Deletion and down-regulation of HRH4 gene in gastric carcinomas: A potential correlation with tumor progression

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Zhang, Chao ^a   Xiong, Yi ^a   Li, Jiana ^a   Yang, Yang ^a   Liu, Li ^a   Wang, Wen ^a   Wang, Luo ^a   Li, Manhui ^a   Fang, Zhengyu ^a  

^a Biomedical Research Institute   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE; HISTAMINE RECEPTOR; HISTAMINE RECEPTOR H4; MESSENGER RNA; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; G PROTEIN COUPLED RECEPTOR; HRH4 PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DOWN REGULATION; EXPOSURE; GENE CONTROL; GENE DELETION; GENE DOSAGE; GENE EXPRESSION REGULATION; HRH4 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; ONCOGENE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; STOMACH CARCINOMA; TUMOR GROWTH; WESTERN BLOTTING; CASE CONTROL STUDY; CELL PROLIFERATION; COPY NUMBER VARIATION; DISEASE COURSE; DRUG EFFECT; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; METABOLISM; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE; TUMOR GENE;

CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA COPY NUMBER VARIATIONS; DOWN-REGULATION; GENE DELETION; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HISTAMINE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 84857401055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031207     Document Type: Article

References (33)

1. Blaya B, Nicolau-Galmes F, Jangi SM, Ortega-Martinez I, Alonso-Tejerina E, et al. (2010) Histamine and histamine receptor antagonists in cancer biology. Inflamm Allergy Drug Targets 9: 146-157.
2. Medina MA, Quesada AR, Nunez de Castro I, Sanchez-Jimenez F, (1999) Histamine, polyamines, and cancer. Biochem Pharmacol 57: 1341-1344.
3. Molnar EL, Cricco G, Martin G, Darvas Z, Hegyesi H, et al. (2001) Histamine as a potential autocrine regulator of melanoma. Inflamm Res 50 (Suppl 2): S102-103.
4. Malaviya R, Uckun FM, (2000) Histamine as an autocrine regulator of leukemic cell proliferation. Leuk Lymphoma 36: 367-373.
5. Nielsen HJ, Hammer JH, Moesgaard F, Kehlet H, (1991) Possible role of histamine-2 receptor antagonists for adjuvant treatment in colorectal cancer. Clinical review. Eur J Surg 157: 437-441.
6. Suonio E, Tuomisto L, Alhava E, (1994) Effects of histamine, H1, H2 and Hic receptor antagonists and alpha-fluoromethylhistidine on the growth of human colorectal cancer in the subrenal capsule assay. Agents Actions 41 Spec No: C118-120.
7. Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, et al. (2005) Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology 128: 1965-1983.
8. Burtin C, Scheinmann P, Salomon JC, Lespinats G, Canu P, (1982) Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors. Br J Cancer 45: 54-60.
9. Amland PF, Svane S, (1987) [H2 receptor antagonist treatment and stomach cancer]. Tidsskr Nor Laegeforen 107: 1023.
10. de Esch IJ, Thurmond RL, Jongejan A, Leurs R, (2005) The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sci 26: 462-469.
11. Thurmond RL, Gelfand EW, Dunford PJ, (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov 7: 41-53.
12. Petit-Bertron AF, Machavoine F, Defresne MP, Gillard M, Chatelain P, et al. (2009) H4 histamine receptors mediate cell cycle arrest in growth factor-induced murine and human hematopoietic progenitor cells. PLoS One 4: e6504.
13. Medina V, Croci M, Crescenti E, Mohamad N, Sanchez-Jimenez F, et al. (2008) The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment. Cancer Biol Ther 7: 28-35.
14. Cricco GP, Mohamad NA, Sambuco LA, Genre F, Croci M, et al. (2008) Histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. Inflamm Res 57 (Suppl 1): S23-24.
15. Sander LE, Lorentz A, Sellge G, Coeffier M, Neipp M, et al. (2006) Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 55: 498-504.
16. Boer K, Helinger E, Helinger A, Pocza P, Pos Z, et al. (2008) Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine. Eur J Cell Biol 87: 227-236.
17. Fang Z, Yao W, Xiong Y, Li J, Liu L, et al. (2011) Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression. BMC Cancer 11: 195.
18. Cianchi F, Cortesini C, Schiavone N, Perna F, Magnelli L, et al. (2005) The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin Cancer Res 11: 6807-6815.
19. Yamamoto S, Midorikawa Y, Morikawa T, Nishimura Y, Sakamoto H, et al. (2010) Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma. Genes Chromosomes Cancer 49: 487-496.
20. Lassmann S, Weis R, Makowiec F, Roth J, Danciu M, et al. (2007) Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. J Mol Med 85: 293-304.
21. Knosel T, Schluns K, Stein U, Schwabe H, Schlag PM, et al. (2003) Genetic imbalances with impact on survival in colorectal cancer patients. Histopathology 43: 323-331.
22. Sakakura C, Mori T, Sakabe T, Ariyama Y, Shinomiya T, et al. (1999) Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer 24: 299-305.
23. Fang Z, Xiong Y, Li J, Liu L, Li M, et al. (2011) Detection of APC gene deletions in colorectal malignancies using quantitative PCR in a Chinese population. Pathol Oncol Res 17: 657-661.
24. Yu B, Shao Y, Li P, Zhang J, Zhong Q, et al. (2010) Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br J Dermatol 163: 935-940.
25. Campanella GS, Tager AM, El Khoury JK, Thomas SY, Abrazinski TA, et al. (2008) Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A 105: 4814-4819.
26. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, et al. (2006) Global variation in copy number in the human genome. Nature 444: 444-454.
27. Backert S, Gressmann H, Kwok T, Zimny-Arndt U, Konig W, et al. (2005) Gene expression and protein profiling of AGS gastric epithelial cells upon infection with Helicobacter pylori. Proteomics 5: 3902-3918.
28. Bach S, Makristathis A, Rotter M, Hirschl AM, (2002) Gene expression profiling in AGS cells stimulated with Helicobacter pylori isogenic strains (cagA positive or cagA negative). Infect Immun 70: 988-992.
29. Speleman F, Kumps C, Buysse K, Poppe B, Menten B, et al. (2008) Copy number alterations and copy number variation in cancer: close encounters of the bad kind. Cytogenet Genome Res 123: 176-182.
30. Fukushima Y, (2004) [Functional analyses of gastric mucosa using mice deficient in both histamine H2 receptor and CCKB/gastrin receptor]. Nihon Rinsho 62: 551-555.
31. Ciacci C, Zarrilli R, Ricci V, De Luca A, Mazzacca G, et al. (1996) Histamine H2-receptor antagonists stimulate proliferation but not migration of human gastric mucosal cells in vitro. Dig Dis Sci 41: 972-978.
32. Burtin C, Noirot C, Scheinmann P, (1988) Antitumour activity of histamine plus H2-receptor antagonist. Lancet 2: 1369.
33. Sherr CJ, Roberts JM, (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512.