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1
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58149398623
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Translation of the Philadelphia chromosome into therapy for CML
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Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112:4808-4817.
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(2008)
Blood
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Druker, B.J.1
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2
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33845444046
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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
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DOI 10.1056/NEJMoa062867
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Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355:2408-2417. (Pubitemid 44903745)
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New England Journal of Medicine
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Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
Deininger, M.W.N.7
Silver, R.T.8
Goldman, J.M.9
Stone, R.M.10
Cervantes, F.11
Hochhaus, A.12
Powell, B.L.13
Gabrilove, J.L.14
Rousselot, P.15
Reiffers, J.16
Cornelissen, J.J.17
Hughes, T.18
Agis, H.19
Fischer, T.20
Verhoef, G.21
Shepherd, J.22
Saglio, G.23
Gratwohl, A.24
Nielsen, J.L.25
Radich, J.P.26
Simonsson, B.27
Taylor, K.28
Baccarani, M.29
So, C.30
Letvak, L.31
Larson, R.A.32
more..
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3
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73349122639
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Chronic myeloid leukemia: An update of concepts and management recommendations of European Leukemia Net
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Baccarani M, Cortes J, Pane F, et al. Chronic myeloid leukemia: An update of concepts and management recommendations of European Leukemia Net. J Clin Oncol 2009; 27:6041-6051.
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J Clin Oncol
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Baccarani, M.1
Cortes, J.2
Pane, F.3
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4
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10744231480
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Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α
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DOI 10.1182/blood-2003-01-0025
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Cortes J, Giles F, O'Brien S, et al. Result of high-dose imatinib mesylate in patients with Philadelphia chromosome positive chronic myeloid leukemia after failure of interferon-Alpha. Blood 2003; 102:83-86. (Pubitemid 36759639)
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(2003)
Blood
, vol.102
, Issue.1
, pp. 83-86
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Cortes, J.1
Giles, F.2
O'Brien, S.3
Thomas, D.4
Garcia-Manero, G.5
Rios, M.B.6
Faderl, S.7
Verstovsek, S.8
Ferrajoli, A.9
Freireich, E.J.10
Talpaz, M.11
Kantarjian, H.12
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5
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11144354274
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High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
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DOI 10.1182/blood-2003-11-3800
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Kantarjian H, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004; 103:2873-2878. (Pubitemid 38451654)
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(2004)
Blood
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, pp. 2873-2878
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Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
Garcia-Manero, G.4
Verstovsek, S.5
Giles, F.6
Rios, M.B.7
Shan, J.8
Letvak, L.9
Thomas, D.10
Faderl, S.11
Ferrajoli, A.12
Cortes, J.13
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6
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75749105885
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Phase III, randomized, open-label study of daily imatinib mesylate 400mg versus 800mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: Tyrosine kinase inhibitor optimization and selectivity study
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The study concluded that continued follow-up is needed to determine the clinical significance of earlier responses on high-dose imatinib
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Cortes JE, Baccarani M, Guilhot F, et al. Phase III, randomized, open-label study of daily imatinib mesylate 400mg versus 800mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: Tyrosine kinase inhibitor optimization and selectivity study. J Clin Oncol 2010; 28:424-430. The study concluded that continued follow-up is needed to determine the clinical significance of earlier responses on high-dose imatinib.
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(2010)
J Clin Oncol
, vol.28
, pp. 424-430
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Cortes, J.E.1
Baccarani, M.2
Guilhot, F.3
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7
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77953723830
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24 months update of the TOPS study: A phase III, randomized open-label study of 400 mg/d (SD-IM) versus 800 mg/d (HD-IM) of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase
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abstract 337
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Baccarani M, Druker B, Cortes J, et al. 24 months update of the TOPS study: A phase III, randomized open-label study of 400 mg/d (SD-IM) versus 800 mg/d (HD-IM) of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase. Blood 2010; 114:abstract 337.
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(2010)
Blood
, vol.114
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Baccarani, M.1
Druker, B.2
Cortes, J.3
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8
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79955018499
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Tolerability-Adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-A in newly diagnosed chronic myeloid leukemia
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The study found that achievement of MMR by month 12 is directly associated with improved survival
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Hehlmann R, Lauseker M, Jung-Munkwitz S, et al. Tolerability-Adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-A in newly diagnosed chronic myeloid leukemia. J Clin Oncol 2011; 29:1634-1642. The study found that achievement of MMR by month 12 is directly associated with improved survival.
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(2011)
J Clin Oncol
, vol.29
, pp. 1634-1642
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Hehlmann, R.1
Lauseker, M.2
Jung-Munkwitz, S.3
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9
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78650625238
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Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia
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The study concluded that the addition of Peg-IFNa2a to imatinib therapy resulted in higher rates of molecular response in patients with CP-CM.L.
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Preudhomme C, Guilhot J, Nicolini FE, et al. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med 2010; 363:2511-2521. The study concluded that the addition of Peg-IFNa2a to imatinib therapy resulted in higher rates of molecular response in patients with CP-CML.
