Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection

Journal of Emergency Medicine

Volumn 42, Issue 2, 2012, Pages 127-132

  Fischer, Christopher M ^a   Yano, Kiichiro ^a   Aird, William C ^a   Shapiro, Nathan I ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

coagulation; hematology; infection

Indexed keywords

ABNORMAL LABORATORY RESULT; ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TEST; COMORBIDITY; CONFIDENCE INTERVAL; DISEASE SEVERITY; EMERGENCY WARD; ENDOCARDITIS; FEMALE; FEVER; HUMAN; INFLAMMATION; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; MENINGITIS; MORTALITY; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SECONDARY ANALYSIS; SKIN INFECTION; SOFT TISSUE INFECTION; TERTIARY HEALTH CARE; THROMBOCYTE COUNT; URBAN AREA; URINARY TRACT INFECTION;

AGED; AGED, 80 AND OVER; BLOOD COAGULATION TESTS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HOSPITALS, UNIVERSITY; HOSPITALS, URBAN; HUMANS; INFECTION; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES;

EID: 84857048942     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2010.05.007     Document Type: Article

References (36)

1. D.C. Angus, W.T. Linde-Zwirble, G. Lidicker, G. Clermont, J. Carcillo, R. Pinsky Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303 1310 (Pubitemid 32641789)
2. H.E. Wang, N.I. Shapiro, D.C. Angus, D.M. Yealy National estimates of severe sepsis in United States emergency departments Crit Care Med 35 2007 1928 1936 (Pubitemid 47220368)
3. E. Rivers, B. Nguyen, S. Havstad Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med 345 2001 1368 1377
4. N.I. Shapiro, M.D. Howell, D. Talmore Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol Crit Care Med 34 2006 1025 1032
5. N.I. Shapiro, M.D. Howell, D.W. Bates, D.C. Angus, L. Ngo, D. Talmore The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection Ann Emerg Med 48 2006 583 590 590.e1
6. M.M. Levy, W.L. Macias, J.L. Vincent Early changes in organ function predict eventual survival in severe sepsis Crit Care Med 33 2005 2194 2201
7. W.C. Aird The hematologic system as a marker of organ dysfunction in sepsis Mayo Clin Proc 78 2003 869 881 (Pubitemid 36759296)
8. C.T. Esmon The interactions between inflammation and coagulation Br J Haematol 131 2005 417 430 (Pubitemid 43899639)
9. M. Levi, H. Ten Cate Disseminated intravascular coagulation N Engl J Med 341 1999 586 592 (Pubitemid 29384168)
10. G.T. Kinasewitz, J.G. Zein, G.L. Lee, S.A. Nazir, F.B. Taylor Jr Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis Crit Care Med 33 2005 2214 2221 (Pubitemid 41437473)
11. B. White, D. Perry Acquired antithrombin deficiency in sepsis Br J Haematol 112 2001 26 31 (Pubitemid 32151144)
12. S. Madoiwa, S. Nunomiya, T. Ono Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation Int J Hematol 84 2006 398 405 (Pubitemid 46052628)
13. G.R. Bernard, J.L. Vincent, P.F. Laterre Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 2001 699 709 (Pubitemid 32204987)
14. S.B. Yan, J.D. Helterbrand, D.L. Hartman, T.J. Wright, G.R. Bernard Low levels of protein C are associated with poor outcome in severe sepsis Chest 120 2001 915 922 (Pubitemid 32885469)
15. N.I. Shapiro, R.E. Wolfe, R.B. Moore, E. Smith, E. Burdick, D.W. Bates Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule Crit Care Med 31 2003 670 675 (Pubitemid 36379566)
16. M.E. Charlson, P. Pompei, K.L. Ales, C.R. MacKenzie A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 1987 373 383 (Pubitemid 17055592)
17. S.B. Murray, D.W. Bates, L. Ngo, J.W. Ufberg, N.I. Shapiro Charlson Index is associated with one-year mortality in emergency department patients with suspected infection Acad Emerg Med 13 2006 530 536 (Pubitemid 44316644)
18. N.I. Shapiro, M.D. Howell, D. Talmor, M. Donnino, L. Ngo, D.W. Bates Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality Crit Care Med 35 2007 192 198 (Pubitemid 46035695)
19. J.D. Sankoff, M. Goyal, D.F. Gaieski Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS) Crit Care Med 36 2008 421 426 (Pubitemid 351158614)
20. G.T. Kinasewitz, S.B. Yan, B. Basson Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569] Crit Care 8 2004 R82 R90
21. B.L. Warren, A. Eid, P. Singer Caring for the critically ill patient High-dose antithrombin III in severe sepsis: a randomized controlled trial JAMA 286 2001 1869 1878 (Pubitemid 33010239)
22. E. Abraham, A. Anzueto, G. Gutierrez Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock NORASEPT II Study Group Lancet 351 1998 929 933 (Pubitemid 28138465)
23. S.M. Opal, C.J. Fisher Jr, J.F. Dhainaut Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial The Interleukin-1 Receptor Antagonist Sepsis Investigator Group Crit Care Med 25 1997 1115 1124 (Pubitemid 27310249)
24. M. Mori, H. Kudo, S. Yoshitake, K. Ito, C. Shinguu, T. Noguchi Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis Intensive Care Med 26 2000 218 220 (Pubitemid 30186599)
25. F. Stephan, M.A. Cheffi, C. Kaplan Autoantibodies against platelet glycoproteins in critically ill patients with thrombocytopenia Am J Med 108 2000 554 560 (Pubitemid 30249033)
26. B. Francois, F. Trimoreau, P. Vignon, P. Fixe, V. Praloran, H. Gastinne Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor Am J Med 103 1997 114 120 (Pubitemid 27352115)
27. T.E. Warkentin, W.C. Aird, J.H. Rand Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome Hematology Am Soc Hematol Educ Program 2003 497 519
28. T. Pernerstorfer, P. Stohlawetz, U. Hollenstein Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen Arterioscler Thromb Vasc Biol 19 1999 2517 2523 (Pubitemid 29477854)
29. A.F. Suffredini, P.C. Harpel, J.E. Parrillo Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects N Engl J Med 320 1989 1165 1172 (Pubitemid 19124297)
30. J. Philippe, F. Offner, P.J. Declerck Fibrinolysis and coagulation in patients with infectious disease and sepsis Thromb Haemost 65 1991 291 295
31. S.N. Faust, M. Levin, O.B. Harrison Dysfunction of endothelial protein C activation in severe meningococcal sepsis N Engl J Med 345 2001 408 416 (Pubitemid 32747604)
32. C. Brun-Buisson, F. Doyon, J. Carlet Incidence, risk factors, and outcome of severe sepsis and septic shock in adults A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis JAMA 274 1995 968 974
33. S. Akca, P. Haji-Michael, A. de Mendona, P. Suter, M. Levi, J.L. Vincent Time course of platelet counts in critically ill patients Crit Care Med 30 2002 753 756 (Pubitemid 34297789)
34. M.A. Martinez, J.M. Pea, A. Fernndez Time course and prognostic significance of hemostatic changes in sepsis: relation to tumor necrosis factor-alpha Crit Care Med 27 1999 1303 1308 (Pubitemid 29379368)
35. J.C. Marshall, D.J. Cook, N.V. Christou, G.R. Bernard, C.L. Sprung, W.J. Sibbald Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome Crit Care Med 23 1995 1638 1652
36. F. Fourrier, C. Chopin, J. Goudemand Septic shock, multiple organ failure, and disseminated intravascular coagulation Compared patterns of antithrombin III, protein C, and protein S deficiencies Chest 101 1992 816 823