Androgen receptor coregulators: Recruitment via the coactivator binding groove

Molecular and Cellular Endocrinology

Volumn 352, Issue 1-2, 2012, Pages 57-69

  van de Wijngaart, Dennis J ^a   Dubbink, Hendrikus Jan ^a   van Royen, Martin E ^a   Trapman, Jan ^a   Jenster, Guido ^a  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

Androgen receptor; Coactivator; Corepressor; Mediator; Promoter; Transcription regulation

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR COREGULATOR; MEDIATOR COMPLEX; MUTANT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IIF; TRANSCRIPTION FACTOR IIH; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; COMPLEX FORMATION; HISTONE MODIFICATION; HORMONE RECEPTOR INTERACTION; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BLOCKING; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; DIHYDROTESTOSTERONE; HUMANS; MALE; PROTEIN BINDING; RECEPTORS, ANDROGEN; TESTOSTERONE;

EID: 84857368853     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.08.007     Document Type: Review

References (169)

1. Aarnisalo P., Palvimo J.J., Janne O.A. CREB-binding protein in androgen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 1998, 95:2122-2127.
2. Alen P., Claessens F., Verhoeven G., Rombauts W., Peeters B. The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription. Mol. Cell. Biol. 1999, 19:6085-6097.
3. Andersen R.J., Mawji N.R., Wang J., Wang G., Haile S., Myung J.K., Watt K., Tam T., Yang Y.C., Banuelos C.A., Williams D.E., McEwan I.J., Wang Y., Sadar M.D. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell. 2010, 17:535-546.
4. Aoyagi S., Archer T.K. Dynamics of coactivator recruitment and chromatin modifications during nuclear receptor mediated transcription. Mol. Cell. Endocrinol. 2008, 280:1-5.
5. Arnold L.A., Estebanez-Perpina E., Togashi M., Jouravel N., Shelat A., McReynolds A.C., Mar E., Nguyen P., Baxter J.D., Fletterick R.J., Webb P., Guy R.K. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J. Biol. Chem. 2005, 280:43048-43055.
6. Askew E.B., Bai S., Blackwelder A.J., Wilson E.M. Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J. Biol. Chem. 2010, 285:21824-21836.
7. Askew E.B., Gampe R.T., Stanley T.B., Faggart J.L., Wilson E.M. Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone. J. Biol. Chem. 2007, 282:25801-25816.
8. Bai S., He B., Wilson E.M. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. Mol. Cell. Biol. 2005, 25:1238-1257.
9. Becerril J., Hamilton A.D. Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides. Angew. Chem. Int. Ed. Engl. 2007, 46:4471-4473.
10. Berrevoets C.A., Doesburg P., Steketee K., Trapman J., Brinkmann A.O. Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). Mol. Endocrinol. 1998, 12:1172-1183.
11. Berrevoets C.A., Umar A., Trapman J., Brinkmann A.O. Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR). Biochem. J. 2004, 379:731-738.
12. Bevan C.L., Hoare S., Claessens F., Heery D.M., Parker M.G. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol. Cell. Biol. 1999, 19:8383-8392.
13. Bolton E.C., So A.Y., Chaivorapol C., Haqq C.M., Li H., Yamamoto K.R. Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 2007, 21:2005-2017.
14. Bourguet W., Germain P., Gronemeyer H. Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications. Trends Pharmacol. Sci. 2000, 21:381-388.
15. Brooke G.N., Parker M.G., Bevan C.L. Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression. Oncogene 2008, 27:2941-2950.
16. Bulynko Y.A., O'Malley B.W. Nuclear receptor coactivators: structural and functional biochemistry. Biochemistry 2011, 50:313-328.
17. Burd C.J., Morey L.M., Knudsen K.E. Androgen receptor corepressors and prostate cancer. Endocr. Relat. Cancer 2006, 13:979-994.
18. Callewaert L., Van Tilborgh N., Claessens F. Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res. 2006, 66:543-553.
