Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo

Biochemical Pharmacology

Volumn 83, Issue 6, 2012, Pages 733-740

  Chattopadhyay, Mitali ^a   Kodela, Ravinder ^a   Nath, Niharika ^b   Street, Cherease R ^a   Velázquez Martínez, Carlos A ^c   Boring, Daniel ^d   Kashfi, Khosrow ^a  

^a CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

^b NEW YORK INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CYP 1A1; GST; Hydrogen sulfide; NOQ1; NSAIDs; UGT; Xenobiotic metabolizing enzymes

Indexed keywords

ACETYLSALICYLIC ACID; ESTERASE INHIBITOR; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HYDROGEN SULFIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CULTURE; CELL GROWTH; COLON; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LIVER CANCER; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; XENOBIOTIC METABOLISM;

ANIMALS; ASPIRIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROME P-450 CYP1A1; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HT29 CELLS; HUMANS; HYDROGEN SULFIDE; INHIBITORY CONCENTRATION 50; LIVER; MALE; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASMS; NF-E2-RELATED FACTOR 2; RATS; RATS, WISTAR; SODIUM FLUORIDE; THIONES;

EID: 84857047606     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.12.020     Document Type: Article

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