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(2010)
N Engl J Med
, vol.363
, pp. 2511-2521
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Preudhomme, C.1
Guilhot, J.2
Nicolini, F.E.3
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10
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79960348864
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High-dose imatinib for newly diagnosed chronic phase chronic myeloid leukemia patients: Systematic review and meta-Analysis
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Gafter-Gvili A, Leader A, Gurion R, et al. High-dose imatinib for newly diagnosed chronic phase chronic myeloid leukemia patients: Systematic review and meta-Analysis. Am J Hematol 2011; 86:657-662.
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(2011)
Am J Hematol
, vol.86
, pp. 657-662
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Gafter-Gvili, A.1
Leader, A.2
Gurion, R.3
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11
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66549108340
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Comparison of imatinib 400mg and 800mg daily in the front-line treatment of high-risk, Philadelphia-positive chronic myeloid leukemia: A European LeukemiaNet Study
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Baccarani M, Rosti G, Castagnetti F, et al. Comparison of imatinib 400mg and 800mg daily in the front-line treatment of high-risk, Philadelphia-positive chronic myeloid leukemia: A European LeukemiaNet Study. Blood 2009; 113:4497-4504.
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(2009)
Blood
, vol.113
, pp. 4497-4504
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Baccarani, M.1
Rosti, G.2
Castagnetti, F.3
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12
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79951506298
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Predicting response in CML
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Guilhot F, Guilhot J. Predicting response in CML. Blood 2011; 117:1773-1774.
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(2011)
Blood
, vol.117
, pp. 1773-1774
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Guilhot, F.1
Guilhot, J.2
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13
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79960685618
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Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: The EUTOS score
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Hasford J, Baccarani M, Hoffmann V, et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: The EUTOS score. Blood 2011; 118:686-692.
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(2011)
Blood
, vol.118
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Hasford, J.1
Baccarani, M.2
Hoffmann, V.3
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14
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80053977453
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European Treatment and Outcome Study (EUTO.S.score for chronic myeloid leukemia still requires more confirmation
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Marin D, Ibrahim AR, Goldman JM. European Treatment and Outcome Study (EUTOS) score for chronic myeloid leukemia still requires more confirmation. J Clin Oncol, 2011; 29:3944-3945.
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(2011)
J Clin Oncol
, vol.29
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Marin, D.1
Ibrahim, A.R.2
Goldman, J.M.3
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15
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79951477784
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Predictive factors for outcome and response in patients treated with second generation tyrosine kinase inhibitors for chronic myeloid leukemia in chronic phase post imatinib failure
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Jabbour E, Kantarjian H, O'Brien S, et al. Predictive factors for outcome and response in patients treated with second generation tyrosine kinase inhibitors for chronic myeloid leukemia in chronic phase post imatinib failure. Blood 2011; 117:1822-1827.
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(2011)
Blood
, vol.117
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Jabbour, E.1
Kantarjian, H.2
O'Brien, S.3
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16
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76549114789
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Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia
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Milojkovic D, Nicholson E, Apperley JF, et al. Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia. Haematologica 2010; 95:224-231.
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(2010)
Haematologica
, vol.95
, pp. 224-231
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Milojkovic, D.1
Nicholson, E.2
Apperley, J.F.3
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17
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75649084233
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A gene expression signature of CD34 cells to predict major cytogenetic response in chronic phase chronic myeloid leukemia patients treated with imatinib
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Mcweeney SK, Pemberton LC, Loriaux MM, et al. A gene expression signature of CD34 cells to predict major cytogenetic response in chronic phase chronic myeloid leukemia patients treated with imatinib. Blood 2010; 115:315-325.
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(2010)
Blood
, vol.115
, pp. 315-325
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Mcweeney, S.K.1
Pemberton, L.C.2
Loriaux, M.M.3
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18
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77958595179
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Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS)
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Hughes TP, Hochhaus A, Branford S, et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood 2010; 116:3758-3765.
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(2010)
Blood
, vol.116
, pp. 3758-3765
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Hughes, T.P.1
Hochhaus, A.2
Branford, S.3
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19
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80055101170
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The achievement of an early complete cytogenetic response is a major determinant for outcome in patients with early chronic phase chronic myeloid leukemia treated with tyrosine kinase inhibitors
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The study analyzed the association between achievement of early complete cytogenetic response and EFS in patients with newly diagnosed CM..L.
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Jabbour E, Kantarjian H, O'Brien S, et al. The achievement of an early complete cytogenetic response is a major determinant for outcome in patients with early chronic phase chronic myeloid leukemia treated with tyrosine kinase inhibitors. Blood 2011; 118:4541-4546. The study analyzed the association between achievement of early complete cytogenetic response and EFS in patients with newly diagnosed CML.