19. Chamberlain N.L., Whitacre D.C., Miesfeld R.L. Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain. J. Biol. Chem. 1996, 271:26772-26778.
20. Chang C., Norris J.D., Gron H., Paige L.A., Hamilton P.T., Kenan D.J., Fowlkes D., McDonnell D.P. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. Mol. Cell. Biol. 1999, 19:8226-8239.
21. Chang C.Y., Abdo J., Hartney T., McDonnell D.P. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Mol. Endocrinol. 2005, 19:2478-2490.
22. Chang C.Y., McDonnell D.P. Evaluation of ligand-dependent changes in AR structure using peptide probes. Mol. Endocrinol. 2002, 16:647-660.
23. Chang C.Y., McDonnell D.P. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol. Sci. 2005, 26:225-228.
24. Chen H., Lin R.J., Schiltz R.L., Chakravarti D., Nash A., Nagy L., Privalsky M.L., Nakatani Y., Evans R.M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 1997, 90:569-580.
25. Cheng S., Brzostek S., Lee S.R., Hollenberg A.N., Balk S.P. Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol. Endocrinol. 2002, 16:1492-1501.
26. Claessens F., Denayer S., Van Tilborgh N., Kerkhofs S., Helsen C., Haelens A. Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl. Recept. Signal 2008, 6:e008.
27. Cohen R.N., Wondisford F.E., Hollenberg A.N. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol. Endocrinol. 1998, 12:1567-1581.
28. Coulthard V.H., Matsuda S., Heery D.M. An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220. J. Biol. Chem. 2003, 278:10942-10951.
29. Cui, J., Yang, Y., Zhang, C., Hu, P., Kan, W., Bai, X., Liu, X., Song, H., 2010. FBI-1 functions as a novel AR co-repressor in prostate cancer cells. Cell. Mol. Life Sci.
30. Dai Y., Ngo D., Forman L.W., Qin D.C., Jacob J., Faller D.V. Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol. Endocrinol. 2007, 21:1807-1821.
31. Darimont B.D. Finding specificity within a conserved interaction site. Chem. Biol. 2003, 10:675-676.
32. Darimont B.D., Wagner R.L., Apriletti J.W., Stallcup M.R., Kushner P.J., Baxter J.D., Fletterick R.J., Yamamoto K.R. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998, 12:3343-3356.
33. Denayer S., Helsen C., Thorrez L., Haelens A., Claessens F. The rules of DNA recognition by the androgen receptor. Mol. Endocrinol. 2010, 24:898-913.
34. DePrimo, S.E., Diehn, M., Nelson, J.B., Reiter, R.E., Matese, J., Fero, M., Tibshirani, R., Brown, P.O., Brooks, J.D., 2002. Transcriptional programs activated by exposure of human prostate cancer cells to androgen. Genome Biol. 3, RESEARCH0032.
35. Ding X.F., Anderson C.M., Ma H., Hong H., Uht R.M., Kushner P.J., Stallcup M.R. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities. Mol. Endocrinol. 1998, 12:302-313.
36. Domanskyi A., Virtanen K.T., Palvimo J.J., Janne O.A. Biochemical characterization of androgen receptor-interacting protein 4. Biochem. J. 2006, 393:789-795.
37. Dubbink H.J., Hersmus R., Pike A.C., Molier M., Brinkmann A.O., Jenster G., Trapman J. Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping. Mol. Endocrinol. 2006, 20:1742-1755.
38. Dubbink H.J., Hersmus R., Verma C.S., van der Korput H.A., Berrevoets C.A., van Tol J., Ziel-van der Made A.C., Brinkmann A.O., Pike A.C., Trapman J. Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor. Mol. Endocrinol. 2004, 18:2132-2150.
39. Eick, G.N., Thornton, J.W., 2010. Evolution of steroid receptors from an estrogen-sensitive ancestral receptor. Mol. Cell. Endocrinol, doi:10.1016/j.mce.2010.09.003.
