A potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin

Archives of Toxicology

Volumn 86, Issue 1, 2012, Pages 97-107

  Klarić, Maja Šegvić ^a   Želježić, Davor ^b   Rumora, Lada ^a   Peraica, Maja ^b   Pepeljnjak, Stjepan ^a   Domijan, Ana Marija ^a,c  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

BAPTA AM; Genotoxicity; Mycotoxin synergism; Necrosis; Nephrotoxins

Indexed keywords

CALCIUM; CITRININ; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; OCHRATOXIN; TRYPAN BLUE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL ASSAY; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; IC 50; LABORATORY TEST; MICRONUCLEUS; NONHUMAN; NUCLEAR BUD; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; APOPTOSIS; CALCIUM; CALCIUM SIGNALING; CELL LINE; CELL PROLIFERATION; CHROMATIN; CITRININ; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EPITHELIAL CELLS; INHIBITORY CONCENTRATION 50; KIDNEY; MUTAGENICITY TESTS; NECROSIS; OCHRATOXINS; SWINE; TIME FACTORS;

SUS;

EID: 84856957499     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0735-9     Document Type: Article

References (49)

1. MA Abdel-Wahhab SH Abdel Azim AA El-Nekeety 2008 Inula crithmoides extract protects against ochratoxin A-induced oxidative stress, clastogenic and mutagenic alterations in male rats Toxicon 52 566 573 10.1016/j.toxicon.2008.07. 006 18694774 10.1016/j.toxicon.2008.07.006 1:CAS:528:DC%2BD1cXhtFSqsrjL
2. MD Aleo RD Wyatt RG Schnellmann 1991 The role of altered mitochondrial function in citrinin induced toxicity to rat renal proximal tubule suspension Toxicol Appl Pharmacol 109 455 463 1853344 10.1016/0041-008X(91)90008-3 1:CAS:528:DyaK3MXkvVOiurY%3D
3. H Ammar G Michaelis T Lisowsky 2000 A screen of yeast respiratory mutants for sensitivity against the mycotoxin citrinin identifies the vacuolar the vacuolar ATPase as an essential factor for the toxicity mechanism Curr Genet 37 277 284 10.1007/s002940070001 10853763 10.1007/s002940070001 1:CAS:528:DC%2BD3cXivV2ksL0%3D (Pubitemid 30307339)
4. L Toxicol Sci 79 335 344 10.1093/toxsci/kfh123 15056805 10.1093/toxsci/kfh123 1:CAS:528: DC%2BD2cXkt1SqsLg%3D (Pubitemid 38786891)
5. A Bouslimi C Bouaziz I Ayed-Boussema W Hassen H Bacha 2008 Individual and combined effects of ochratoxin A and citrinin on viability and DNA fragmentation in cultured Vero cells and chromosome abberations in mice bone marrow cells Toxicology 251 1 7 10.1016/j.tox.2008.06.008 18638518 10.1016/j.tox.2008.06.008 1:CAS:528:DC%2BD1cXhtV2jtrjL
6. GM Chagas AP Campello ML Klüppel 1992 Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration enzyme activities and membrane potential of renal cortical mitochondria J Appl Toxicol 12 123 129 1556379 10.1002/jat.2550120209 1:CAS:528:DyaK38XhvV2gurw%3D
7. 2+ transport Cell Biochem Funct 13 53 59 7720190 10.1002/cbf.290130110 1:CAS:528:DyaK2MXktFSitrw%3D
8. EJ Da Lozo MB Oliveira EG Carnieri 1998 Citrinin-induced mitochondrial permeability transition J Biochem Mol Toxicol 12 291 297 10.1002/(SICI)1099- 0461(1998)12:5<291::AID-JBT5>3.0.CO;2-G (Pubitemid 128501123)
9. GH Degen MM Gerber S Obrecht-Pflumio G Dirheimer 1997 Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures Arch Toxicol 71 365 371 9195018 10.1007/s002040050400 1:CAS:528:DyaK2sXjsVCnsr4%3D (Pubitemid 27214469)
