Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis

Leukemia Research

Volumn 36, Issue 4, 2012, Pages 467-473

  Koren Michowitz, Maya ^a,c   Sato Otsubo, Aiko ^b   Nagler, Arnon ^c   Haferlach, Torsten ^d   Ogawa, Seishi ^b   Koeffler, H Phillip ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c SHEBA MEDICAL CENTER   (Israel)

^d MLL MUNICH LEUKEMIA LABORATORY   (Germany)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AML; Normal karyotype; Old age; SNP array

Indexed keywords

ANTINEOPLASTIC AGENT; GENOMIC DNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HUMAN; KARYOTYPE; MALE; MICROARRAY ANALYSIS; MUTATION RATE; PRIORITY JOURNAL; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT;

ADULT; AGE FACTORS; AGED; HUMANS; KAPLAN-MEIER ESTIMATE; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; LOSS OF HETEROZYGOSITY; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; YOUNG ADULT;

EID: 84857232746     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.10.013     Document Type: Article

References (16)

1. Juliusson G., Antunovic P., Derolf A., Lehmann S., Mollgard L., Stockelberg D., et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 2009, 113:4179-4187.
2. Appelbaum F.R., Gundacker H., Head D.R., Slovak M.L., Willman C.L., Godwin J.E., et al. Age and acute myeloid leukemia. Blood 2006, 107:3481-3485.
3. Büchner T., Berdel W.E., Haferlach C., Haferlach T., Schnittger S., Müller-Tidow C., et al. Age related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German acute myeloid leukemia cooperative group. J. Clin. Oncol. 2009, 27:61-69.
4. Mrozek K., Marcucci G., Paschka P., Whitman S.P., Bloomfield C.D. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 2007, 109:431-448.
5. Grimwade D. The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia. Best Pract. Res. Clin. Haematol. 2001, 14:497-529.
6. Bullinger L., Kronke J., Schon C., Radtke I., Urlbauer K., Botzenhardt U., et al. Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis. Leukemia 2009, 24:438-449.
7. Nannya Y.S.M., Nakazaki K., Hosoya N., Wang L., Hangaishi A., Kurokawa M., et al. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res. 2005, 65:6071-6079.
8. Yamamoto G.N.Y., Kato M., Sanada M., Levine R.L., Kawamata N., Hangaishi A., et al. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am. J. Hum. Genet. 2007, 81:114-126.
9. Weksberg R.H.S., Moldovan L., Bassett A.S., Chow E.W., Squire J.A. A method for accurate detection of genomic microdeletions using real-time quantitative PCR. BMC Genomics 2005, 6:180-190.
10. Kawamata N., Ogawa S., Zimmermann M., Kato M., Sanada M., Hemminki K., et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008, 111:776-784.
11. Sallmyr A., Fan J., Rassool F.V. Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair. Cancer Lett. 2008, 270:1-9.
12. Thorsten Klampfl A.H., Berg T., Gisslinger B., Francesco Passamonti M.D., Rumi E., Pietra D., et al. Chromosomal Aberration Network In Myeloproliferative Neoplasms. ASH Ann. Meeting Abs. 2010, 116:145.
13. Walter M.J., Payton J.E., Ries R.E., Shannon W.D., Deshmukh H., Zhao Y., et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc. Natl. Acad. Sci. 2009, 106:12950-12955.
14. Gorletta T.A., Gasparini P., D'Elios M.M., Trubia M., Pelicci P.G., Di Fiore P.P. Frequent loss of heterozygosity without loss of genetic material in acute myeloid leukemia with a normal karyotype genes. Chromosomes Cancer 2005, 44:334-337.
15. Akagi T., Ogawa S., Dugas M., Kawamata N., Yamamoto G., Nannya Y., et al. Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. Haematologica 2009, 94:213-223.
16. Parkin B., Erba H., Ouillette P., Roulston D., Purkayastha A., Karp J., et al. Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. Blood 2010, 16:4958-4967.