40. Estebanez-Perpina E., Arnold L.A., Jouravel N., Togashi M., Blethrow J., Mar E., Nguyen P., Phillips K.J., Baxter J.D., Webb P., Guy R.K., Fletterick R.J. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol. Endocrinol. 2007, 21:2919-2928.
41. Estebanez-Perpina E., Moore J.M., Mar E., Delgado-Rodrigues E., Nguyen P., Baxter J.D., Buehrer B.M., Webb P., Fletterick R.J., Guy R.K. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J. Biol. Chem. 2005, 280:8060-8068.
42. Fan H.Y., He X., Kingston R.E., Narlikar G.J. Distinct strategies to make nucleosomal DNA accessible. Mol. Cell. 2003, 11:1311-1322.
43. Fu M., Liu M., Sauve A.A., Jiao X., Zhang X., Wu X., Powell M.J., Yang T., Gu W., Avantaggiati M.L., Pattabiraman N., Pestell T.G., Wang F., Quong A.A., Wang C., Pestell R.G. Hormonal control of androgen receptor function through SIRT1. Mol. Cell. Biol. 2006, 26:8122-8135.
44. Gaillard S., Dwyer M.A., McDonnell D.P. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Mol. Endocrinol. 2007, 21:62-76.
45. Gao W. Peptide antagonist of the androgen receptor. Curr. Pharm. Des. 2010, 16:1106-1113.
46. Gao W., Bohl C.E., Dalton J.T. Chemistry and structural biology of androgen receptor. Chem. Rev. 2005, 105:3352-3370.
47. Gaughan L., Brady M.E., Cook S., Neal D.E., Robson C.N. Tip60 is a co-activator specific for class I nuclear hormone receptors. J. Biol. Chem. 2001, 276:46841-46848.
48. Gaughan L., Logan I.R., Cook S., Neal D.E., Robson C.N. Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J. Biol. Chem. 2002, 277:25904-25913.
49. Gaughan L., Stockley J., Wang N., McCracken S.R., Treumann A., Armstrong K., Shaheen F., Watt K., McEwan I.J., Wang C., Pestell R.G., Robson C.N. Regulation of the androgen receptor by SET9-mediated methylation. Nucl. Acids Res. 2011, 39:1266-1279.
50. Germain P., Staels B., Dacquet C., Spedding M., Laudet V. Overview of nomenclature of nuclear receptors. Pharmacol. Rev. 2006, 58:685-704.
51. Gottlieb B., Beitel L.K., Wu J.H., Trifiro M. The androgen receptor gene mutations database (ARDB): 2004 update. Hum. Mutat. 2004, 23:527-533.
52. Greschik H., Moras D. Structure-activity relationship of nuclear receptor-ligand interactions. Curr. Top Med. Chem. 2003, 3:1573-1599.
53. Gronemeyer H., Laudet V. Transcription factors 3: nuclear receptors. Protein Profile 1995, 2:1173-1308.
54. Hall J.M., Chang C.Y., McDonnell D.P. Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Mol. Endocrinol. 2000, 14:2010-2023.
55. He B., Bai S., Hnat A.T., Kalman R.I., Minges J.T., Patterson C., Wilson E.M. An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP). J. Biol. Chem. 2004, 279:30643-30653.
56. He B., Bowen N.T., Minges J.T., Wilson E.M. Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 coactivator recruitment by activation function 2. J. Biol. Chem. 2001, 276:42293-42301.
57. He B., Gampe R.T., Kole A.J., Hnat A.T., Stanley T.B., An G., Stewart E.L., Kalman R.I., Minges J.T., Wilson E.M. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol. Cell. 2004, 16:425-438.
58. He B., Kemppainen J.A., Voegel J.J., Gronemeyer H., Wilson E.M. Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain. J. Biol. Chem. 1999, 274:37219-37225.
59. He B., Kemppainen J.A., Wilson E.M. FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. J. Biol. Chem. 2000, 275:22986-22994.
60. He B., Minges J.T., Lee L.W., Wilson E.M. The FXXLF motif mediates androgen receptor-specific interactions with coregulators. J. Biol. Chem. 2002, 277:10226-10235.
