A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib

International Journal of Clinical Oncology

Volumn 16, Issue 5, 2011, Pages 577-580

  Numakura, Kazuyuki ^a   Tsuchiya, Norihiko ^a   Yuasa, Takeshi ^a   Saito, Mitsuru ^a   Obara, Takashi ^a   Tsuruta, Hiroshi ^a   Narita, Shintaro ^a   Horikawa, Yohei ^a   Satoh, Shigeru ^a   Habuchi, Tomonori ^a  

^a AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fluorescence in situ hybridization; Renal cell carcinoma; Sunitinib; Xp11.2 translocation

Indexed keywords

SUNITINIB; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E3; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; TFE3 PROTEIN, HUMAN;

ABDOMINAL PAIN; ADULT; ARTICLE; CANCER REGRESSION; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE REDUCTION; DRUG EFFICACY; FATIGUE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE TRANSLOCATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; LAPAROSCOPIC SURGERY; LUNG METASTASIS; MULTIPLE CYCLE TREATMENT; NEPHRECTOMY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TRANSCRIPTION FACTOR E3 GENE; TUMOR CELL; TUMOR GENE; UNSPECIFIED SIDE EFFECT; XP11.2 TRANSLOCATION KIDNEY CARCINOMA; GENETICS; KIDNEY TUMOR; LUNG TUMOR; METABOLISM; METASTASIS; PATHOLOGY; X CHROMOSOME;

ADULT; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN, X; FEMALE; HUMANS; INDOLES; KIDNEY NEOPLASMS; LUNG NEOPLASMS; PYRROLES; TRANSLOCATION, GENETIC;

EID: 84857068818     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-010-0154-6     Document Type: Article

References (13)

1. Argani P, Antonescu CR, Illei PB et al (2001) Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma. Am J Pathol 159:179-192
2. Motzer RJ, Hutson TE, Tomczak P et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27:3584-3590
3. Winarti NW, Argani P, De Marzo AM et al (2008) Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion. Int J Surg Pathol 16:66-72
4. Choueiri TK, Mosquera JM, Hirsch MS (2009) A case of adult metastatic Xp11 translocation renal cell carcinoma treated successfully with sunitinib. Clin Genitourin Cancer 7:93-94
5. Zhong M, De Angelo P, Osborne L et al (2010) Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma. Am J Surg Pathol 34:757-766
6. Tsuda M, Davis IJ, Argani P et al (2007) TEF3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res 67:919-929
7. Malouf GG, Camparo P, Oudard S et al (2010) Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network. Ann Oncol 21:1834-1838
8. Mendel DB, Laird AD, Xin X et al (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9:327-337 (Pubitemid 36109749)
9. O'Farrell AM, Abrams TJ, Yuen HA et al (2003) SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101:3597-3605 (Pubitemid 36857948)
10. Chow LQM, Eckhardt SG (2007) Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25:884-896 (Pubitemid 350002890)
11. Stacchiotti S, Tamborini E, Marrari A et al (2009) Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res 15:1096-1104
12. Ivan M, Bond JA, Prat M et al (1997) Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene 14:2417-2423 (Pubitemid 27268160)
13. Wang SY, Chen B, Zhan YQ et al (2004) SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells. J Hepatol 41:267-273 (Pubitemid 39177631)