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(2011)
Blood
, vol.118
, pp. 4541-4546
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Jabbour, E.1
Kantarjian, H.2
O'Brien, S.3
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20
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84862907694
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Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
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doi:10.1200/JCO.2011.38.6565. [Epub ahead of print]
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Marin D, Ibrahim AR, Lucas C, et al. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol 2011. doi:10.1200/JCO.2011.38.6565. [Epub ahead of print]
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(2011)
J Clin Oncol
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Marin, D.1
Ibrahim, A.R.2
Lucas, C.3
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21
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77953691179
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Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
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The study evaluated the efficacy and safety of nilotinib in patients with newly diagnosed Philadelphia chromosome-positive CML in the chronic phase
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Saglio G, Kim DW, Issaragrisil S, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010; 362:2251-2259. The study evaluated the efficacy and safety of nilotinib in patients with newly diagnosed Philadelphia chromosome-positive CML in the chronic phase.
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(2010)
N Engl J Med
, vol.362
, pp. 2251-2259
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Saglio, G.1
Kim, D.W.2
Issaragrisil, S.3
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22
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77953725855
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Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
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The study concluded that dasatinib, compared with imatinib, induced significantly higher and faster rates of complete cytogenetic response and MM.R.
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Kantarjian H, Shah NP, Hochhaus A, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010; 362:2260-2270. The study concluded that dasatinib, compared with imatinib, induced significantly higher and faster rates of complete cytogenetic response and MMR.
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(2010)
N Engl J Med
, vol.362
, pp. 2260-2270
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Kantarjian, H.1
Shah, N.P.2
Hochhaus, A.3
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23
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84857051895
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Bosutinib versus imatinib in newly diagnosed chronic phase chronic myeloid leukemia: BELA trial: 24-month follow-up
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abstract 455
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Jorge E, Cortes JE, Maru A, Carmino De Souza CA, et al. Bosutinib versus imatinib in newly diagnosed chronic phase chronic myeloid leukemia: BELA trial: 24-month follow-up. Blood 2011; suupl. 1:abstract 455.
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(2011)
Blood
, Issue.SUPPL. 1
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Jorge, E.1
Cortes, J.E.2
Maru, A.3
Carmino De Souza, C.A.4
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24
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80052383499
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Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
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Kantarjian H, Hochhaus A, Saglio G, et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011; 12:841-851.
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(2011)
Lancet Oncol
, vol.12
, pp. 841-851
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Kantarjian, H.1
Hochhaus, A.2
Saglio, G.3
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25
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83655174011
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Dasatinib or imatinib (IM) in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Two-year follow-up from DASISIO.N
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abstract 6510
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Kantarjian H, Shah NP, Cortes JE. Dasatinib or imatinib (IM) in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): Two-year follow-up from DASISION. J Clin Oncol 2011; 29 (Suppl):abstract 6510.
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(2011)
J Clin Oncol
, Issue.SUPPL.
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Kantarjian, H.1
Shah, N.P.2
Cortes, J.E.3
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27
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78049528573
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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective multicentre Stop Imatinib (STIM) trial
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The study assessed whether imatinib can be discontinued without the occurrence of molecular relapse in patients in complete molecular remission
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Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol 2010; 11:1029-1035. The study assessed whether imatinib can be discontinued without the occurrence of molecular relapse in patients in complete molecular remission.
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(2010)
Lancet Oncol
, vol.11
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Mahon, F.X.1
Rea, D.2
Guilhot, J.3
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28
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80054122595
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Bcr-Abl signals to desensitize chronic myeloid leukemia cells to IFNa via accelerating the degradation of its receptor
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Bhattacharya S, Zheng H, Tzimas C, et al. Bcr-Abl signals to desensitize chronic myeloid leukemia cells to IFNa via accelerating the degradation of its receptor. Blood 2011; 118:4179-4187.
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(2011)
Blood
, Issue.118
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Bhattacharya, S.1
Zheng, H.2
Tzimas, C.3
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29
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80053130415
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Combination of pegylated interferon-Alpha2b with imatinib increases molecular response rates in patients with low or intermediate risk chronic myeloid leukemia
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The study found that lower doses of Peg-IFNa2b may enhance tolerability and could be considered in future protocols
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Simonsson B, Gedde-Dahl T, Markevarn B, et al. Combination of pegylated interferon-Alpha2b with imatinib increases molecular response rates in patients with low or intermediate risk chronic myeloid leukemia. Blood 2011; 118:3228-3235. The study found that lower doses of Peg-IFNa2b may enhance tolerability and could be considered in future protocols.
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(2011)
Blood
, vol.118
, pp. 3228-3235
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Simonsson, B.1
Gedde-Dahl, T.2
Markevarn, B.3
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30
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79952081141
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Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia
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Cortes J, Hochhaus A, Hughes T, et al. Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia. J Clin Oncol 2011; 29:524-533.
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(2011)
J Clin Oncol
, vol.29
, pp. 524-533
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Cortes, J.1
Hochhaus, A.2
Hughes, T.3
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31
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81155133285
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Front-line therapy with secondgeneration tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia what is the optimal response?
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Jabbour E, Kantarjian H, O'Brien S, et al. Front-line therapy with secondgeneration tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia: What is the optimal response? J Clin Oncol 2011; 29:4260-4265.
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(2011)
J Clin Oncol
, vol.29
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Jabbour, E.1
Kantarjian, H.2
O'Brien, S.3
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