Mathematical modeling in immunotherapy of cancer: Personalizing clinical trials

Molecular Therapy

Volumn 20, Issue 1, 2012, Pages 1-2

  Agur, Zvia ^a   Vuk Pavlovi, Stanimir ^b  

^a Institute for Medical Biomathematics Isarel   (Israel)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL (TOPIC); EDITORIAL; HUMAN; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MEDICAL INFORMATION; PERSONALIZED MEDICINE; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; TUMOR IMMUNITY;

EID: 84856967467     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.272     Document Type: Editorial

References (7)

1. Grove, A (2011). Rethinking clinical trials. Science 333: 1679.
2. PriceWaterhouseCoopers (2008). Pharma 2020-Which Path Will You Take? http://www.pwc.be/en/pharma/pdf/Pharma-2020-virtual-rd-PwC-09.pdf
3. Woodcock, J and Woosley, R (2008). The FDA critical path initiative and its influence on new drug development. Annu Rev Med 59: 1-12. (Pubitemid 351287920)
4. Bhattaram, VA, Booth, BP, Ramchandani, RP, Beasley, BN, Wang, Y, Tandon, V et al. (2005). Impact of pharmacometrics on drug approval and labeling decisions: a survey of 42 new drug applications. AAPS J 7: E503-E512.
5. Gorelik, B, Ziv, I, Shohat, R, Wick, M, Hankins, WD, Sidransky, D et al. (2008). Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model. Cancer Res 68: 9033-9040.
6. Michael, A, Ball, G, Quatan, N, Wushishi, F, Russell, N, Whelan, J et al. (2005). Delayed disease progression after allogeneic cell vaccination in hormone-resistant prostate cancer and correlation with immunologic variables. Clin Cancer Res 11: 4469-4478. (Pubitemid 40825637)
7. Kronik, N, Kogan, Y, Elishmereni, M, Halevi-Tobias, K, Vuk-Pavlovic et al. (2010). Predicting outcomes of prostate cancer immunotherapy by personalized mathematical models. PLoS One 5: e15482.