Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing

Infection and Immunity

Volumn 80, Issue 1, 2012, Pages 143-149

  Cobo, Eduardo R ^a   He, Chen ^a   Hirata, Ken ^a   Hwang, Grace ^a   Tran, Uyenphuong ^a   Eckmann, Lars ^b   Gallo, Richard L ^b   Reed, Sharon L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CATHELIN RELATED ANTIMICROBIAL PEPTIDE; CYSTEINE PROTEINASE; UNCLASSIFIED DRUG;

AMEBIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; CONTROLLED STUDY; ENTAMOEBA HISTOLYTICA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; TROPHOZOITE; UPREGULATION; ANIMAL; BIOSYNTHESIS; C3H MOUSE; CELL LINE; CELL SURVIVAL; ENZYMOLOGY; EPITHELIUM CELL; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; PARASITOLOGY; PATHOGENICITY; PATHOLOGY;

ANIMALS; CATHELICIDINS; CELL LINE; CELL SURVIVAL; CYSTEINE PROTEASES; DYSENTERY, AMEBIC; ENTAMOEBA HISTOLYTICA; EPITHELIAL CELLS; HUMANS; IMMUNE EVASION; MALE; MICE; MICE, INBRED C3H; PROTEOLYSIS;

EID: 84857072070     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05029-11     Document Type: Article

References (32)

1. Asgharpour A, Gilchrist C, Baba D, Hamano S, Houpt E. 2005. Resistance to intestinal Entamoeba histolytica infection is conferred by innate immunity and Gr-1+ cells. Infect. Immun. 73:4522- 4529.
2. Braga LL, et al. 1992. Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica. J. Clin. Invest. 90:1131-1137.
3. Byfield FJ, et al. 2011. Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability. Am. J. Physiol. Cell Physiol. 300:C105-C112.
4. Eckmann L, Reed SL, Smith JR, Kagnoff MF. 1995. Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha. J. Clin. Invest. 96:1269 -1279.
5. Frick IM, Akesson P, Rasmussen M, Schmidtchen A, Bjorck L. 2003. SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides. J. Biol. Chem. 278:16561-16566.
6. Gallo RL, et al. 1997. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 272:13088 -13093.
7. Giacometti A, et al. 2003. In vitro effect on Cryptosporidium parvum of short-term exposure to cathelicidin peptides. J. Antimicrob. Chemother. 51:843- 847.
8. Gudmundsson GH, et al. 1996. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem. 238:325-332.
9. Haines LR, et al. 2009. Killing of trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18. PLoS Negl. Trop. Dis. 3:e373.
10. Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF. 2002. Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect. Immun. 70:953-963.
11. Hase K, et al. 2003. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 125:1613-1625.
12. He C, et al. 2010. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J. Biol. Chem. 285:18516 -18527.
13. Hou Y, Mortimer L, Chadee K. 2010. Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaBmediated pro-inflammatory responses. J. Biol. Chem. 285:35497-35504.
14. Houpt ER, et al. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J. Immunol. 169:4496-4503.
15. Iimura M, et al. 2005. Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 174:4901- 4907.
16. Islam D, et al. 2001. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat. Med. 7:180 -185.
17. Lidell ME, Moncada DM, Chadee K, Hansson GC. 2006. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc. Natl. Acad. Sci. U. S. A. 103:9298 -9303.
18. Llobet E, Tomas JM, Bengoechea JA. 2008. Capsule polysaccharide is a bacterial decoy for antimicrobial peptides. Microbiology 154:3877-3886.
19. McGwire BS, Olson CL, Tack BF, Engman DM. 2003. Killing of African trypanosomes by antimicrobial peptides. J. Infect. Dis. 188:146 -152.
20. Melendez-Lopez SG, et al. 2007. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot. Cell 6:1130 -1136.
21. Moncada D, Keller K, Ankri S, Mirelman D, Chadee K. 2006. Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation. Gastroenterology 130:721-730.
22. Moody S, Becker S, Nuchamowitz Y, Mirelman D. 1997. Virulent and avirulent Entamoeba histolytica and E. dispar differ in their cell surface phosphorylated glycolipids. Parasitology 114:95-104.
23. Mortimer L, Chadee K. 2010. The immunopathogenesis of Entamoeba histolytica. Exp. Parasitol. 126:366 -380.
24. Nizet V, Gallo RL. 2003. Cathelicidins and innate defense against invasive bacterial infection. Scand. J. Infect. Dis. 35:670-676.
25. Nizet V, et al. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457.
26. Reed S, et al. 1993. Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. J. Clin. Invest. 91:1532-1540.
27. Reed SL, et al. 1995. The extracellular neutral cysteine proteinase of Entamoeba histolytica degrades anaphylatoxins C3a and C5a. J. Immunol. 155:266 -274.
28. Reed SL, Keene WE, McKerrow JH, Gigli I. 1989. Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica. J. Immunol. 143:189-195.
29. Stanley SL, Jr. 2003. Amoebiasis. Lancet 361:1025-1034.
30. White JH. 2010. Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future. J. Steroid Biochem. Mol. Biol. 121:234 -238.
31. Yamasaki K, et al. 2006. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 20:2068 -2080.
32. Zaiou M, Gallo RL. 2002. Cathelicidins, essential gene-encoded mammalian antibiotics. J. Mol. Med. 80:549 -561.