-
1
-
-
77955609431
-
Pharmacology target reduction and drug accumulation after oral feeding of an LNA antisense oligonucleotide directed against apoB-100
-
San Francisco CA USA April
-
Hardee GE, Lindholm MW, Hansen HF et al. Pharmacology, target reduction and drug accumulation after oral feeding of an LNA antisense oligonucleotide directed against apoB-100. Presented at: Arteriosclerosis, Thrombosis and Vascular Biology. San Francisco, CA, USA, April 2010.
-
(2010)
Presented At: Arteriosclerosis Thrombosis and Vascular Biology
-
-
Hardee, G.E.1
Lindholm, M.W.2
Hansen, H.F.3
-
2
-
-
65949106130
-
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
-
Aouadi M, Tesz GJ, Nicoloro SM et al. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458, 1180-1185 (2009).
-
(2009)
Nature.
, vol.458
, pp. 1180-1185
-
-
Aouadi, M.1
Tesz, G.J.2
Nicoloro, S.M.3
-
3
-
-
17144374243
-
-
Marcel Decker Inc. NY USA
-
Bennett FC, Swayze E, Geary RS et al. Antisense Oligonucleotide-Based Therapeutics, Gene and Cell Therapy (Second Edition). Marcel Decker Inc., NY, USA, 347-374 (2004).
-
(2004)
Antisense Oligonucleotide-Based Therapeutics Gene and Cell Therapy Second Edition
, pp. 347-374
-
-
Bennett, F.C.1
Swayze, E.2
Geary, R.S.3
-
4
-
-
84872469488
-
Routes and formulations for delivery of antisense oligonucleotides
-
Stanley TCEd CRC Press Taylor Francis Group UK
-
Hardee GE, Tillman LG, Geary RS. Routes and formulations for delivery of antisense oligonucleotides. Stanley TC(Ed). Antisense Drug Technology, Chapter 8. CRC Press, Taylor Francis Group, UK, 217-236 (2006).
-
(2006)
. Antisense Drug Technology Chapter
, vol.8
, pp. 217-236
-
-
Hardee, G.E.1
Tillman, L.G.2
Geary, R.S.3
-
5
-
-
38349171887
-
Oral delivery of antisense oligonucleotides: Plasma bioavailability of ISIS 104838 in man
-
Tillman L, Geary R, Hardee GE. Oral delivery of antisense oligonucleotides: plasma bioavailability of ISIS 104838 in man. J. Pharm. Sci. 97(1), 225-236 (2008).
-
(2008)
J. Pharm. Sci.
, vol.97
, Issue.1
, pp. 225-236
-
-
Tillman, L.1
Geary, R.2
Hardee, G.E.3
-
6
-
-
19444375104
-
DNA-based therapeutics and DNA delivery systems: A comprehensive review
-
DOI 10.1208/aapsj070109, 9
-
Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. J. Am. Pharm. Sci. 7(1), E61-E77 (2005). (Pubitemid 41554297)
-
(2005)
AAPS Journal
, vol.7
, Issue.1
-
-
Patil, S.D.1
Rhodes, D.G.2
Burgess, D.J.3
-
7
-
-
0032850519
-
Physiological mechanism for enhancement of paracellular drug transport
-
DOI 10.1016/S0168-3659(99)00031-0, PII S0168365999000310
-
Hayashi M, Sakai T, Hasegawa Y et al. Physiological mechanism for enhancement of paracellular drug transport. J. Control. Release Soc. 62, 141-148 (1999). (Pubitemid 29486492)
-
(1999)
Journal of Controlled Release
, vol.62
, Issue.1-2
, pp. 141-148
-
-
Hayashi, M.1
Sakai, T.2
Hasegawa, Y.3
Nishikawahara, T.4
Tomioka, H.5
Iida, A.6
Shimizu, N.7
Tomita, M.8
Awazu, S.9
-
8
-
-
0035119622
-
Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats
-
Geary RS, Khatsenko O, Bunker K et al. Absolute bioavailability of 2-O-(2- methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats. J. Pharmacol. Exp. Ther. 296(3), 898-904 (2001). (Pubitemid 32187363)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.296
, Issue.3
, pp. 898-904
-
-
Geary, R.S.1
Khatsenko, O.2
Bunker, K.3
Crooke, R.4
Moore, M.5
Burckin, T.6
Truong, L.7
Sasmor, H.8
Levin, A.A.9
-
9
-
-
0031950147
-
Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes
-
DOI 10.1023/A:1011934011690
-
Nicklin PL, Bayley D, Giddings J et al. Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes. Pharm. Res. 15(4), 583-591 (1998). (Pubitemid 28214952)
-
(1998)
Pharmaceutical Research
, vol.15
, Issue.4
, pp. 583-591
-
-
Nicklin, P.L.1
Bayley, D.2
Giddings, J.3
Craig, S.J.4
Cummins, L.L.5
Hastewell, J.G.6
Phillips, J.A.7
-
10
-
-
33646492929
-
Tight junction modulation and its relationship to drug delivery
-
Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv. Drug Deliv. Rev. 58, 15-28 (2006)
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 15-28
-
-
Salama, N.N.1
Eddington, N.D.2
Fasano, A.3
-
11
-
-
71549130146
-
Safety and efficacy of sodium caprate in promoting drug absorption: From in vitro to the clinic
-
Maher S, Leonard TW, Jacobsen J et al. Safety and efficacy of sodium caprate in promoting drug absorption: from in vitro to the clinic. Adv. Drug Deliv. Rev. 61, 1427-1449 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 1427-1449
-
-
Maher, S.1
Leonard, T.W.2
Jacobsen, J.3
-
12
-
-
38349178006
-
Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer
-
Tsutsumi K, Li SK, Hymas RV et al. Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer. J. Pharm. Sci. 97(1), 350-367 (2008).
