Bakuchiol derivatives as novel and potent cytotoxic agents: A report

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 55-67

  Majeed, Rabiya ^a   Reddy, Mallepally V ^a   Chinthakindi, Praveen K ^a   Sangwan, Payare L ^a   Hamid, Abid ^a   Chashoo, Gousia ^a   Saxena, Ajit K ^a   Koul, Surrinder ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Apoptosis; Bakuchiol analogs; Cell cycle analysis; Heck coupling; Mercuration demercuration

Indexed keywords

1 METHOXY 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)BENZENE; 1 METHOXY [4 [3 (4 METHOXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]]BENZENE; 12,13 EPOXYBAKUCHIOL; 2,6 DIBROMO 4 (3 ETHYL 3,7 DIMETHYLOCTYL)PHENOL; 3 AMINO,4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENOL; 3 NITRO,4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENOL; 4 (3 ETHYL 3,7 DIMETHYLOCTYL) 2 IODOPHENOL; 4 (3 ETHYL 3,7 DIMETHYLOCTYL)PHENOL; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYL DECANOATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYL OCTANOATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYL PALMITATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYLACETATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYLBUTYRATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYLHEXANOATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYLPENTANOATE; 4 (3,7 DIMETHYL 3 VINYLOCTA 1,6 DIENYL)PHENYLPROPANOATE; 4 [ 3 (3 CHLORO 4 PROPOXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [2 [4 (2 HYDROXYPROPAN 2 YL) 1,2 DIMETHYLCYCLOPENTYL]VINYL]PHENOL; 4 [3 (2 METHOXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 (3 FORMYL,4 METHOXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 (4 AMINOSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 (4 FLUOROSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 (4 HYDROXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 (4 METHOXYSTYRYL) 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 4 [3 [3 (HYDROXYMETHYL) 4 METHOXYSTYRYL] 3,7 DIMETHYLOCTA 1,6 DIENYL]PHENOL; 6 (4 HYDROXYSTYRYL) 2,6 DIMETHYLOCTA 2,7 DIENAL; BAKUCHIOL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE; NEUROBLASTOMA CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; HUMANS; NEOPLASMS; PHENOLS; PSORALEA;

EID: 84857239458     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.018     Document Type: Article

References (21)

1. A. Chevalier, and D. Kindersley The Encyclopedia of Medicinal Plants 1996 9-780751-303148 London
2. J.A. Duke, and E.S. Ayensu Medicinal Plants of China Inc. 1985 0-917256-20-4
3. N.J. Sun, S.H. Woo, J.M. Cassady, and R.M. Snapka J. Nat. Prod. 61 1998 362 366
4. M.V. Reddy, N. Thota, P.L. Sangwan, P. Malhotra, F. Ali, I.A. Khan, S.S. Chimni, and S. Koul Eur. J. Med. Chem. 145 7 2010 3125 3134
5. J.B. Jaing, D.P. Thesson, B.A. Dusak, D.L. Dexter, G.J. Kang, and E. Hamel J. Med. Chem. 33 1990 1721 1728
6. F. Zouhiri, M. Danet, C. Benard, M. Normad-Boyle, G. Mbemba, J. d'Angelo, and D. Desmaele Tetrahedron Lett. 6 13 2005 2201 2205
7. J. Rocha-Periera, R. Cunha, D.C.G. Pinto, A.M.S. Silva, and M.S.J. Nascimento Bioorg. Med. Chem. 18 12 2010 4195 4201
8. I.K. Lee, M.S. Han, M.S. Lee, Y.S. Kim, and B.S. Yun Bioorg. Med. Chem. Lett. 20 18 2010 5459 5461
9. K. Bapat, G.J. Chintalwar, U. Pandey, V.S. Thakur, H.D. Sarma, S. Chattopadhyay, M.R.A. Pillia, and M. Venkatesh Appl. Radiat. Isot. 62 2005 389
10. H.L. Chen, H.G. Feng, and Y.C. Li Yao Xue Xue Bao 45 4 2010 467 470
11. Jui-Yi Chen, S.-Yu Lai, S.-Lin Pan, G. Mei Jow, J.-Wang Chern, and J.-Hwa Guh Biochem. Pharmacol. 66 2003 105 124
12. V.R. Pallela, M.R. Mallireddagarie, S.C. Bell, S.C. Cosenza, E.P. Reddy, M.V.R. Reddy, 228th ACS National Meeting, Philadelphia, USA, 2004.
13. H.V.K. Wangun, and C. Hertweck Eur. J. Org. Chem. 2007 3292 3295
14. J.J. Baldwin, W.B. Abrams, I.W. Wainer, D.E. Drayer, and M. Dekker Analytical Methods and Pharmacology New York, pp. 311-356 1988
15. D.E. Fisher Cell 78 1994 539 542
16. G.R. Mehta, U.R. Nayak, and S. Dev Tetrahedron Lett. 1966 4561 4567
17. S. Kaur, S. Kamboj, J. Singh, A.K. Saxena, and V.A. Dhuna Biotechnol. Lett. 27 2005 1815 1820
18. S. Bhushan, J.M. Rao, J. Singh, A.K. Saxena, and G.N. Qazi Nitric oxide 14 2006 72 88
19. O.S. Frankfurt, and A. Krishnan Anti Cancer Drugs 14 2003 555 561
20. Z. Yu, and W. Li Cancer Letts 238 2006 53 60
21. S. Desagher, S. Osen, A. Nicholas, R. Eskes, S. Montessuit, S. Lauper, K. Maundrell, B. Antonsson, and J.C. Hartinsu J. Cell Biol. 144 1999 891 901