Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?

Pathology Research and Practice

Volumn 208, Issue 2, 2012, Pages 74-81

  Rios Moreno M J ^a   Jaramillo, S ^a   Pereira Gallardo, S ^a   Vallejo, A ^a   Mora, M ^a   Garcia Escudero A ^a   Amerigo J ^b   Gonzalez Campora R ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^b Hospital Torrecárdernas   (Spain)

Author keywords

CD117; DOG 1; Gastrointestinal stromal tumors (GISTs); PKC

Indexed keywords

DOG 1 PROTEIN; PROTEIN KINASE C DELTA; STEM CELL FACTOR RECEPTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DISEASE MARKER; EXON; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIT GENE; MAJOR CLINICAL STUDY; MALE; PDGFRA GENE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHI-SQUARE DISTRIBUTION; CHLORIDE CHANNELS; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; PARAFFIN EMBEDDING; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SENSITIVITY AND SPECIFICITY; SPAIN; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84856969182     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2011.11.006     Document Type: Article

References (31)

1. Huizinga J.D., Thuneberg L., Kluppel M., et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995, 373:347-349.
2. Miettinen M., Lasota J. Gastrointestinal stromal tumors. Review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch. Pathol. Lab. Med. 2006, 130:1466-1478.
3. Kindblom L.G., Remotti H.E., Aldenborg F., Meis-Kindblom J.M. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am. J. Pathol. 1998, 152:1259-1269.
4. Agaram N.P., Wong G.C., Guo T., Maki R.G., Singer S., DeMatteo R.P., Besmer P., Antonescu C.R. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes Chromosomes Cancer 2008, 47:853-859.
5. Janeway K.A., Zhu M.J., Barretina J., Zhu M.J., Barretina J., Perez-Atayde A., Demetri G.D., Fletcher J.A. Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. Int. J. Cancer 2010, 127:2718-2722.
6. Joensuu H., Roberts P.J., Sarlomo-Rikala M., et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N. Engl. J. Med. 2001, 344:1052-1056.
7. Dematteo R.P., Heinrich M.C., El-Rifai W.M., Demetri G. Clinical management of gastrointestinal tromal tumor: before and after STI-571. Hum. Pathol. 2002, 33:466-477.
8. Fletcher C.D., Berman J.J., Corless C., et al. Diagnosis of gastrointestinalstromal tumors: a consensus approach. Hum. Pathol. 2002, 33:459-465.
9. Medeiros F., Corless C.L., Duensing A., Hornick J.L., Oliveira A.M., Heinrich M.C., Fletcher J.A., Fletcher C.D. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am. J. Surg. Pathol. 2004, 28:889-894.
10. Miettinen M.M., Sobin L.H.L.H., Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod. Pathol. 2000, 13:1134-1142.
11. Miettinen M., Lasota J. Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001, 438:1-12.
12. Debiec-Rychter M., Wasag B., Stul M., et al. Gastrointestinalstromal tumors (GISTs) negative for KIT (CD117 antigen) immunoreactivity. J. Pathol. 2004, 202:430-438.
13. Liegl-Atzwanger B., Fletcher J.A., Fletcher C.D. Gastrointestinal stromal tumors. Virchows Arch. 2010, 456:111-127.
14. Blay P., Astudillo A., Buesa J.M., Campo E., Abad M., García-García J., Miquel R., Marco V., Sierra M., Losa R., Lacave A., Braña A., Balbín M., Freije J.M. Protein kinase c is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. Clin. Cancer Res. 2004, 10:4089-4095.
15. Duensing A., Joseph N.E., Medeiros F., Smith F., Hornick J.L., Heinrich M.C., Corless C.L., Demetri G.D., Fletcher C.D., Fletcher J.A. Protein kinase C (PKC) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). Cancer Res. 2004, 64:5127-5131.
16. Kim K.M., Kang D.W., Moon W.S., Park J.B., Park C.K., Sohn J.H., Jeong J.S., Cho M.Y., Jin S.Y., Choi J.S., Kang D.Y. PKCθ expression in gastrointestinal stromal tumor. Mod. Pathol. 2006, 19:1480-1486.
17. Lee H.E., Kim M.A., Lee H.S., Lee B.L., Kim W.H. Characteristics of KIT-negative gastrointestinal stromal tumors and diagnostic utility of protein kinase C theta immunostaining. J. Clin. Pathol. 2008, 61:722-729.
18. Miettinen M., Wang Z.F., Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors. A study of 1840 cases. Am. J. Surg. Pathol. 2009, 33:1401-1407.
19. Espinosa I., Lee C.H., Kim M.K., Rouse B.T., Subramanian S., Montgomery K., Varma S., Corless C.L., Heinrich M.C., Smith K.S., Wang Z., Rubin B., Nielsen T.O., Seitz R.S., Ross D.T., West R.B., Cleary M.L., van de Rijn M. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am. J. Surg. Pathol. 2008, 32:210-218.
20. Kang G.H., Srivastava A., Kim Y.E., Park H.J., et al. DOG1 and PKCθ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod. Pathol. 2011, 1-10.
21. Liegl B., Hornick J.L., Corless C.L., et al. Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am. J. Surg. Pathol. 2009, 33:437-446.
22. Motegi A., Sakurai S., Nakayama N., Sano T., Oyama T., Nakajima T. PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KITnegative tumors. Pathol. Int. 2005, 55:106-112.
23. Baier G., Telford D., Giampa L., Coggeshall K.M., Baier-Bitterlich G., Isakov N., Altman A. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 1993, 268:4997-5004.
24. Chang J.D., Xu Y., Raychowdhury M.K., Ware J.A. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J. Biol. Chem. 1993, 268:14208-14214.
25. Wilda M., Ghaffari-Tabrizi N., Reisert I., Utermann G., Baier G., Hameister H. Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development. Mech. Dev. 2001, 103:197-200.
26. Southwell B.R.B.R. Localization of protein kinase C immunoreactivity to interstitial cells of Cajal in guinea-pig gastrointestinal tract. Neurogastroenterol. Motil. 2003, 15:139-147.
27. Kang G.H., Kim K.M., Park C.K., et al. PKC-theta expression in Ewing sarcoma/primitive neuroectodermal tumour and malignant peripheral nerve sheath tumour. Histopathology 2009, 55:368-369.
28. Ou W.B., Zhu M.J., Demetri G.D., Fletcher C.D., Fletcher J.A. Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. Oncogene 2008, 27:5624-5634.
29. West R.B., Corless C.L., Chen X., Rubin B.P., Subramanian S., Montgomery K., Zhu S., Ball C.A., Nielsen T.O., Patel R., Goldblum J.R., Brown P.O., Heinrich M.C., van de Rijn M. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am. J. Pathol. 2004, 165:107-113.
30. Caputo A., Caci E., Ferrera L., Pedemonte N., Barsanti C., Sondo E., Pfeffer U., Ravazzolo R., Zegarra-Moran O., Galietta L.J. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 2008, 322:590-594.
31. Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.S., Park S.P., Lee J., Lee B., Kim B.M., Raouf R., Shin Y.K., Oh U.Y.D., Cho H., Koo J.Y.J.Y. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 2008, 455:1210-1215.