61. He B., Wilson E.M. Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Mol. Cell. Biol. 2003, 23:2135-2150.
62. Heemers H.V., Tindall D.J. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr. Rev. 2007, 28:778-808.
63. Heery D.M., Kalkhoven E., Hoare S., Parker M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997, 387:733-736.
64. Hendriksen P.J., Dits N.F., Kokame K., Veldhoven A., van Weerden W.M., Bangma C.H., Trapman J., Jenster G. Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res. 2006, 66:5012-5020.
65. Hodgson M.C., Astapova I., Cheng S., Lee L.J., Verhoeven M.C., Choi E., Balk S.P., Hollenberg A.N. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J. Biol. Chem. 2005, 280:6511-6519.
66. Hodgson M.C., Astapova I., Hollenberg A.N., Balk S.P. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res. 2007, 67:8388-8395.
67. Hong C.Y., Suh J.H., Kim K., Gong E.Y., Jeon S.H., Ko M., Seong R.H., Kwon H.B., Lee K. Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. Mol. Cell. Biol. 2005, 25:4841-4852.
68. Hsu C.L., Chen Y.L., Ting H.J., Lin W.J., Yang Z., Zhang Y., Wang L., Wu C.T., Chang H.C., Yeh S., Pimplikar S.W., Chang C. Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth. Mol. Endocrinol. 2005, 19:350-361.
69. Hsu C.L., Chen Y.L., Yeh S., Ting H.J., Hu Y.C., Lin H., Wang X., Chang C. The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs. J. Biol. Chem. 2003, 278:23691-23698.
70. Hu X., Lazar M.A. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 1999, 402:93-96.
71. Hu Y.C., Yeh S., Yeh S.D., Sampson E.R., Huang J., Li P., Hsu C.L., Ting H.J., Lin H.K., Wang L., Kim E., Ni J., Chang C. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J. Biol. Chem. 2004, 279:33438-33446.
72. Huang Z.Q., Li J., Sachs L.M., Cole P.A., Wong J. A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO J. 2003, 22:2146-2155.
73. Hur E., Pfaff S.J., Payne E.S., Gron H., Buehrer B.M., Fletterick R.J. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004, 2:E274.
74. Jenster G., Trapman J., Brinkmann A.O. Nuclear import of the human androgen receptor. Biochem. J. 1993, 293(Pt 3):761-768.
75. Jenster G., van der Korput H.A., Trapman J., Brinkmann A.O. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J. Biol. Chem. 1995, 270:7341-7346.
76. Jenster G., van der Korput J.A., Trapman J., Brinkmann A.O. Functional domains of the human androgen receptor. J. Steroid Biochem. Mol. Biol. 1992, 41:671-675.
77. Jeong B.C., Hong C.Y., Chattopadhyay S., Park J.H., Gong E.Y., Kim H.J., Chun S.Y., Lee K. Androgen receptor corepressor-19kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol. Endocrinol. 2004, 18:13-25.
78. Jouravel N., Sablin E., Arnold L.A., Guy R.K., Fletterick R.J. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr. D Biol. Crystallogr. 2007, 63:1198-1200.
79. Kang H.Y., Yeh S., Fujimoto N., Chang C. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J. Biol. Chem. 1999, 274:8570-8576.
80. Karvonen U., Janne O.A., Palvimo J.J. Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp. Cell. Res. 2006, 312:3165-3183.
81. Kazmin D., Prytkova T., Cook C.E., Wolfinger R., Chu T.M., Beratan D., Norris J.D., Chang C.Y., McDonnell D.P. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol. Endocrinol. 2006, 20:1201-1217.
82. Kinyamu H.K., Archer T.K. Modifying chromatin to permit steroid hormone receptor-dependent transcription. Biochim. Biophys. Acta 2004, 1677:30-45.
