Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation

European Journal of Clinical Pharmacology

Volumn 68, Issue 3, 2012, Pages 259-266

  Yano, Ikuko ^a,b   Masuda, Satohiro ^a   Egawa, Hiroto ^b,c   Sugimoto, Mitsuhiro ^a   Fukudo, Masahide ^a   Yoshida, Yuko ^a   Hashi, Sachiyo ^a   Yoshizawa, Atsushi ^b   Ogura, Yasuhiro ^b   Ogawa, Kohei ^b   Mori, Akira ^b   Kaido, Toshimi ^b   Uemoto, Shinji ^b   Inui, Ken Ichi ^a,d  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

LDLT; Pharmacodynamics; Pharmacokinetics; Therapeutic drug monitoring

Indexed keywords

CALCINEURIN; CORTICOSTEROID; TACROLIMUS;

ADULT; AREA UNDER THE CURVE; ARTICLE; CAUSE OF DEATH; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG MONITORING; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LIVER TRANSPLANTATION; LIVING DONOR; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MEDIAN EFFECTIVE CONCENTRATION; OPERATION DURATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHARMACODYNAMICS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

AREA UNDER CURVE; CALCINEURIN; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; TACROLIMUS;

EID: 84857063368     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1129-x     Document Type: Article

References (23)