10. VV Didenko H Ngo DS Baskin 2003 Presence of blunt-ended DNA breaks, 3′ and 5′ overhangs in apoptosis, but only 5′ overhangs in early necrosis Am J Pathol 162 1571 1578 12707041 10.1016/S0002-9440(10)64291-5 1:CAS:528:DC%2BD3sXjsl2mu7o%3D (Pubitemid 36512840)
11. H Dönmez-Altuntas G Dumlupinar N Imamoglu Z Hamurcu BC Liman 2007 Effects of the mycotoxin citrinin on micronucleus formation in a cytokinesis-block genotoxicity assay in cultured human lymphocytes J Appl Toxicol 27 337 341 10.1002/jat.1209 17265422 10.1002/jat.1209 (Pubitemid 47066761)
12. E Dopp J Müller C Hahnel D Schiffmann 1999 Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian Hamster Embryo (SHE) fibroblasts caused by ochratoxin A Food Chem Toxicol 37 713 721 10496372 10.1016/S0278-6915(99)00057-5 1:CAS:528:DyaK1MXls1Wjt7o%3D (Pubitemid 29397359)
13. S Eder A Benesic R Freudinger J Engert G Schwerdt K Drumm M Gekle 2000 Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells Pflugers Arch 440 521 529 10.1007/s004240000321 10958336 1:CAS:528:DC%2BD3cXls1ajs7o%3D (Pubitemid 30490330)
14. Ehrlich V, Darroudi F, Uhl M, Steinkellner H, Gann M, Majer BJ, Eisenbauer M, Knasmueller S (2002) Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells. Food Chem Toxicol 40:1085-1090. doi: 10.1016/S0278-6915(02)00045-5 (Pubitemid 34626871)
15. M Fenech JW Crott 2002 Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in cytokinesis-block micronucleus assay Mutat Res 504 131 136 10.1016/S0027-5107(02)00086-6 12106653 10.1016/S0027-5107(02)00086-6 1:CAS:528:DC%2BD38XltFaju7k%3D (Pubitemid 34775106)
16. W Föllmann S Lebrun B Kullik M Koch C Römer K Golka 2000 Cytotoxicity of ochratoxin A and citrinin in different cell types in vitro Mycot Res 16 123 126 10.1007/BF02942998
17. EE Golli W Hassen A Bouslimi C Bouaziz MM Ladjimi H Bacha 2006 Induction of Hsp 70 in Vero cells in response to mycotoxins. Cytoprotection by sub-lethal heat shock and by Vitamin E Toxicol Lett 166 122 130 10.1016/j.toxlet.2006.06. 004 16870361 10.1016/j.toxlet.2006.06.004 (Pubitemid 44291962)
18. Grosse Y, Baudrimont I, Castegnaro M, Betbeder AM, Creppy EE, Dirheimer G, Pfohl-Leszkowicz A (1995) Formation of ochratoxin A metabolites and DNA-adducts in monkey kidney. Chem Biol Interact 95:175-187. doi: 10.1016/0009-2797(94)03359-5
19. AH Heussner DR Dietrich E O'Brien 2006 In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells Toxicol In Vitro 20 332 341 10.1016/j.tiv.2005.08.003 16140496 10.1016/j.tiv.2005.08.003 1:CAS:528:DC%2BD28Xit1Cns7o%3D (Pubitemid 43343763)
20. IARC 1986 Some naturally occurring and synthetic food components. Coumarins and ultraviolet radiation IARC Monogr Eval Carcinog Risk Chem Hum 40 14 15
21. IARC 1993 Some naturally occurring substances: heterocyclic aromatic amines and mycotoxins IARC Monogr Eval Carcinog Risk Chem Hum 56 397 444
22. IPCS International Programme on Chemical Safety 2001 Safety evaluation of certain mycotoxins in food WHO Food Addit Ser 47 103 415
23. P Jeswal 1996 Citrinin-induced chromosomal abnormalities in the bone marrow cells of Mus musculus Cytobios 86 29 33 8952057 1:CAS:528: DyaK2sXivFaqsQ%3D%3D (Pubitemid 126490372)
