Off-label intravenous thrombolysis in acute stroke

European Journal of Neurology

Volumn 19, Issue 3, 2012, Pages 390-394

  Guillan, M ^a   Alonso Canovas, A ^a   Garcia Caldentey, J ^a   Sanchez Gonzalez, V ^a   Hernandez Medrano, I ^a   Defelipe Mimbrera, A ^a   Matute, M C ^a   Alonso Arias, M A ^a   Alonso de Lecinana M ^a   Masjuan, J ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Ischaemic stroke; Off label; Stroke Unit; Thrombolysis; TPA

Indexed keywords

ANTICOAGULANT AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ACUTE STROKE; AGED; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BREAST TUMOR; CHOLESTEATOMA; CHRONIC LIVER DISEASE; CLINICAL EXAMINATION; COLON TUMOR; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DISSEMINATED BREAST TUMOR; DRUG EFFICACY; DRUG SAFETY; HEAD INJURY; HUMAN; INTRACRANIAL TUMOR; MAJOR CLINICAL STUDY; MENINGIOMA; MORTALITY; NOSE TUMOR; OFF LABEL DRUG USE; ORTHOPEDIC SURGERY; OUTCOME ASSESSMENT; PACEMAKER; PARANASAL TUMOR; PERIANAL ABSCESS; PRIORITY JOURNAL; RANKIN SCALE; RISK ASSESSMENT; SEIZURE; STOMACH TUMOR; STROKE; SYSTEMIC HEMORRHAGE;

AGED; AGED, 80 AND OVER; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INFUSIONS, INTRAVENOUS; INTRACRANIAL HEMORRHAGES; MALE; OFF-LABEL USE; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84857064056     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2011.03517.x     Document Type: Article

References (15)

1. Wahlgren N, Ahmed N, Dávalos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007; 369: 275-282.
2. De Keyser J, Gdovinová Z, Uyttenboogaart M, Vroomen PC, Luijckx GJ. Intravenous alteplase for stroke: beyond the guidelines and in particular clinical situations. Stroke 2007; 38: 2612-2618.
3. Gómez-Choco M, Obach V, Urra X, et al. The response to IV rt-PA in very old stroke patients. Eur J Neurol 2008; 15: 253-256.
4. Engelter ST, Bonati LH, Lyrer PA. Intravenous thrombolysis in stroke patients of > or = 80 versus < 80years of age: a systematic review across cohort studies. Age Ageing 2006; 35: 572-578.
5. Ford GA, Ahmed N, Azevedo E, et al. Intravenous alteplase for stroke in those older than 80years old. Stroke 2010; 41: 2568-2574.
6. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with Alteplase 3 to 4.5hours after Acute Ischemic Stroke. N Eng J Med 2008; 359: 1317-1329.
7. Ahmed N, Wahlgren N, Grond M, et al. Implementation and outcome of thrombolysis with alteplase 3-4.5h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurol 2010; 9: 866-874.
8. Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke 1988; 19: 1497-1500.
9. Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375: 1695-1703.
10. Rubiera M, Ribo M, Santamarina E, et al. Is it time to reassess the SITS-MOST criteria for thrombolysis?: a comparison of patients with and without SITS-MOST exclusion criteria. Stroke 2009; 40: 2568-2571.
11. Meretoja A, Putaala J, Tatlisumak T, et al. Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke 2010; 41: 1450-1458.
12. Mishra NK, Davis SM, Kaste M, Lees KR; VISTA Collaboration. Comparison of outcomes following thrombolytic therapy among patients with prior stroke and diabetes in the Virtual International Stroke Trials Archive (VISTA). Diabetes Care 2010; 33: 2531-2537.
13. Aleu A, Mellado P, Lichy C, Köhrmann M, Schellinger PD. Haemorrhagic complications after off-label thrombolysis for ischemic stroke. Stroke 2007; 38: 417-422.
14. European Stroke Organization (ESO) Executive Committee, ESO Writing Committee. Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008. Heidelberg: European Stroke Organization, 2008.
15. Mandava P, Kent TA. Intra-arterial therapies for acute ischemic stroke. Neurology 2007; 68: 2132-2139.