83. Klokk T.I., Kurys P., Elbi C., Nagaich A.K., Hendarwanto A., Slagsvold T., Chang C.Y., Hager G.L., Saatcioglu F. Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol. Cell. Biol. 2007, 27:1823-1843.
84. Ko L., Cardona G.R., Iwasaki T., Bramlett K.S., Burris T.P., Chin W.W. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol. Endocrinol. 2002, 16:128-140.
85. Ko S., Ahn J., Song C.S., Kim S., Knapczyk-Stwora K., Chatterjee B. Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol. Endocrinol. 2011, 25:433-444.
86. Kurebayashi S., Nakajima T., Kim S.C., Chang C.Y., McDonnell D.P., Renaud J.P., Jetten A.M. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem. Biophys. Res. Commun. 2004, 315:919-927.
87. Lavery D.N., McEwan I.J. The human androgen receptor AF1 transactivation domain: interactions with transcription factor IIF and molten-globule-like structural characteristics. Biochem. Soc. Trans. 2006, 34:1054-1057.
88. Le Douarin B., Nielsen A.L., Garnier J.M., Ichinose H., Jeanmougin F., Losson R., Chambon P. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996, 15:6701-6715.
89. Lee D.K., Duan H.O., Chang C. From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J. Biol. Chem. 2000, 275:9308-9313.
90. Lee D.K., Li M., Chang C. The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor. Biochem. Biophys. Res. Commun. 2003, 302:162-169.
91. Lee T.I., Young R.A. Transcription of eukaryotic protein-coding genes. Annu. Rev. Genet. 2000, 34:77-137.
92. Leers J., Treuter E., Gustafsson J.A. Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2. Mol. Cell. Biol. 1998, 18:6001-6013.
93. Lemon B., Inouye C., King D.S., Tjian R. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. Nature 2001, 414:924-928.
94. Li Y., Suino K., Daugherty J., Xu H.E. Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor. Mol. Cell. 2005, 19:367-380.
95. Liao G., Chen L.Y., Zhang A., Godavarthy A., Xia F., Ghosh J.C., Li H., Chen J.D. Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. J. Biol. Chem. 2003, 278:5052-5061.
96. Link K.A., Balasubramaniam S., Sharma A., Comstock C.E., Godoy-Tundidor S., Powers N., Cao K.H., Haelens A., Claessens F., Revelo M.P., Knudsen K.E. Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. Cancer Res. 2008, 68:4551-4558.
97. Link K.A., Burd C.J., Williams E., Marshall T., Rosson G., Henry E., Weissman B., Knudsen K.E. BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF. Mol. Cell. Biol. 2005, 25:2200-2215.
98. Malik S., Roeder R.G. The metazoan mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 2010, 11:761-772.
99. Markus S.M., Taneja S.S., Logan S.K., Li W., Ha S., Hittelman A.B., Rogatsky I., Garabedian M.J. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol. Biol. Cell. 2002, 13:670-682.
100. Marshall T.W., Link K.A., Petre-Draviam C.E., Knudsen K.E. Differential requirement of SWI/SNF for androgen receptor activity. J. Biol. Chem. 2003, 278:30605-30613.
101. Massie C.E., Adryan B., Barbosa-Morais N.L., Lynch A.G., Tran M.G., Neal D.E., Mills I.G. New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Rep. 2007, 8:871-878.
102. McEwan I.J., Gustafsson J. Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF. Proc. Natl. Acad. Sci. USA 1997, 94:8485-8490.
103. McEwan I.J., Lavery D., Fischer K., Watt K. Natural disordered sequences in the amino terminal domain of nuclear receptors: lessons from the androgen and glucocorticoid receptors. Nucl. Recept. Signal. 2007, 5:e001.
104. McInerney E.M., Rose D.W., Flynn S.E., Westin S., Mullen T.M., Krones A., Inostroza J., Torchia J., Nolte R.T., Assa-Munt N., Milburn M.V., Glass C.K., Rosenfeld M.G. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev. 1998, 12:3357-3368.
105. Metivier R., Reid G., Gannon F. Transcription in four dimensions: nuclear receptor-directed initiation of gene expression. EMBO Rep. 2006, 7:161-167.
