Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters

Parasitology Research

Volumn 110, Issue 2, 2012, Pages 515-520

  Polat, Zubeyde Akin ^a   Obwaller, Andreas ^b   Vural, Ayse ^a   Walochnik, Julia ^c  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b Orphanidis Pharma Research GmbH   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAMEBIC AGENT; MILTEFOSINE; POLYHEXANIDE; POLYHEXANIDE PLUS PROPAMIDINE ISETHIONATE; PROPAMIDINE ISETHIONATE; UNCLASSIFIED DRUG;

ACANTHAMOEBA KERATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA NEOVASCULARIZATION; CORNEA OPACITY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; HUMIDITY; INFECTION CONTROL; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; TREATMENT RESPONSE;

ACANTHAMOEBA; ACANTHAMOEBA KERATITIS; ADMINISTRATION, TOPICAL; ANIMALS; ANTIPROTOZOAL AGENTS; BENZAMIDINES; BIGUANIDES; CRICETINAE; DISEASE MODELS, ANIMAL; HUMANS; MALE; MESOCRICETUS; PHOSPHORYLCHOLINE; TREATMENT OUTCOME;

ACANTHAMOEBA; ACANTHAMOEBA HATCHETTI; CRICETINAE; MESOCRICETUS AURATUS;

EID: 84857043543     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-011-2515-0     Document Type: Article

References (30)