24. Kamp HG, Eisenbrand G, Schlatter J, Würth K, Janzowski C (2005) Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. Toxicology 206:413-425. doi: 10.1016/j.tox.2004.08.004 (Pubitemid 39601026)
25. MM Kogika MK Hagiwara RM Mirandola 1993 Experimental citrinin nephrotoxicosis in dogs: renal function evaluation Vet Hum Toxicol 35 136 140 8470356 1:CAS:528:DyaK3sXit1Oqsrs%3D (Pubitemid 23091273)
26. RA Manderville A Pfohl-Leszkowic 2008 Bioactivation and DNA adduction as a rationale for ochratoxin A carcinogenesis World Mycotoxin J 1 357 367 10.3920/WMJ2008.x039 10.3920/WMJ2008.x039 1:CAS:528:DC%2BD1cXhtFGhu7bK
27. Manolova Y, Manolov G, Parvanova L, Petkova-Bocharova T, Castegnaro M, Chernozemsky IN (1990) Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy. Mutat Res 231:143-149 (Pubitemid 20252547)
28. P Mantle V Faucet-Marquis R Manderville B Sciqualli A Pfohl-Leszkowicz 2010 Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment Chem Res Toxicol 23 89 98 10.1021/tx900295a 19928877 10.1021/tx900295a 1:CAS:528:DC%2BD1MXhsVGntrvM
29. M Marin-Kuan C Cavin T Delatour B Schilter 2008 Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms Toxicon 52 195 202 10.1016/j.toxicon.2008.04.166 18649906 10.1016/j.toxicon.2008.04.166 1:CAS:528:DC%2BD1cXhtVaisrjM
30. MP Mattson SL Chan 2003 Calcium orchestrates apoptosis Nat Cell Biol 5 1041 1043 10.1038/ncb1203-1041 14647298 10.1038/ncb1203-1041 1:CAS:528:DC%2BD3sXptlGnsLk%3D (Pubitemid 37509106)
31. G Müller H Rosner B Rohrmann W Erler G Geschwend U Gräfe B Burkert U Möller R Diller K Sachse H Köhler 2003 Effects of the mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1 Toxicology 148 69 82 10.1016/S0300-483X(02)00593-0 10.1016/S0300-483X(02)00593-0 (Pubitemid 36009309)
32. Petkova-Bocharova T, Castegnaro M, Michelon J, Maru V (1991) Ochratoxin A and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria. In: Castegnaro M, Pleština R, Driheimer G, Chernozemsky IN, Bartsch H (eds) Mycotoxiny, endemic nephropathy and urinary tract tumours, vol 115. IARC Scientific Publications, Lyon, pp 83-87
33. E Pfeiffer K Groβ M Metzler 1998 Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin Carcinogenesis 19 1313 1318 9683194 10.1093/carcin/19.7.1313 1:CAS:528:DyaK1cXkvV2gsLc%3D (Pubitemid 28375385)
34. A Pfohl-Leszkowicz 2009 Ochratoxin A and aristolochic acid in the nephropathies and associated urothelial tract tumours development Arh Hig Rada Toksikol 60 465 483 10.2478/10004-1254-60-2009-2000 20061248 10.2478/10004-1254-60-2009-2000 1:CAS:528:DC%2BC3cXhslKhurY%3D
35. A Pfohl-Leszkowicz RA Manderville 2007 Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans Mol Nutr Food Res 51 61 99 10.1002/mnfr.200600137 17195275 10.1002/mnfr.200600137 1:CAS:528: DC%2BD2sXhtFCrurw%3D
36. A Pfohl-Leszkowicz M Tozlovanu R Manderville M Peraica M Castegnaro V Stefanovic 2007 New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor Mol Nutr Food Res 51 1131 1146 10.1002/mnfr.200700045 17729220 10.1002/mnfr.200700045 1:CAS:528:DC%2BD2sXhtFOnu73E (Pubitemid 47522807)
