SNARE-wedging polyphenols as small molecular botox

Planta Medica

Volumn 78, Issue 3, 2012, Pages 233-236

  Yang, Yoosoo ^a   Choi, Jin Kyu ^b   Jung, Chang Hwa ^c   Koh, Hyun Ju ^b   Heo, Paul ^a   Shin, Jae Yoon ^a   Kim, Sehyun ^a   Park, Won Seok ^b   Shin, Hong Ju ^b   Kweon, Dae Hyuk ^a  

^a Sungkyunkwan University   (South Korea)

^b Amorepacific RandD Center   (South Korea)

^c Korea Food Research Institute   (South Korea)

Author keywords

acetylcholine; muscle paralysis; myricetin; small molecule polyphenol; SNARE

Indexed keywords

ACETYLCHOLINE; BOTULINUM TOXIN A; DELPHINIDIN; MEDITOXIN; MYRICETIN; NEUROTOXIN; POLYPHENOL; SNARE PROTEIN; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; CLOSTRIDIUM BOTULINUM; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; MOUSE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PARALYSIS; RISK ASSESSMENT;

ANIMALS; ANTHOCYANINS; BOTULINUM TOXINS, TYPE A; COSMETICS; FEMALE; FLAVONOIDS; HUMANS; MICE; NEUROMUSCULAR BLOCKING AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; POLYPHENOLS; SNARE PROTEINS;

CLOSTRIDIUM BOTULINUM; MUS;

EID: 84857232339     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280385     Document Type: Article

References (15)

1. Sollner T, Whiteheart S W., Brunner M, Erdjument-Bromage H, Geromanos S, Tempst P, Rothman J E. SNAP receptors implicated in vesicle targeting and fusion. Nature 1993 362 318-324 (Pubitemid 23101303)
2. Weber T, Zemelman B V., McNew J A., Westermann B, Gmachl M, Parlati F, Sollner T H., Rothman J E. SNARE pins: minimal machinery for membrane fusion. Cell 1998 92 759-772 (Pubitemid 28155315)
3. Sutton R B., Fasshauer D, Jahn R, Brunger A T. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature 1998 395 347-353 (Pubitemid 28450677)
4. Poirier M A., Xiao W, Macosko J C., Chan C, Shin Y K., Bennett M K. The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat Struct Biol 1998 5 765-769 (Pubitemid 28402077)
5. Hanson P I., Roth R, Morisaki H, Jahn R, Heuser J E. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell 1997 90 523-535 (Pubitemid 27347242)
6. Lin R C., Scheller R H. Structural organization of the synaptic exocytosis core complex. Neuron 1997 19 1087-1094 (Pubitemid 27512368)
7. Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Mol Microbiol 1994 13 1-8 (Pubitemid 24220537)
8. Jung C H., Yang Y S., Kim J S., Shin J I., Jin Y S., Shin J Y., Lee J H., Chung K M., Hwang J S., Oh J M., Shin Y K., Kweon D H. A search for synthetic peptides that inhibit soluble N-ethylmaleimide sensitive-factor attachment receptor-mediated membrane fusion. FEBS J 2008 275 3051-3063 (Pubitemid 351743580)
9. Jung C H., Yang Y S., Kim J S., Shin Y K., Hwang J S., Son E D., Lee H H., Chung K M., Oh J M., Lee J H., Kweon D H. Inhibition of SNARE-driven neuroexocytosis by plant extracts. Biotechnol Lett 2009 31 361-369
10. Yang Y, Shin J Y., Oh J M., Jung C H., Hwang Y, Kim S, Kim J S., Yoon K J., Ryu J Y., Shin J, Hwang J S., Yoon T Y., Shin Y K., Kweon D H. Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. Proc Natl Acad Sci USA 2010 107 22145-22150
11. Ray P, Berman J D., Middleton W, Brendle J. Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC12 cells. J Biol Chem 1993 268 11057-11064 (Pubitemid 23162292)
12. Hay D W., Wadsworth R M. The effects of calcium channel inhibitors and other procedures affecting calcium translocation on drug-induced rhythmic contractions in the rat vas deferens. Br J Pharmacol 1983 79 347-362 (Pubitemid 13055402)
13. Richardson C M., Dowdall M J., Bowman D. Inhibition of acetylcholine release from presynaptic terminals of skate electric organ by calcium channel antagonists: a detailed pharmacological study. Neuropharmacology 1996 35 1537-1546 (Pubitemid 27026483)
14. Aoki K R. A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice. Toxicon 2001 39 1815-1820 (Pubitemid 32971819)
15. Sugiyama H, Brenner S L., Dasgupta B R. Detection of Clostridium botulinum toxin by local paralysis elicited with intramuscular challenge. Appl Microbiol 1975 30 420-423