Synchronous clear cell renal cell carcinoma and tubulocystic carcinoma: Genetic evidence of independent ontogenesis and implications of chromosomal imbalances in tumor progression

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Quiroga Garza, Gabriela ^a   Piña Oviedo, Sergio ^a   Cuevas Ocampo, Karime ^c   Goldfarb, Richard ^a   Schwartz, Mary R ^a   Ayala, Alberto G ^a,b   Monzon, Federico A ^a,b,d  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Collecting duct carcinoma; Cystic tubules; Fuhrman nuclear grade; Genetic profile; Renal cell carcinoma; Synchronous tumor; Tubulocystic carcinoma; Tumor progression; Virtual karyotyping

Indexed keywords

AGED; ARTICLE; CASE REPORT; CYST; DISEASE COURSE; GENE DOSAGE; GENETICS; HUMAN; KARYOTYPING; KIDNEY CARCINOMA; KIDNEY TUMOR; MALE; MULTIPLE CANCER; PATHOLOGY;

AGED; CARCINOMA, RENAL CELL; CYSTS; DISEASE PROGRESSION; GENE DOSAGE; HUMANS; KARYOTYPING; KIDNEY NEOPLASMS; MALE; NEOPLASMS, MULTIPLE PRIMARY;

EID: 84857399131     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-21     Document Type: Article

References (28)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90. 10.3322/caac.20107, 21296855.
2. Siegel R, Naishadham D, Jemal A. Cancer Statistics 2012. CA Cancer J Clin 2012, 62(1):10-29. 10.3322/caac.20138, 22237781.
3. Kim HJ, Shen SS, Ayala AG, Ro JY, Truong LD, Alvarez K, Bridge JA, Gatalica Z, Hagenkord JM, Gonzalez-Berjon JM, Monzon FA. Virtual-karyotyping with SNP microarrays in morphologically challenging renal cell neoplasms: a practical and useful diagnostic modality. Am J Surg Pathol 2009, 33:1276-1286. 10.1097/PAS.0b013e3181a2aa36, 19461508.
4. World Health Organization Classification of Tumors. Pathology and genetics of tumors of the urinary system and male genital organs. 2004, Lyon: IARC Press, Eble JN, Sauter G, Epstein JI, Sesterhenn IA.
5. Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC. Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol 2009, 33:384-392. 10.1097/PAS.0b013e3181872d3f, 19011562.
6. Hagenkord JM, Gatalica Z, Jonasch E, Monzon FA. Clinical genomics of renal epithelial tumors. Cancer Genet 2011, 204:285-297. 10.1016/j.cancergen.2011.06.001, 21763625.
7. Azoulay S, Vieillefond A, Paraf F, Pasquier D, Cussenot O, Callard P, Sibony M. Tubulocystic carcinoma of the kidney: a new entity among renal tumors. Virchows Arch 2007, 451:905-909. 10.1007/s00428-007-0483-7, 17786473.
8. Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, Shah RB, Yang Y, Chuang ST, Lin F, et al. Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol 2008, 32:177-187. 10.1097/PAS.0b013e318150df1d, 18223319.
9. Masson P. Tumeurs humaines. Histologie, Diagnostics et techniques 1968, Paris: Librairie Maloine.
10. MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 1997, 50:679-684. 10.1016/S0090-4295(97)00335-X, 9372874.
11. Amin MB, MacLennan GT, Paraf F, et al. Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 29 cases of a distinctive rare subtype of renal carcinoma. Mod Pathol 2004, 17(suppl):137A.
12. Hora M, Urge T, Eret V, Stransky P, Klecka J, Kreuzberg B, Ferda J, Hyrsl L, Breza J, Holeckova P, et al. Tubulocystic renal carcinoma: a clinical perspective. World J Urol 2011, 29:349-54. 10.1007/s00345-010-0614-7, 21107846.
13. Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, Li R, Yang Y, Lin F, Elson P, et al. Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol 2009, 33:1840-1849. 10.1097/PAS.0b013e3181be22d1, 19898225.
14. Osunkoya AO, Young AN, Wang W, Netto GJ, Epstein JI. Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. Am J Surg Pathol 2009, 33:1103-1106. 10.1097/PAS.0b013e3181a13e7b, 19390420.
15. Radhakrishnan A, Maclennan GT, Hennigar RA, et al. Ultrastructural and immunohistochemical (IHC) appraisal of tubulocystic carcinoma (TCCa) of the kidney: histogenetic and diagnostic implications. Mod Pathol 2005, 18:160A.
16. Lane BR, Campbell SC, Remer EM, Fergany AF, Williams SB, Novick AC, Weight CJ, Magi-Galluzzi C, Zhou M. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology 2008, 71:1142-1148. 10.1016/j.urology.2007.11.106, 18313107.
17. Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, Oliva E. Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol 2007, 31:489-500. 10.1097/PAS.0b013e31802bdd56, 17414095.
18. Mohanty SK, Parwani AV. Mixed epithelial and stromal tumors of the kidney: an overview. Arch Pathol Lab Med 2009, 133:1483-1486.
19. Madewell JE, Goldman SM, Davis CJ, Hartman DS, Feigin DS, Lichtenstein JE. Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. Radiology 1983, 146:309-321.
20. Gonul II, Cakr A, Sozen S, Ataoglu O, Alkibay T. A case of tubulocystic carcinoma simultaneously occuring with clear cell type renal cell carcinoma and micropapillary urothelial carcinoma of bladder. South Med J 2009, 102:754-757. 10.1097/SMJ.0b013e3181a819c1, 19488016.
21. Brennan C, Srigley JR, Whelan C, Cooper J, Delahunt B. Type 2 and clear cell papillary renal cell carcinoma, and tubulocystic carcinoma: a unifying concept. Anticancer Res 2010, 30:641-644.
22. Deshmukh M, Shet T, Bakshi G, Desai S. Tubulocystic carcinoma of kidney associated with papillary renal cell carcinoma. Indian J Pathol Microbiol 2011, 54:127-130. 10.4103/0377-4929.77363, 21393894.
23. Brunelli M, Gobbo S, Cossu-Rocca P, Cheng L, Hes O, Delahunt B, Pea M, Bonetti F, Mina MM, Ficarra V, et al. Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma. Mod Pathol 2007, 20:303-309. 10.1038/modpathol.3800739, 17277768.
24. Patani N, Barbashina V, Lambros MB, Gauthier A, Mansour M, Mackay A, Reis-Filho JS. Direct evidence for concurrent morphological and genetic heterogeneity in an invasive ductal carcinoma of triple-negative phenotype. J Clin Pathol 2011, 64:822-828. 10.1136/jclinpath-2011-200135, 21676924.
25. Bacolod MD, Schemmann GS, Giardina SF, Paty P, Notterman DA, Barany F. Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. Cancer Res 2009, 69:723-727. 10.1158/0008-5472.CAN-08-3543, 19155292.
26. Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, Tannir N, Parwani AV, Jonasch E. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol 2011, 24:1470-1479. 10.1038/modpathol.2011.107, 21725288.
27. Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, de-Peralta Venturina M, Deshpande A, Menon M. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol 2002, 26:281-291. 10.1097/00000478-200203000-00001, 11859199.
28. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982, 6:655-663. 10.1097/00000478-198210000-00007, 7180965.