106. Mettu N.B., Stanley T.B., Dwyer M.A., Jansen M.S., Allen J.E., Hall J.M., McDonnell D.P. The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Mol. Endocrinol. 2007, 21:2361-2377.
107. Metzger E., Wissmann M., Yin N., Muller J.M., Schneider R., Peters A.H., Gunther T., Buettner R., Schule R. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005, 437:436-439.
108. Naar A.M., Lemon B.D., Tjian R. Transcriptional coactivator complexes. Annu. Rev. Biochem. 2001, 70:475-501.
109. Nagy L., Kao H.Y., Love J.D., Li C., Banayo E., Gooch J.T., Krishna V., Chatterjee K., Evans R.M., Schwabe J.W. Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev. 1999, 13:3209-3216.
110. Need E.F., Scher H.I., Peters A.A., Moore N.L., Cheong A., Ryan C.J., Wittert G.A., Marshall V.R., Tilley W.D., Buchanan G. A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin. Endocrinology 2009, 150:2674-2682.
111. Needham M., Raines S., McPheat J., Stacey C., Ellston J., Hoare S., Parker M. Differential interaction of steroid hormone receptors with LXXLL motifs in SRC-1a depends on residues flanking the motif. J. Steroid. Biochem. Mol. Biol. 2000, 72:35-46.
112. Nie Z., Xue Y., Yang D., Zhou S., Deroo B.J., Archer T.K., Wang W. A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol. Cell. Biol. 2000, 20:8879-8888.
113. Niki T., Takahashi-Niki K., Taira T., Iguchi-Ariga S.M., Ariga H. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res. 2003, 1:247-261.
114. Nolte R.T., Wisely G.B., Westin S., Cobb J.E., Lambert M.H., Kurokawa R., Rosenfeld M.G., Willson T.M., Glass C.K., Milburn M.V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 1998, 395:137-143.
115. Northrop J.P., Nguyen D., Piplani S., Olivan S.E., Kwan S.T., Go N.F., Hart C.P., Schatz P.J. Selection of estrogen receptor beta- and thyroid hormone receptor beta-specific coactivator-mimetic peptides using recombinant peptide libraries. Mol. Endocrinol. 2000, 14:605-622.
116. Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Biochemistry 2007, 46:683-695.
117. Pathrose P., Barmina O., Chang C.Y., McDonnell D.P., Shevde N.K., Pike J.W. Inhibition of 1, 25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. J. Bone Miner. Res. 2002, 17:2196-2205.
118. Perissi V., Jepsen K., Glass C.K., Rosenfeld M.G. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 2010, 11:109-123.
119. Perissi V., Staszewski L.M., McInerney E.M., Kurokawa R., Krones A., Rose D.W., Lambert M.H., Milburn M.V., Glass C.K., Rosenfeld M.G. Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 1999, 13:3198-3208.
120. Phelan M.L., Sif S., Narlikar G.J., Kingston R.E. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol. Cell. 1999, 3:247-253.
121. Pike J.W., Pathrose P., Barmina O., Chang C.Y., McDonnell D.P., Yamamoto H., Shevde N.K. Synthetic LXXLL peptide antagonize 1, 25-dihydroxyvitamin D3-dependent transcription. J. Cell. Biochem. 2003, 88:252-258.
122. Powell S.M., Christiaens V., Voulgaraki D., Waxman J., Claessens F., Bevan C.L. Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate. Endocr. Relat. Cancer 2004, 11:117-130.
123. Quayle S.N., Mawji N.R., Wang J., Sadar M.D. Androgen receptor decoy molecules block the growth of prostate cancer. Proc. Natl. Acad. Sci. USA 2007, 104:1331-1336.
124. Reid J., Murray I., Watt K., Betney R., McEwan I.J. The androgen receptor interacts with multiple regions of the large subunit of general transcription factor TFIIF. J. Biol. Chem. 2002, 277:41247-41253.