-
(2008)
J. Pharm. Sci.
, vol.97
, Issue.1
, pp. 350-367
-
-
Tsutsumi, K.1
Li, S.K.2
Hymas, R.V.3
-
13
-
-
2642556483
-
Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate
-
DOI 10.1002/jps.20051
-
Raoof AA, Chiu P, Ramtoola, Z et al. Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate. J. Pharm. Sci. 93(6), 1431-1439 (2004). (Pubitemid 38725017)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.6
, pp. 1431-1439
-
-
Raoof, A.A.1
Chiu, P.2
Ramtoola, Z.3
Cumming, I.K.4
Teng, C.5
Weinbach, S.P.6
Hardee, G.E.7
Levin, A.A.8
Geary, R.S.9
-
14
-
-
0033762244
-
Synchronized release of sulpiride and sodium decanoate from HPMC matrices: A rational approach to enhance sulpiride absorption in the rat intestine
-
Baluom M, Friedman M, Assaf P et al. Synchronized release of sulpiride and sodium decanoate from HPMC matrices: a rational approach to enhance sulpiride absorption in the rat intestine. Pharm. Res. 17, 1071-1076 (2000)
-
(2000)
Pharm. Res.
, vol.17
, pp. 1071-1076
-
-
Baluom, M.1
Friedman, M.2
Assaf, P.3
-
15
-
-
17844406157
-
Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery
-
DOI 10.2174/1567201052772834
-
Cano-Cebrian MJ, Zornoza T, Granero L et al. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr. Drug Deliv. 2, 9-22 (2005). (Pubitemid 40590917)
-
(2005)
Current Drug Delivery
, vol.2
, Issue.1
, pp. 9-22
-
-
Cano-Cebrian, M.J.1
Zornoza, T.2
Granero, L.3
Polache, A.4
-
16
-
-
85157279301
-
Cross-species comparison of the tolerability and effect of absorption enhancer on systemic delivery of antisense oligonucleotides following intra-intestinal administration
-
November
-
Geary RS, Teng CL, Raoof AA et al. Cross-species comparison of the tolerability and effect of absorption enhancer on systemic delivery of antisense oligonucleotides following intra-intestinal administration. Presented at: AAPS Annual Meeting. Indianapolis, IN, USA, 29 October-2 November 2000.
-
(2000)
Presented At: AAPS Annual Meeting Indianapolis in USA 29 October
, vol.2
-
-
Geary, R.S.1
Teng, C.L.2
Raoof, A.A.3
-
17
-
-
38049144195
-
In vitro interactions between the oral absorption promoter sodium caprate C10 and S typhimurium in rat intestinal ileal mucosae
-
Cox AB, Rawlinson LA, Baird AW et al. In vitro interactions between the oral absorption promoter, sodium caprate (C10) and S. typhimurium in rat intestinal ileal mucosae. Pharm. Res. 25(1), 114-122 (2008).
-
(2008)
Pharm. Res.
, vol.25
, Issue.1
, pp. 114-122
-
-
Cox, A.B.1
Rawlinson, L.A.2
Baird, A.W.3
-
18
-
-
46749122375
-
Safe and effective permeation enhancers for oral drug delivery
-
Whitehead K, Karr N, Mitragotri S. Safe and effective permeation enhancers for oral drug delivery. Pharm. Res. 25, 1782-1788 (2007).
-
(2007)
Pharm. Res.
, vol.25
, pp. 1782-1788
-
-
Whitehead, K.1
Karr, N.2
Mitragotri, S.3
|