Regional variability in symptom-based MELD exceptions: A response to organ shortage?

American Journal of Transplantation

Volumn 11, Issue 11, 2011, Pages 2353-2361

  Argo, C K ^a   Stukenborg, G J ^b   Schmitt, T M ^a   Kumer, S C ^a   Berg, C L ^a   Northup, P G ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Exception; Liver transplantation; MELD; Organ allocation; UNOS region; Waiting list

Indexed keywords

AGE DISTRIBUTION; BLOOD GROUP; CHOLESTATIC HEPATITIS; EDUCATIONAL STATUS; ETHNICITY; FUNCTIONAL STATUS; GENDER; HAZARD RATIO; HOSPITAL ADMISSION; HUMAN; LIVER CIRRHOSIS; LIVER DISEASE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MODEL FOR END STAGE LIVER DISEASE SCORING SYSTEM; NONALCOHOLIC FATTY LIVER; PREDICTIVE VALIDITY; PRIORITY JOURNAL; REVIEW; SCORING SYSTEM; SYMPTOM BASED EXCEPTION;

END STAGE LIVER DISEASE; FEMALE; HUMANS; LIVER TRANSPLANTATION; MALE; PATIENT SELECTION; TISSUE AND ORGAN PROCUREMENT; UNITED STATES; WAITING LISTS;

EID: 84857151419     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03738.x     Document Type: Review

References (31)

1. Wiesner R, Edwards E, Freeman R, et al. United Network for Organ Sharing Liver Disease Severity Score Committee. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91-96.
2. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-470. (Pubitemid 32119037)
3. Freeman R, Edwards E. Liver transplant waiting time does not correlate with waiting list mortality: Implications for liver allocation policy. Liver Transpl 2000; 6: 543-552.
4. Merion RM,Wolfe RA, Dykstra DM, et al. Longitudinal assessment of mortality risk among candidates for liver transplantation. Liver Transpl 2003; 9: 19-21.
5. Freeman RB, Wiesner RH, Roberts JP, et al. Improving liver allocation: MELD and PELD. Am J Transpl 2004; 4(Suppl 9): 114-131. (Pubitemid 38859000)
6. Freeman RB, Wiesner RH, Edwards E, et al. United Network for Organ Sharing Organ Procurement and Transplantation Network Liver and Transplantation Committee. Results of the first year of the new liver allocation plan. Liver Transpl 2004; 10: 7-15.
7. Freeman RB, Rohrer RJ, Katz E, et al. Preliminary results of a liver allocation plan using a continuous medical severity score that de-emphasizes waiting time. Liver Transpl 2001; 7: 173-178. (Pubitemid 32243810)
8. Wiesner RH, McDiarmid SV, Kamath PS, et al. MELD and PELD: Application of survival models to liver allocation. Liver Transpl 2001; 7: 567-580. (Pubitemid 32677880)
9. Saab S, Wang V, Ibrahim AB, et al. MELD score predicts 1-year survival post-orthotopic liver transplantation. Liver Transpl 2003; 9: 473-476. (Pubitemid 36621715)
10. Olthoff KM, Brown RS Jr., Delmonico FL, et al. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA. Liver Transpl 2004; 10 (Suppl 2): A6-A22. (Pubitemid 39406092)
11. Kremers WK, van IJperen M, KimWR, et al.MELD score as a predictor of pretransplant and posttransplant survival in OPTN/UNOS status 1 patients. Hepatology 2004; 39: 764-769. (Pubitemid 38337656)
12. Freeman RB, Harper A, Edwards EB. Excellent liver transplant survival rates under the MELD/PELD system. Transpl Proc 2005; 37: 585-588. (Pubitemid 40590634)
13. Freeman RB Jr., Wiesner RH, Harper A, et al. UNOS/OPTN liver disease severity score, UNOS/OPTN liver and intestine, and UNOS/OPTN pediatric transplantation committees. The new liver allocation system: Moving toward evidence-based transplantation policy. Liver Transpl 2002; 8: 851-858.
14. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. New Engl J Med 1996; 334: 693-699. (Pubitemid 26079803)
15. Llovet JM, Furster J, Bruix J. Intention to treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation. Hepatology 1999; 30: 1434-1440.
16. Figueras J, Jaurrieta E, Valls C, et al. Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: Outcomes based on indicated treatment strategy. J Am Coll Surg 2000; 190: 580-587. (Pubitemid 30230706)
17. Hemming AW, Cattral MS, Reed AI, et al. Liver transplantation for hepatocellular carcinoma. Ann Surg 2001; 233: 652-659. (Pubitemid 32378649)
18. Cheng SJ. Freeman RB, Wong JB. Predicting the probability of progression free survival in patients with small hepatocellular carcinoma. Liver Transpl 2002; 8: 323-328. (Pubitemid 34467364)
19. Wiesner RH, Freeman RB, Mulligan DC. Liver transplantation for hepatocellular cancer: The impact of the MELD allocation policy. Gastroenterology 2004; 127: S261-S267. (Pubitemid 39423395)
20. Rodriguez-Luna H, Vargas HE, Moss A, et al. Regional variations in peer reviewed liver allocation under the MELD system. Am J Transpl 2005; 5: 2244-2247. (Pubitemid 41648472)
21. Salvalaggio PR, Neighbors K, Kelly S, et al. Regional variation and use of exception letters for cadaveric liver allocation in children with chronic liver disease. Am J Transpl 2005; 1868-1874. (Pubitemid 41039859)
22. Freeman RB, Gish RG, Harper A, et al. Model for end-stage liver disease (MELD) exception guidelines: Results and recommendations from the MELD exception study group and conference (MESSAGE) for the approval of patients who need liver transplantation with diseases not considered by the standard MELD formula. Liver Transpl 2006: 12(S3): S128-S136. (Pubitemid 44911794)
23. Voigt MD, Zimmerman B, Katz DA, Rayhill SC. New national liver transplant allocation policy: Is the regional review board process fair? Liver Transpl 2004: 10: 666-674. (Pubitemid 38628228)
24. Fine JP, Gray RJ. A Proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999; 94: 496-509.
25. Kim WR, Therneau TM, Benson JT, et al. Deaths on the liver transplant waiting list: An analysis of competing risks. Hepatology 2006; 43: 345-351.
26. Berry SD, Ngo L, Samelson EJ, Kiel DP. Competing risk of death: An important consideration in studies of older adults. J Am Geriatr Soc 2010; 58: 783-787.
27. Satagopan JM, Ben-Porat L, Berwick M, Robson M, Kutler D, Auerbach AD. A note on competing risks in survival data analysis. Br J Cancer 2004; 91: 1229-1235. (Pubitemid 39424779)
28. Merion RM, Schaubel DE, Freeman R, et al. The survival benefit of liver transplantation. Am J Transplant 2005; 5: 307-313. (Pubitemid 40179517)
29. Biggins SW, Feng S. In aMELD-based economy, how can we fight off inflation? Liver Transpl 2007; 13: 2-4. (Pubitemid 46099965)
30. Heuman DM, Milhas AA, Habib A, et al. MELD-XI: A rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulation therapy. Liver Transpl 2007; 13: 30-37. (Pubitemid 46099971)
31. Gotthardt D, Weiss KH, Baumgartner M, et al. Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation. BMC Gastroenterol 2009; 9: 1-7.