An epigenomic mechanism in retinoblastoma: The end of the story?

Genome Medicine

Volumn 4, Issue 2, 2012, Pages

  Murphree, A Linn ^a   Triche, Timothy J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCL 6 CO REPRESSOR PROTEIN; PROTEIN KINASE SYK; RB1 PROTEIN; REPRESSOR PROTEIN; RETINOBLASTOMA PROTEIN; SOMATOMEDIN B; UNCLASSIFIED DRUG;

CANCER GROWTH; CANCER RISK; DNA METHYLATION; EPIGENETICS; GENE MUTATION; GENE REPRESSION; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HUMAN; HYPOXIA; NOTE; OPTIC NERVE; PRIORITY JOURNAL; RETINOBLASTOMA; TUMOR VASCULARIZATION;

EID: 84857326656     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm314     Document Type: Note

References (10)

1. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986, 323:643-646. 10.1038/323643a0, 2877398.
2. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, et al. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 2012, 481:329-334.
3. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer 2004, 4:177-183. 10.1038/nrc1299, 2665285, 14993899.
4. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999, 96:8681-8686. 10.1073/pnas.96.15.8681, 17576, 10411935.
5. Galm O, Wilop S, Lüders C, Jost E, Gehbauer G, Herman JG, Osieka R. Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. Ann Hematol 2005, 84(Suppl 1):39-46.
6. Reik W, Brown KW, Slatter RE, Sartori P, Elliott M, Maher ER. Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome. Hum Mol Genet 1994, 3:1297-1301. 10.1093/hmg/3.8.1297, 7987305.
7. Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K, . Cancer Genome Atlas Research Network Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010, 17:510-522. 10.1016/j.ccr.2010.03.017, 2872684, 20399149, Cancer Genome Atlas Research Network.
8. Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. New Engl JMed 2009, 361:1058-1066.
9. Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol 2009, 11:1002-1009. 10.1038/ncb1913, 2752141, 19578371.
10. Kapranov P, St Laurent G, Raz T, Ozsolak F, Reynolds CP, Sorensen PH, Reaman G, Milos P, Arceci RJ, Thompson JF, Triche TJ. The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol 2011, 9:86. 10.1186/1741-7007-9-86, 3264510, 22185220.