125. Rosenfeld M.G., Lunyak V.V., Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 2006, 20:1405-1428.
126. Rouleau N., Domans'kyi A., Reeben M., Moilanen A.M., Havas K., Kang Z., Owen-Hughes T., Palvimo J.J., Janne O.A. Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell. 2002, 13:2106-2119.
127. Schaufele F., Carbonell X., Guerbadot M., Borngraeber S., Chapman M.S., Ma A.A., Miner J.N., Diamond M.I. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc. Natl. Acad. Sci. USA 2005, 102:9802-9807.
128. Shang Y., Myers M., Brown M. Formation of the androgen receptor transcription complex. Mol. Cell. 2002, 9:601-610.
129. Sharma M., Sun Z. 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. Mol. Endocrinol. 2001, 15:1918-1928.
130. Sharma M., Zarnegar M., Li X., Lim B., Sun Z. Androgen receptor interacts with a novel MYST protein, HBO1. J. Biol. Chem. 2000, 275:35200-35208.
131. Shen H.C., Coetzee G.A. The androgen receptor: unlocking the secrets of its unique transactivation domain. Vitam. Horm. 2005, 71:301-319.
132. Sheppard H.M., Harries J.C., Hussain S., Bevan C., Heery D.M. Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1. Mol. Cell. Biol. 2001, 21:39-50.
133. Shiau A.K., Barstad D., Loria P.M., Cheng L., Kushner P.J., Agard D.A., Greene G.L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 1998, 95:927-937.
134. Shiota M., Yokomizo A., Tada Y., Inokuchi J., Tatsugami K., Kuroiwa K., Uchiumi T., Fujimoto N., Seki N., Naito S. Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR. Mol. Endocrinol. 2010, 24:114-127.
135. Simental J.A., Sar M., Lane M.V., French F.S., Wilson E.M. Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. 1991, 266:510-518.
136. Smith C.L., O'Malley B.W. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 2004, 25:45-71.
137. Southwell J., Chowdhury S.F., Gottlieb B., Beitel L.K., Lumbroso R., Purisima E.O., Trifiro M. An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancer. J. Steroid. Biochem. Mol. Biol. 2008, 111:138-146.
138. Spencer T.E., Jenster G., Burcin M.M., Allis C.D., Zhou J., Mizzen C.A., McKenna N.J., Onate S.A., Tsai S.Y., Tsai M.J., O'Malley B.W. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 1997, 389:194-198.
139. Steketee K., Berrevoets C.A., Dubbink H.J., Doesburg P., Hersmus R., Brinkmann A.O., Trapman J. Amino acids 3-13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor. Eur. J. Biochem. 2002, 269:5780-5791.
140. Tan J.A., Hall S.H., Petrusz P., French F.S. Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. Endocrinology 2000, 141:3440-3450.
141. Thornton J.W., Kelley D.B. Evolution of the androgen receptor: structure-function implications. Bioessays 1998, 20:860-869.
142. Trapman J., Dubbink H.J. The role of cofactors in sex steroid action. Best Pract. Res. Clin. Endocrinol. Metab. 2007, 21:403-414.
143. Trotter K.W., Archer T.K. Nuclear receptors and chromatin remodeling machinery. Mol. Cell. Endocrinol. 2007, 265-266:162-167.
144. Trotter K.W., Archer T.K. The BRG1 transcriptional coregulator. Nucl. Recept. Signal. 2008, 6:e004.
145. van de Wijngaart D.J., Dubbink H.J., Molier M., de Vos C., Jenster G., Trapman J. Inhibition of androgen receptor functions by gelsolin FxxFF peptide delivered by transfection, cell-penetrating peptides, and lentiviral infection. Prostate 2011, 71:241-253.
146. van de Wijngaart D.J., Dubbink H.J., Molier M., de Vos C., Trapman J., Jenster G. Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. Mol. Endocrinol. 2009, 23:1776-1786.
147. van de Wijngaart D.J., Molier M., Lusher S.J., Hersmus R., Jenster G., Trapman J., Dubbink H.J. Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H. J. Biol. Chem. 2010, 285:5097-5105.
