Obstet Gynecol 1996, 174:589-597.
22. Kenyon S., Boulvain M., Neilson J.P. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev 2010, 8. CD001058.
23. Mercer B., Miodovnik M., Thurnau G., et al. Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes: a randomized controlled trial. JAMA 1997, 278:989-995. NICHD-MFMU Network.
24. Lockwood C.J., Costigan K., Ghidini A., et al. Double-blind placebo-controlled trial of piperacillin prophylaxis in preterm membrane rupture. Am J Obstet Gynecol 1993, 169:970-976.
25. Amon E., Lewis S.V., Sibai B.M., et al. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol 1988, 159:539-543.
26. Johnston M.M., Sanchez-Ramos L., Vaughn A.J., et al. Antibiotic therapy in preterm premature rupture of the membranes: a randomized prospective double-blind trial. Am J Obstet Gynecol 1990, 163:743-747.
27. Christmas J.T., Cox S.M., Andrews W., et al. Expectant management of preterm ruptured membranes: Effects of antimicrobial therapy. Obstet Gynecol 1992, 80:759-762.
28. Owen J., Groome L.J., Hauth J.C. Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture. Am J Obstet Gynecol 1993, 169:976-981.
29. Fuhr N., Becker C., van Baalen A., et al. Antibiotic therapy for preterm premature rupture of membranes: results of a multicenter study. J Perinat Med 2006, 34:203-206.
30. Mercer B.M., Moretti M.L., Prevost R.R., et al. Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. Am J Obstet Gynecol 1992, 166:794-802.
31. Kenyon S.L., Taylor D.J., Tarnow-Mordi W. Broad spectrum antibiotics for preterm, prelabor rupture of fetal membranes: the ORACLE I Randomized trial. Lancet 2001, 357:979-988. Oracle Collaborative Group.
32. Kenyon S., Pike K., Jones D.R., et al. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Lancet 2008, 372:1310-1318.
33. Lewis D.F., Adair C.D., Robichaux A.G., et al. Antibiotic therapy in preterm premature rupture of membranes: are seven days necessary?. A preliminary, randomized clinical trial. Am J Obstet Gynecol 2003, 188:1413-1416.
34. Segel S.Y., Miles A.M., Clothier B., et al. Duration of antibiotic therapy after preterm premature rupture of fetal membranes. Am J Obstet Gynecol 2003, 189:799-802.
35. Skoll M.A., Moretti M.L., Sibai B.M. The incidence of positive amniotic fluid cultures in patients preterm labor with intact membranes. Am J Obstet Gynecol 1989, 161:813-816.
36. Romero R., Sirtori M., Oyarzun E., et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989, 161:817-824.
37. DiGiulio D.B., Romero R., Amogan H.P., et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One 2008, 3:e3056.
38. McGregor J.A., French J.I., Reller L.B., et al. Adjunctive erythromycin treatment for idiopathic preterm labor: results of a randomized, double-blinded placebo-controlled trial. Am J Obstet Gynecol 1986, 154:98-103.
39. McGregor J.A., French J.I., Seo K. Adjunctive clindamycin therapy for preterm labor results of a double-blind, placebo-controlled trial. Am J Obstet Gynecol 1991, 165:867-875.
40. Morales W.J., Angel J.D., O'Brien W.F., et al. A randomized study of antibiotic therapy in idiopathic preterm labor. Obstet Gynecol 1988, 72:829-833.
41. Winkler M., Baumann L., Ruchhäberle K.E., et al. Erythromycin therapy for subclinical intrauterine infections in threatened preterm delivery: a preliminary report. J Perinatal Med 1988, 16:253-256.
42. Norman K., Pattison R.C., de Souza J., et al. Ampicillin and metronidazole treatment in preterm labour: a multicentre, randomised controlled trial. Br J Obstet Gynecol 1994, 101:404-408.
43. Nadisauskiene R., Bergstrom S., Kilda A. Ampicillin in the treatment of preterm labor: a randomised, placebo-controlled study. Gynecol Obstet Invest 1996, 41:89-92.
44. Svare J., Langhoff-Roos J., Anderson L.F., et al. Ampicillin-metronidazole treatment in idiopathic preterm labour: a randomised controlled muticentre trial. Br J Obstet Gynecol 1997, 104:892-897.
45. Newton E.R., Dinsmoor M.J., Gibbs R.S. A randomized, blinded, placebo-controlled trial of antibiotics in idiopathic preterm labor. Obstet Gynecol 1989, 74:562-566.
46. Newton E.R., Shields L., Ridgway L.E., et al. Combination antibiotics and indomethacin in idiopathic preterm labor: a randomized double-blind clinical trial. Am J Obstet Gynecol 1991, 165:1753-1759.
47. McCaul J.F., Perry K.G., Moore J.L., et al. Adjunctive antibiotic treatment of women with preterm rupture of membranes or preterm labor. Int J Gynaecol Obstet 1992, 38:19-24.
48. Romero R., Sibai B.M., Caritis S., et al. Antibiotic treatment of preterm labor with intact membranes: a multicenter, randomized, double-blinding, placebo-controlled trial. Am J Obstet Gynecol 1993, 169:764-774.
49. Cox S.M., Bohman V.R., Sherman M.L., et al. Randomized investigation of antimicrobials for the prevention of preterm birth. Am J Obstet Gynecol 1996, 174:206-210.
50. Kenyon S.L., Taylor D.J., Tarnow-Mordi W. Broad-spectrum antibiotics for spontaneous preterm labour: the ORACLE II randomised trial. ORACLE Collaborative Group. Lancet 2001, 357:989-994. ORACLE Collaborative Group.
51. Kenyon S., Pike K., Jones D.R., et al. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 2008, 372:1319-1327.
52. King J., Flenady V. Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database Syst Rev 2002, (4). CD000246.
53. Hutzal C.E., Boyle E.M., Kenyon S.L., et al. Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis. Am J Obstet Gynecol 2008, 199:e1-e8. 620.
54. Tsoi E., Akmal S., Rane S., et al. Ultrasound assessment of cervical length in threatened preterm labor. Ultrasound Obstet Gynecol 2003, 21:552-555.
55. Fuchs I., Tsoi E., Henrich W., et al. Sonographic measurement of cervical length in twin pregnancies in threatened preterm labor. Ultrasound Obstet Gynecol 2004, 23:42-45.
56. Tsoi E., Akmal S., Geerts L., et al. Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor. Ultrasound Obstet Gynecol 2006, 27:368-372.
57. Schmitz T., Maillard F., Bessard-Bacquaert S., et al. Selective use of fetal fibronectin detection after cervical length measurement to predict spontaneous preterm delivery in women with preterm labor. Am J Obstet Gynecol 2006, 194:138-143.
58. Mercer B.M., Carr T.L., Beazley D.D., et al. Antibiotic use in pregnancy and drug-resistant infant sepsis. Am J Obstet Gynecol 1999, 181:816-821.
59. Terrone D.A., Rinehart B.K., Einstein M.H., et al. Neonatal sepsis and death caused by resistant Escherichia coli; Possible consequences of extended maternal ampicillin administration. Am J Obstet Gynecol 1999, 180:1345-1348.
60. Bizzarro M.J., Dembry L., Baltimore R.S., et al. Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics 2008, 121:689-696.