When an aluminium adjuvant is not an aluminium adjuvant used in human vaccination programmes

Vaccine

Volumn 30, Issue 12, 2012, Pages 2042-

  Exley, Christopher ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; ALUMINUM DERIVATIVE; ALUMINUM HYDROXIDE; ALUMINUM POTASSIUM SULFATE; AMORPHOUS ALUMINIUM HYDROXYPHOSPHATE; CRYSTALLINE ALUMINIUM OXYHYDROXIDE; DNA VACCINE; IMMUNOLOGICAL ADJUVANT; UNCLASSIFIED DRUG;

BIOLOGICAL ACTIVITY; CYTOTOXICITY; DRUG POTENTIATION; HUMAN; IMMUNE RESPONSE; IMMUNOREACTIVITY; INJECTION SITE REACTION; LETTER; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM; HUMANS; VACCINATION; VACCINES;

EID: 84857364035     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.10.042     Document Type: Letter

References (8)

1. Exley C., Siesjö P., Eriksson H. The immunobiology of aluminium adjuvants: how do they really work?. Trends Immunol 2010, 31:103-109.
2. Hem S.L., HogenEsch H. Relationship between physical and chemical properties of aluminium-containing adjuvants and immunopotentiation. Expert Rev Vaccines 2007, 6:685-698.
3. Marical T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K et al. DNA released from dying host cells mediates aluminium adjuvant activity. Nat Med. doi:10.1038/nm.2403.
4. Hem S.L., Johnston C.T., HogenEsch H. Imject Alum is not aluminium hydroxide adjuvant or aluminium phosphate adjuvant. Vaccine 2007, 25:4985-4986.
5. Exley C. Darwin, natural selection and the biological essentiality of aluminium and silicon. Trends Biochem Sci 2009, 34:589-593.
6. 2+ revealed by human T-cell immunodeficiency. Nature 2011, 475:471-476.
7. Exley C., Birchall J.D. The cellular toxicity of aluminium. J Theor Biol 1992, 159:83-98.
8. Weeratna R.D., McCluskie M.J., Xu Y., Davis H.L. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 2000, 18:1755-1762.