148. van de Wijngaart D.J., van Royen M.E., Hersmus R., Pike A.C., Houtsmuller A.B., Jenster G., Trapman J., Dubbink H.J. Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain. J. Biol. Chem. 2006, 281:19407-19416.
149. van Royen M.E., Cunha S.M., Brink M.C., Mattern K.A., Nigg A.L., Dubbink H.J., Verschure P.J., Trapman J., Houtsmuller A.B. Compartmentalization of androgen receptor protein-protein interactions in living cells. J. Cell. Biol. 2007, 177:63-72.
150. van Royen M.E., Zotter A., Ibrahim S.M., Geverts B., Houtsmuller A.B. Nuclear proteins: finding and binding target sites in chromatin. Chromosome Res. 2011, 19:83-98.
151. Verrijdt G., Haelens A., Claessens F. Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol. Genet. Metab. 2003, 78:175-185.
152. Vijayvargia R., May M.S., Fondell J.D. A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression. Cancer Res. 2007, 67:4034-4041.
153. Wang L., Hsu C.L., Chang C. Androgen receptor corepressors: an overview. Prostate 2005, 63:117-130.
154. Wang L., Hsu C.L., Ni J., Wang P.H., Yeh S., Keng P., Chang C. Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells. Mol. Cell. Biol. 2004, 24:2202-2213.
155. Wang Q., Carroll J.S., Brown M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol. Cell. 2005, 19:631-642.
156. Wang Q., Li W., Liu X.S., Carroll J.S., Janne O.A., Keeton E.K., Chinnaiyan A.M., Pienta K.J., Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol. Cell. 2007, 27:380-392.
157. Wang Q., Sharma D., Ren Y., Fondell J.D. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J. Biol. Chem. 2002, 277:42852-42858.
158. Wang W., Cote J., Xue Y., Zhou S., Khavari P.A., Biggar S.R., Muchardt C., Kalpana G.V., Goff S.P., Yaniv M., Workman J.L., Crabtree G.R. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996, 15:5370-5382.
159. Wang W., Xue Y., Zhou S., Kuo A., Cairns B.R., Crabtree G.R. Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996, 10:2117-2130.
160. Wang X., Yeh S., Wu G., Hsu C.L., Wang L., Chiang T., Yang Y., Guo Y., Chang C. Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. J. Biol. Chem. 2001, 276:40417-40423.
161. Warnmark A., Treuter E., Gustafsson J.A., Hubbard R.E., Brzozowski A.M., Pike A.C. Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J. Biol. Chem. 2002, 277:21862-21868.
162. Wissmann M., Yin N., Muller J.M., Greschik H., Fodor B.D., Jenuwein T., Vogler C., Schneider R., Gunther T., Buettner R., Metzger E., Schule R. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell. Biol. 2007, 9:347-353.
163. Yamane K., Toumazou C., Tsukada Y., Erdjument-Bromage H., Tempst P., Wong J., Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006, 125:483-495.
164. Yeh S., Chang C. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 1996, 93:5517-5521.
165. Yoon H.G., Wong J. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. Mol. Endocrinol. 2006, 20:1048-1060.
166. York B., O'Malley B.W. Steroid receptor coactivator (SRC) family: masters of systems biology. J. Biol. Chem. 2010, 285:38743-38750.
167. Zhou X.E., Suino-Powell K.M., Li J., He Y., Mackeigan J.P., Melcher K., Yong E.L., Xu H.E. Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor. J. Biol. Chem. 2010, 285:9161-9171.
168. Zhou Z.X., Lane M.V., Kemppainen J.A., French F.S., Wilson E.M. Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 1995, 9:208-218.
169. Zhu P., Baek S.H., Bourk E.M., Ohgi K.A., Garcia-Bassets I., Sanjo H., Akira S., Kotol P.F., Glass C.K., Rosenfeld M.G., Rose D.W. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 2006, 124:615-629.