1. JG O'Grady A Burroughs P Hardy D Elbourne A Truesdale 2002 Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial Lancet 360 9340 1119 1125 10.1016/S0140-6736(02)11196-2 12387959 10.1016/S0140-6736(02)11196-2
2. M Yasuhara T Hashida M Toraguchi Y Hashimoto M Kimura K Inui R Hori Y Inomata K Tanaka Y Yamaoka 1995 Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations Transplant Proc 27 1 1108 1110 7533356 1:STN:280:DyaK2M7osVequw%3D%3D
3. WJ Jusko W Piekoszewski GB Klintmalm MS Shaefer MF Hebert AA Piergies CC Lee P Schechter QA Mekki 1995 Pharmacokinetics of tacrolimus in liver transplant patients Clin Pharmacol Ther 57 3 281 290 10.1016/0009-9236(95)90153-1 7535213 10.1016/0009-9236(95)90153-1 1:STN:280:DyaK2M3ht1SrtA%3D%3D
4. R Venkataramanan A Swaminathan T Prasad A Jain S Zuckerman V Warty J McMichael J Lever G Burckart T Starzl 1995 Clinical pharmacokinetics of tacrolimus Clin Pharmacokinet 29 6 404 430 10.2165/00003088-199529060-00003 8787947 10.2165/00003088-199529060-00003 1:CAS:528:DyaK28XosFWntA%3D%3D (Pubitemid 26004179)
5. EM Scholten SC Cremers RC Schoemaker AT Rowshani EJ van Kan J den Hartigh LC Paul JW de Fijter 2005 AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients Kidney Int 67 6 2440 2447 10.1111/j.1523-1755.2005.00352.x 15882290 10.1111/j.1523-1755.2005.00352.x 1:CAS:528:DC%2BD2MXlsFyjurk%3D (Pubitemid 41623408)
6. M Cantarovich JS Barkun JI Tchervenkov JG Besner L Aspeslet P Metrakos 1998 Comparison of neoral dose monitoring with cyclosporine through levels versus 2-h postdose levels in stable liver transplant patients Transplantation 66 12 1621 1627 9884249 10.1097/00007890-199812270-00009 1:CAS:528: DyaK1MXmvFaqtA%3D%3D (Pubitemid 29034981)
7. G Levy P Burra A Cavallari C Duvoux J Lake AD Mayer S Mies SG Pollard E Varo F Villamil A Johnston 2002 Improved clinical outcomes for liver transplant recipients using cyclosporine monitoring based on 2-h post-dose levels (C2) Transplantation 73 6 953 959 11923699 10.1097/00007890-200203270-00022 1:CAS:528:DC%2BD38XjtFShsLc%3D (Pubitemid 34252362)
8. S Fukatsu I Yano T Igarashi T Hashida K Takayanagi H Saito S Uemoto T Kiuchi K Tanaka K Inui K Tanaka K Inui 2001 Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation Eur J Clin Pharmacol 57 6-7 479 484 10.1007/s002280100331 11699612 1:CAS:528:DC%2BD3MXotlyku7Y%3D (Pubitemid 34507515)
9. M Fukudo I Yano S Fukatsu H Saito S Uemoto T Kiuchi K Tanaka K Inui 2003 Forecasting of blood tacrolimus concentrations based on the Bayesian method in adult patients receiving living-donor liver transplantation Clin Pharmacokinet 42 13 1161 1178 10.2165/00003088-200342130-00006 14531726 10.2165/00003088- 200342130-00006 1:CAS:528:DC%2BD3sXpsF2ls7Y%3D (Pubitemid 37357651)
10. I Yano 2008 Pharmacodynamic monitoring of calcineurin phosphatase activity in transplant patients treated with calcineurin inhibitors Drug Metab Pharmacokinet 23 3 150 157 10.2133/dmpk.23.150 18574318 10.2133/dmpk.23.150 1:CAS:528:DC%2BD1cXhtVSis73P
11. M Fukudo I Yano S Masuda S Fukatsu T Katsura Y Ogura F Oike Y Takada K Tanaka K Inui 2005 Pharmacodynamic analysis of tacrolimus and cyclosporine in patients of living-donor liver transplantation Clin Pharmacol Ther 78 2 168 181 10.1016/j.clpt.2005.04.008 16084851 10.1016/j.clpt.2005.04.008 1:CAS:528:DC%2BD2MXnslyhtLk%3D (Pubitemid 41112285)
12. M Fukudo I Yano S Masuda T Katsura Y Ogura F Oike Y Takada K Tanaka K Inui 2006 Cyclosporine exposure and calcineurin phosphatase activity in living-donor liver transplant patients: twice daily vs. once daily dosing Liver Transpl 12 2 292 300 10.1002/lt.20609 16447186 10.1002/lt.20609 (Pubitemid 43273790)
13. M Shimomura S Masuda M Goto T Katsura T Kiuchi Y Ogura F Oike Y Takada S Uemoto K Inui 2008 Required transient dose escalation of tacrolimus in living-donor liver transplant recipients with high concentrations of a minor metabolite M-II in bile Drug Metab Pharmacokinet 23 5 313 317 10.2133/dmpk.23.313 18974608 10.2133/dmpk.23.313 1:CAS:528:DC%2BD1cXhsFahsLvF
14. JF Trotter M Wachs GT Everson I Kam 2002 Adult-to-adult transplantation of the right hepatic lobe from a living donor N Engl J Med 346 14 1074 1082 10.1056/NEJMra011629 11932476 10.1056/NEJMra011629 (Pubitemid 34984623)
15. K Tanaka T Kiuchi S Kaihara 2004 Living related liver donor transplantation: techniques and caution Surg Clin North Am 84 2 481 493 10.1016/j.suc.2003.12.006 15062657 10.1016/j.suc.2003.12.006 (Pubitemid 38388279)
16. S Masuda K Inui 2006 An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients Pharmacol Ther 112 1 184 198 10.1016/j.pharmthera.2006.04.006 16759707 10.1016/j.pharmthera. 2006.04.006 1:CAS:528:DC%2BD28XptFCitrY%3D (Pubitemid 44301492)
17. S Masuda M Goto S Fukatsu M Uesugi Y Ogura F Oike T Kiuchi Y Takada K Tanaka K Inui 2006 Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients Clin Pharmacol Ther 79 1 90 102 10.1016/j.clpt.2005.09.013 16413244 10.1016/j.clpt.2005.09.013 1:CAS:528:DC%2BD28XksVGktA%3D%3D (Pubitemid 43069581)
18. Z Wlodarczyk JP Squifflet M Ostrowski P Rigotti S Stefoni F Citterio Y Vanrenterghem BK Krämer D Abramowicz F Oppenheimer F Pietruck G Russ C Karpf N Undre 2009 Pharmacokinetics for once- versus twice-daily tacrolimus formulations in de novo kidney transplantation: a randomized, open-label trial Am J Transplant 9 11 2505 2513 10.1111/j.1600-6143.2009.02794.x 19681813 10.1111/j.1600-6143.2009.02794.x 1:CAS:528:DC%2BD1MXhsVyisbvM
19. L Kung PF Halloran 2000 Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations Transplantation 70 2 327 335 10933159 10.1097/00007890-200007270-00017 1:CAS:528:DC%2BD3cXlvVOlt7o%3D (Pubitemid 30602753)
20. M Goto S Masuda T Kiuchi Y Ogura F Oike K Tanaka S Uemoto K Inui 2008 Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation J Pharmacol Exp Ther 325 2 610 616 10.1124/jpet.107.135665 18252812 10.1124/jpet.107.135665 1:CAS:528:DC%2BD1cXlsVOjt70%3D (Pubitemid 351574803)
21. HH van Rossum FP Romijn KJ Sellar NP Smit PJ van der Boog JW de Fijter J van Pelt 2008 Variation in leukocyte subset concentrations affects calcineurin activity measurement: implications for pharmacodynamic monitoring strategies Clin Chem 54 3 517 524 10.1373/clinchem.2007.097253 18218723 10.1373/clinchem.2007.097253 (Pubitemid 351348159)
22. B Blanchet C Duvoux CE Costentin C Barrault B Ghaleh A Salvat H Jouault A Astier M Tod A Hulin 2008 Pharmacokinetic-pharmacodynamic assessment of tacrolimus in liver-transplant recipients during the early post-transplantation period Ther Drug Monit 30 4 412 418 10.1097/FTD.0b013e318178e31b 18641556 1:CAS:528:DC%2BD1cXpsVCiurw%3D
23. M Fukudo I Yano T Katsura N Ito S Yamamoto T Kamoto O Ogawa K Inui 2010 A transient increase of calcineurin phosphatase activity in living-donor kidney transplant recipients with acute rejection Drug Metab Pharmacokinet 25 5 411 417 10.2133/dmpk.DMPK-10-RG-026 20834189 10.2133/dmpk.DMPK-10-RG-026 1:CAS:528:DC%2BC3cXhs1artLzP