37. Pfohl-Leszkowicz A, Molinié A, Tozlovanu M, Manderville RA (2008) Combined toxic effects of ochratoxin A and citrinin, in vitro and in vivo. In: Siantar DP, Trucksess MW, Scott PM, Herman EM (eds) Food contaminants, mycotoxins and food allergen. American Chemical Society, Washington DC, pp 56-80
38. Rahimtula AD, Chong X (1991) Alterations in calcium homeostasis as a possible cause of ochratoxin A nephrotoxicity. In: Castegnaro M, Pleština R, Driheimer G, Chernozemsky IN, Bartsch H (eds) Mycotoxiny, endemic nephropathy and urinary tract tumours (IARC Scientific Publications No. 115). IARC Press, Lyon, pp 207-214
39. SM Ribeiro GM Chagas AP Campello ML Kluppel 1997 Mechanism of citrinin-induced dysfunction of mitochondria V. Effect on the homeostasis of the reactive oxygen species Cell Biochem Funct 15 203 209 9377799 10.1002/(SICI)1099-0844(199709)15:3<203::AID-CBF742>3.0.CO;2-J 1:CAS:528:DyaK2sXmtVKgtbw%3D (Pubitemid 27395287)
40. G Schwerdt R Freudinger C Schuster S Silbernagl M Gekle 2004 Inhibition of mitochondria and extracellular acidification enhance ochratoxin A-induced apoptosis in renal collecting duct-derived MDCK-C7 cells Cell Physiol Biochem 14 47 56 10.1159/000076926 14976406 10.1159/000076926 1:CAS:528: DC%2BD2cXhtlygurs%3D (Pubitemid 38269823)
41. 1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment Croat Chem Acta 81 139 146
42. M Šegvić Klarić D Daraboš R Rozgaj V Kašuba S Pepeljnjak 2010 Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action Arch Toxicol 84 641 650 10.1007/s00204-010-0535-7 10.1007/s00204-010-0535-7
43. GJA Speijers MHM Speijers 2004 Combined toxic effects of mycotoxins Toxicol Lett 153 91 98 10.1016/j.toxlet.2004.04.046 15342085 10.1016/j.toxlet.2004.04.046 1:CAS:528:DC%2BD2cXntlGltL4%3D (Pubitemid 39165753)
44. R Thust S Kneist 1979 Activity of citrinin metabolized by rat and human microsome fraction in clastogenicity and SCE assay on Chinese hamster V79-E cells Mutat Res 67 321 330 481457 10.1016/0165-1218(79)90028-4 1:CAS:528:DyaE1MXls12murs%3D (Pubitemid 9250917)
45. T Vrabcheva E Usleber R Dietrich E Maärtlbauer 2000 Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy J Agric Food Chem 48 2483 2488 10.1021/jf990891y 10888572 10.1021/jf990891y 1:CAS:528:DC%2BD3cXjtlygtL4%3D (Pubitemid 30431262)
46. F Weber R Freudinger G Schwerdt M Gekle 2005 A rapid screening method to test apoptotic synergisms of ochratoxin A with other nephrotoxic substances Toxicol In Vitro 19 135 143 10.1016/j.tiv.2004.08.002 15582364 10.1016/j.tiv.2004.08.002 1:CAS:528:DC%2BD2cXhtVCgt7jI (Pubitemid 39592985)
47. FE Würgler U Friederich J Schlatter 1991 Lack of mutagenicity of ochratoxin Aand B, citrinin, patulin and cnestine in Salmonella typhimurium TA 102 Mutat Res 261 209 216 1719413 10.1016/0165-1218(91)90069-X
48. F-Y Yu Y-C Liao C-H Chang B-H Liu 2006 Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway Toxicol Lett 161 143 151 101016/j.toxlet.2005.08.009 16183218 10.1016/j.toxlet.2005.08.009 1:CAS:528:DC%2BD2MXhtlWqtLvI (Pubitemid 41790287)
49. D Želježić A-M Domijan M Peraica 2006 DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay Braz J Med Biol Res 39 1563 1568 10.1590/S0100-879X2006005000029 17160264 10.1590/S0100- 879X2006005000029 (Pubitemid 46357841)