Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

Prion

Volumn 6, Issue 1, 2012, Pages 62-72

  Poli, Giorgio ^a   Corda, Erica ^a   Lucchini, Barbara ^a   Puricelli, Maria ^a   Martino, Piera Anna ^a   Dall'Ara, Paola ^a   Villetti, Gino ^b   Bareggi, Silvio R ^c   Corona, Cristiano ^d   Costassa, Elena Vallino ^d   Gazzuola, Paola ^d   Iulini, Barbara ^d   Mazza, Maria ^d   Acutis, Pierluigi ^d   Mantegazza, Paolo ^c   Casalone, Cristina ^d   Imbimbo, Bruno P ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b CHIESI FARMACEUTICI S P A   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d DIF   (France)

Author keywords

secretase modulator; Murine model; Prion; Therapy; TSE

Indexed keywords

ANTIINFECTIVE AGENT; CHF 5074; CHF5074; GAMMA SECRETASE; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROPROTECTIVE AGENT; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INFECTION; CEREBELLUM; CONTROLLED STUDY; DIET; DISEASE MODEL; FEMALE; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PARIETAL CORTEX; PATHOLOGY; PRION; SCRAPIE; SURVIVAL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; BRAIN; CYCLOPROPANES; DISEASE MODELS, ANIMAL; FEMALE; FLURBIPROFEN; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; MICE; PRPSC PROTEINS; SCRAPIE; SURVIVAL ANALYSIS;

EID: 84857219969     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.6.1.18317     Document Type: Article

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