The elderly patient with surgically resected non-small cell lung cancer - A distinct situation?

Experimental Gerontology

Volumn 47, Issue 3, 2012, Pages 237-242

  Sterlacci, William ^a   Stockinger, Richard ^a   Schmid, Thomas ^b   Bodner, Johannes ^b   Hilbe, Wolfgang ^c   Waldthaler, Christian ^c   Oberaigner, Wilhelm ^d   Tzankov, Alexandar ^e   Fiegl, Michael ^c  

^a University Teaching Hospital Feldkirch   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d TILAK   (Austria)

^e UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Clinical and pathological characteristics; Elderly; Non small cell lung cancer; Recurrence; Surgical resection

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; KI 67 ANTIGEN; LACTATE DEHYDROGENASE;

ADULT; AGE; AGED; ARTICLE; CANCER GRADING; CANCER RECURRENCE; CANCER STAGING; CIGARETTE SMOKING; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HEALTH STATUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; SEX DIFFERENCE; TUMOR DIFFERENTIATION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIFFERENTIATION; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RECURRENCE; SMOKING; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84857062389     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.12.008     Document Type: Article

References (28)

1. Berry M.F., Hanna J., Tong B.C., Burfeind W.R., Harpole D.H., D'Amico T.A., Onaitis M.W. Risk factors for morbidity after lobectomy for lung cancer in elderly patients. Ann. Thorac. Surg. 2009, 88:1093-1099.
2. Birim O., Zuydendorp H.M., Maat A.P., Kappetein A.P., Eijkemans M.J., Bogers A.J. Lung resection for non-small-cell lung cancer in patients older than 70: mortality, morbidity, and late survival compared with the general population. Ann. Thorac. Surg. 2003, 76:1796-1801.
3. Blanchard E.M., Arnaoutakis K., Hesketh P.J. Lung cancer in octogenarians. J. Thorac. Oncol. 2010, 5:909-916.
4. Brown J.S., Eraut D., Trask C., Davison A.G. Age and the treatment of lung cancer. Thorax 1996, 51:564-568.
5. Cerfolio R.J., Bryant A.S. Survival and outcomes of pulmonary resection for non-small cell lung cancer in the elderly: a nested case control study. Ann. Thorac. Surg. 2006, 82:424-429.
6. Chambers A., Routledge T., Pilling J., Scarci M. In elderly patients with lung cancer is resection justified in terms of morbidity, mortality and residual quality of life?. Interact. Cardiovasc. Thorac. Surg. 2010, 10:1015-1021.
7. Dyszkiewicz W., Pawlak K., Gasiorowski L. Early post-pneumonectomy complications in the elderly. Eur. J. Cardiothorac. Surg. 2000, 17:246-250.
8. European Union Demography Report 2010 2011, STAT/11/50, 1 April.
9. Extermann M. Studies of comprehensive geriatric assessment in patients with cancer. Cancer Control 2003, 10:463-468.
10. Fanucchi O., Ambrogi M.C., Dini P., Lucchi M., Melfi F., Davini F., Mussi A. Surgical treatment of non-small cell lung cancer in octogenarians. Interact. Cardiovasc. Thorac. Surg. 2011, 12:749-753.
11. Federal Statistical Office of Germany Resident population estimates of the Federal Republic of Germany by age and sex last accessed July 19th 2011. http://www.destatis.de.
12. Fiegl M., Hilbe W., Auberger J., Schmid T., Auberger T., Tzankov A., Sterlacci W., Denz H., Jamnig H., Greil R. Twelve-year retrospective analysis of lung cancer - the TYROL Study: daily routine in 1,424 patients (1995-2006). J. Clin. Oncol. 2008, 26. abstr 19063.
13. Goodgame B., Viswanathan A., Zoole J., Gao F., Miller C.R., Subramanian J., Meyers B.F., Patterson A.G., Govindan R. Risk of recurrence of resected stage I non-small cell lung cancer in elderly patients as compared with younger patients. J. Thorac. Oncol. 2009, 4:1370-1374.
14. Hilbe W., Aigner K., Dittrich C., Eckmayr J., Fiegl M., Flicker M., Forstner B., Greil R., Jamnig H., Krajnik G., Lang A., Mohn-Staudner A., Schinko H., Studnicka M., Pirker R., Ploner F., Rothmund J., Schiller L., Zabernigg A., Zöchbauer-Müller S. Expert recommendations 2006 on the rationale for second-line therapy for non-small cell bronchial neoplasms. Wien. Klin. Wochenschr. 2007, 119:259-266.
15. Janssen-Heijnen M.L., Smulders S., Lemmens V.E., Smeenk F.W., van Geffen H.J., Coebergh J.W. Effect of comorbidity on the treatment and prognosis of elderly patients with non-small cell lung cancer. Thorax 2004, 59:602-607.
16. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics, CA. Cancer J. Clin. 2011, 61:69-90.
17. National Cancer Institute SEER Cancer Statistics Review 1973-1997 2000, National Cancer Institute, Bethesda, MD.
18. Rivera C., Falcoz P.E., Bernard A., Thomas P., Dahan M. Surgical management and outcomes of elderly patients with early stage of non-small cell lung cancer: a nested case control study. Chest 2011, 140:874-880.
19. Sawada S., Komori E., Nogami N., Bessho A., Segawa Y., Shinkai T., Nakata M., Yamashita M. Advanced age is not correlated with either short-term or long-term postoperative results in lung cancer patients in good clinical condition. Chest 2005, 128:1557-1563.
20. Stauder R., Nösslinger T., Pfeilstöcker M., Sperr W.R., Wimazal F., Krieger O., Valent P. Impact of age and comorbidity in myelodysplastic syndromes. J. Natl. Compr. Canc. Netw. 2008, 6:927-934.
21. Sterlacci W., Fiegl M., Hilbe W., Auberger J., Mikuz G., Tzankov A. Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases. Virchows. Arch. 2009, 455:125-132.
22. Sterlacci W., Fiegl M., Hilbe W., Jamnig H., Oberaigner W., Schmid T., Augustin F., Auberger J., Obermann E.C., Tzankov A. Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients. J. Thorac. Oncol. 2010, 5:1325-1336.
23. Sterlacci W., Tzankov A., Veits L., Oberaigner W., Schmid T., Hilbe W., Fiegl M. The prognostic impact of sex for surgically resected non-small cell lung cancer depends on clinicopathological characteristics. Am. J. Clin. Pathol. 2011, 135:611-618.
24. Stewart J.H., Bertoni A.G., Staten J.L., Levine E.A., Gross C.P. Participation in surgical oncology clinical trials: gender-, race/ethnicity-, and age based disparities. Ann. Surg. Oncol. 2007, 14:3328-3334.
25. Takamochi K., Oh S., Matsuoka J., Suzuki K. Risk factors for morbidity after pulmonary resection for lung cancer in younger and elderly patients. Interact. Cardiovasc. Thorac. Surg. 2011, 12:739-743.
26. Tomaszek S.C., Wigle D.A. Surgical management of lung cancer. Semin. Respir. Crit. Care Med. 2011, 32:69-77.
27. Travis W., Brambilla E., Müller-Hermelink H., Harris C. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart 2004, IARCPress, Lyon, France.
28. VanderWalde A., Pal S.K., Reckamp K.L. Management of non-small-cell lung cancer in the older adult. Maturitas 2011, 68:311-321.