Antiplasmodial, analgesic and anti-inflammatory effects of crude Guiera senegalensis Gmel (Combretaceae) leaf extracts in mice infected with Plasmodium berghei

Journal of Pharmacognosy and Phytotherapy

Volumn 3, Issue 11, 2011, Pages 150-154

  Jigam, Ali A ^a   Akanya, Helmina O ^a   Dauda, Bukar E N ^a   Ogbadoyi, Emmanuel O ^a  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

Author keywords

Analgesic; Anti inflammatory; Antiplasmodial; Antipyretic; Phytochemical

Indexed keywords

ACETYLSALICYLIC ACID; ALKALOID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIMALARIAL AGENT; CHLOROQUINE; FLAVONOID; GLYCOSIDE; GUIERA SENEGALENSIS EXTRACT; PLANT EXTRACT; PYRIMETHAMINE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; COMBRETACEAE; CONTROLLED STUDY; FEMALE; GUIERA SENEGALENSIS; IN VIVO STUDY; LD 50; MALE; MEDICINAL PLANT; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PLANT LEAF; PLASMODIUM BERGHEI INFECTION; PROPHYLAXIS;

EID: 84856966118     PISSN: 21412502     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Abbiw DK (1990). Useful Plants of Ghana. Vol. 1, Kew, Intermediate Technology Publication ltd and Royal Botanic Gardens, pp. 28-34.
2. Bloland PB (2001). Drug resistance in Malaria. Background Document for WHO Global Strategy for Containment of Antimicrobial Resistance. WHO, Switzerland, pp. 3-27.
3. CCAC (1997). Canadian Council on Animal Care Guidelines and Protocol Review.
4. Combier H, Becchi M, Cave A (1977). Traditional Medicinal Uses of G. Senegalensis. Plant Med. Phytother., 11: 251-253.
5. Etkin NL (1997). Antimalarial Plants used by Hausa in Northern Nigeria. Trop. Doctor. 27(Supplementary): 12-16.
6. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S, (2004). Antimalarial drug discovery: efficacy models for compound screening. Supplementary documents. Trends in Parasitol., 14: 18-19.
7. Fletcher E (2007). Traditional remedies-Searching their natural sources for the next malaria drug. TDR news, 79: 8-13.
8. Gamaniel KS (2000). Toxicity from Medicinal Plants and their Products. Nig. J. Nat. Prod. Med., 4: 4-8.
9. Hiermann A, Bucar J (1994). Application of Guiera in African Medicine.J. Ethnopharmacol., 42: 111-116.
10. Haidet A (2003). The medicinal value of the rainforest. Final paper on tropical field courses submitted to the department of Interdisciplinary studies. Miami University, U. S. A.
11. Hutchinson J, Dalziel JM (1965). Flora of West Tropical Part 1, Crown Agents for Oversea Governments and Administrations, London, 1: 275.
12. Jigam AA, Akanya HO, Ogbadoyi EO, Dauda BEN. (2010a). In vivo Antiplasmodial, Analgesic and Antiinflammatory Effects of the Root Extracts of Acacia nilotica Del (Leguminosae). Asian J. Exp. Biol. Sci., 1(2): 315-320.
13. Jigam AA, Akanya HO, Dauda BEN, Okogun JO (2010b). Polygalloyltannin Isolated from the Roots of Acacia nilotica Del (Leguminoseae) is effective against Plasmodium berghei in mice. J. Med. Plants Res., 4(12): 1169-1175.
14. Jigam AA, Akanya HO, Ogbadoyi EO, Dauda BEN and Egwin CE (2009). In vivo Antiplasmodial, analgesic and anti-inflammatory activities of the leaf extract of Lippia multiflora mold. J. Med. Plants Res., 3(3): 148-154.
15. Jigam AA, Atunde WO (2001). Phytochemical and Antimicrobial Activity of Khaya senegalensis. Nig. J. Biochem. Mol. Biol., 16(1): 7-12.
16. Koster R, Anderson M, Debeer EJ (1959). Acetic acid method of analgesic screening. Current Opin. Immunol., 18: 412.
17. Koumare M, Cros J, Pitet G (1968). Chemical Contents of G. senegalensis. Plant Med. Phytother., 2: 204-209.
18. Makkar HPS, Becker K (1994). Chemical Analysis of some Tropical Plant. J. Agric. Food Chem., 42: 731-734.
19. Noedl H, Wongsrichanalai C, Wernsdorfer WH (2003). Malaria drugsensitivity testing: New assays, new perspectives. Trends in Parasitol., 19: 175-181
20. Odebiyi OO, Sofowora EA (1978). Phytochemical Screening of Nigerian Medicinal Plants II. Lloydia 41: 234-235.
21. Okunji CO, Acton N, Ellis WY, Iwu MM (2000). Identification of new antimalarial pharmacophores from West and Central African plants. Proceedings of the International Conference on Traditional Medicine for HIV/AIDS and Malaria. 5th -7th December, 2000. NICON HILTON HOTEL, Abuja Nigeria.
22. Trease GE, Evans WC (1989). Pharmacology.Vol.1. Bailliare Tindal London, pp. 378-480.
23. Winter CA, Risley EA, Nuss GV (1962). Carrageenin induced oedema in hindpaw of rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med., 3: 544-547.
24. World Health Organization (WHO) (2008). Traditional Medicine and Pharmaceutical Medicine. Perspectives of Natural Product for the Treatment of Tropical Diseases WHO/TDR Geneva.
25. Zeljan M, Marica M, Franz B (1998). Flavonoida of G. senegalensis -Thin layer Chromatography and Numerical Methods. Croatica Chemica Acta. 71(1): 69-79.