1. Aichelburg AC, Walochnik J, Assadian O, Prosch H, Steuer A, Perneczky G, Visvesvara GS, Aspöck H, Vetter N (2008) Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine. Emerg Infect Dis 14:1743-1746
2. Blaha C, Duchêne M, Aspöck H, Walochnik J (2006) In vitro activity of hexadecylphosphocholine (miltefosine) against metronidazoleresistant and -susceptible strains of Trichomonas vaginalis. J Antimicrob Chemother 57:273-278 (Pubitemid 43160169)
3. Chong EM, Dana MR (2007) Acanthamoeba keratitis. Int Ophthalmol Clin 47:33-46 (Pubitemid 46725802)
4. Claerhout I, Goegebuer A, Van Den Broecke C, Kestelyn P (2004) Delay in diagnosis and outcome of Acanthamoeba keratitis. Graefes Arch Clin Exp Ophthalmol 242:648-653 (Pubitemid 39242839)
5. Eibl H, Unger C (1990) Hexadecylphosphocholine: A new and selective antitumor drug. Cancer Treat Rev 17:233-242
6. Elder MJ, Kilvington S, Dart JKG (1994) A clinicopathologic study of in vitro sensitivity testing and Acanthamoeba keratitis. Invest Ophthalmol Vis Sci 35:1059-1064 (Pubitemid 24079838)
7. Ficker L, Hunter P, Seal D, Wright P (1989) Acanthamoeba keratitis occurring with disposable contact lens wear. Am J Ophthalmol 108:453 (Pubitemid 19259214)
8. Ficker L, Seal D,Warhurst D,Wright P (1990) Acanthamoeba keratitis- resistance to medical therapy. Eye 4:835-838
9. Khandpur S, Chaturvedi P, Kumar U, Khaitan BK, Samantaray JC, Sharma VK (2010) Oral miltefosine in post-kala-azar dermal leishmaniasis-experience in three cases. Int J Dermatol 49:565-569
10. Kumar R, Lloyd D (2002) Recent advances in the treatment of Acanthamoeba keratitis. Clin Infect Dis 35:434-441 (Pubitemid 34852574)
11. Lee JE, Oum BS, Choi HY, Yu HS, Lee JS (2007) Cysticidal effect on Acanthamoeba and toxicity on human keratocytes by polyhexamethylene biguanide and chlorhexidine. Cornea 26:736-741 (Pubitemid 47080296)
12. Lorenzo-Morales J, Martínez-Carretero E, Batista N, Alvarez-Marín J, Bahaya Y, Walochnik J, Valladares B (2007) Early diagnosis of amoebic keratitis due to a mixed infection with Acanthamoeba and Hartmannella. Parasitol Res 102:167-169 (Pubitemid 47628592)
13. Marciano-Cabral F, Cabral G (2003) Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev 16:273-307 (Pubitemid 36519813)
14. McBride J, Ingram PR, Henriquez FL, Roberts CW (2005) Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba. J Clin Microbiol 43:629-634 (Pubitemid 40256011)
15. Pens CJ, Costa M, Fadanelli C, Caumo K, Rott M (2008) Acanthamoeba spp. and bacterial contamination in contact lens storage cases and the relationship to user profiles. Parasitol Res 103:1241-1245
16. Polat ZA, Ozcelik S, Vural A, Cetin A (2007) Clinical and histologic evaluations of experimental Acanthamoeba keratitis. Parasitol Res 101:1621-1625 (Pubitemid 47524852)
17. Reinhard T, Sundmacher R (2000) Clinical aspects and therapy of Acanthamoeba keratitis. Ophthalmologe 97:446-459 (Pubitemid 30435534)
18. Santa-Rita RM, Santos Barbosa H, Meirelles MN, de Castro SL (2000) Effect of the alkyllysophospholipids on the proliferation and differentiation of Trypanosoma cruzi. Acta Trop 75:219-228 (Pubitemid 30120033)
19. Scheid P, Zöller L, Pressmar S, Richard G, Michel R (2008) An extraordinary endocytobiont in Acanthamoeba sp. isolated from a patient with keratitis. Parasitol Res 102:945-950
20. Schuster FL (2002) Cultivation of pathogenic and opportunistic freeliving amebas. Clin Microbiol Rev 15:342-354 (Pubitemid 34761344)
21. Seal D (2003) Treatment of Acanthamoeba keratitis. Expert Rev Anti Infect Ther 1:205-208 (Pubitemid 38855083)
22. Seifert K, Duchêne M, Wernsdorfer WH, Kollaritsch H, Scheiner O, Wiedermann G, Hottkowitz T, Eibl H (2001) Effects of miltefosine and other alkylphosphocholines on human intestinal parasite Entamoeba histolytica. Antimicrob Agents Chemother 45:1505-1510 (Pubitemid 32374125)
23. Singhal T, Bajpai A, Kalra V, Kabra SK, Samantaray JC, Satpathy G, Gupta AK (2001) Successful treatment of disseminated Acanthamoeba infection in an immunocompromised patient. Pediatr Infect Dis J 20:623-627 (Pubitemid 32567727)
24. Tseng SH, Lin SC, Chen FK (1998) Is polyhexamethylene biguanide alone effective for Acanthamoeba keratitis? Cornea 7:345-347
25. Varga JH, Wolf TC, Jensen HG, Parmley VC, Rowsey JJ (1993) Combined treatment of Acanthamoeba keratitis with propamidine, neomycin, and polyhexamethylene biguanide. Am J Ophthalmol 115:466-470 (Pubitemid 23109798)
26. Verma NK, Dey CS (2004) Possible mechanism of miltefosinemediated death of Leishmania donovani. Antimicrob Agents Chemother 48:3010-3015 (Pubitemid 38992329)
27. Visvesvara GS, Moura H, Schuster FL (2007) Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol Med Microbiol 50:1-26 (Pubitemid 46763469)
28. Walochnik J, Duchêne M, Seifert K, Obwaller A, Hottkowitz T, Wiedermann G, Eibl H, Aspöck H (2002) Cytotoxic activities of alkylphosphocholines against clinical isolates of Acanthamoeba spp. Antimicrob Agents Chemother 46:695-701 (Pubitemid 34157653)
29. Walochnik J, Obwaller A, Aspock H (2000) Correlations between morphological, molecular biological, and physiological characteristics in clinical and nonclinical isolates of Acanthamoeba spp. Appl Environ Microbiol 66:4408-4413
30. Walochnik J, Obwaller A, Gruber F, Mildner M, Tschachler E, Suchomel M, Duchêne M, Auer H (2009) Anti-Acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent. J Antimicrob Chemother 64:539-545