Discovery of GABAreceptor modulator aristolactone in a commercial sample of the chinese herbal drug chaihu (bupleurum chinense roots) unravels adulteration by nephrotoxic aristolochia manshuriensis roots

Planta Medica

Volumn 78, Issue 3, 2012, Pages 207-210

  Rueda, Diana C ^a   Zaugg, Janine ^a   Quitschau, Melanie ^a   Reich, Eike ^b   Hering, Steffen ^c   Hamburger, Matthias ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b CAMAG Laboratory   (Switzerland)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

adulteration; Apiaceae; aristolactone; Aristolochia sp.; Aristolochiaceae; aristolochic acids; Bupleurum chinense; traditional Chinese medicine

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ARISTOLOCHIA MANSHURIENSIS EXTRACT; BUPLEURUM CHINENSE EXTRACT; GERMACRANOLIDE ARISTOLACTONE; GERMACRANOLIDE DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG; ARISTOLOCHIC ACID; BUPLEURUM ROOT EXTRACT; HERBACEOUS AGENT;

ARISTOLOCHIA; ARTICLE; BUPLEURUM CHINENSE; DRUG ACTIVITY; DRUG QUALITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; NEPHROTOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; TANDEM MASS SPECTROMETRY; VOLTAGE CLAMP; XENOPUS LAEVIS; ANIMAL; BUPLEURUM; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG CONTAMINATION; DRUG EFFECT; HUMAN; KIDNEY DISEASE; MEDICINAL PLANT; METABOLISM; OOCYTE; TOXICITY TESTING; XENOPUS;

APIACEAE; ARISTOLOCHIA; ARISTOLOCHIA MANSHURIENSIS; ARISTOLOCHIACEAE; BUPLEURUM CHINENSE; XENOPUS LAEVIS;

ANIMALS; ARISTOLOCHIA; ARISTOLOCHIC ACIDS; BUPLEURUM; DRUG CONTAMINATION; DRUGS, CHINESE HERBAL; HUMANS; KIDNEY DISEASES; OOCYTES; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; RECEPTORS, GABA-A; TOXICITY TESTS; XENOPUS;

EID: 84857231995     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298171     Document Type: Article

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