CRP 1846G>A polymorphism increases risk of frailty

Maturitas

Volumn 71, Issue 3, 2012, Pages 261-266

  Almeida, Osvaldo P ^a,b,c   Norman, Paul E ^b   Van Bockxmeer, Frank M ^b   Hankey, Graeme J ^c,d   Flicker, Leon ^a,c,d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c ROYAL PERTH HOSPITAL   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Allostasis; Elderly; Frailty; Genetics; Inflammation

Indexed keywords

C REACTIVE PROTEIN;

AGED; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FATIGUE; FRAILTY; GENERAL ASPECTS OF DISEASE; GENETIC RISK; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; SYNDROME; WEIGHT REDUCTION; WILD TYPE;

AGED; AGED, 80 AND OVER; AUSTRALIA; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; FRAIL ELDERLY; HUMANS; LIFE STYLE; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84856956398     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2011.11.022     Document Type: Article

References (31)

1. L.P. Fried, Q.L. Xue, and A.R. Cappola Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment J Gerontol A: Biol Sci Med Sci 64 2009 1049 1057
2. K. Rockwood, S.E. Howlett, and C. MacKnight Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging J Gerontol A: Biol Sci Med Sci 59 2004 1310 1317 (Pubitemid 40209418)
3. G.P. Chrousos, and P.W. Gold The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis JAMA 267 1992 1244 1252
4. B.S. McEwen Stress, adaptation, and disease. Allostasis and allostatic load Ann NY Acad Sci 840 1998 33 44 (Pubitemid 28302033)
5. B.S. McEwen Protective and damaging effects of stress mediators New Engl J Med 338 1998 171 179
6. S. Black, I. Kushner, and D. Samols C-reactive protein J Biol Chem 279 2004 48487 48490 (Pubitemid 39625721)
7. R.E. Hubbard, M.S. O'Mahony, B.L. Calver, and K.W. Woodhouse Plasma esterases and inflammation in ageing and frailty Eur J Clin Pharmacol 64 2008 895 900
8. M.T. Puts, M. Visser, J.W. Twisk, D.J. Deeg, and P. Lips Endocrine and inflammatory markers as predictors of frailty Clin Endocrinol (Oxf) 63 2005 403 411 (Pubitemid 41442334)
9. J.E. Volanakis Human C-reactive protein: expression, structure, and function Mol Immunol 38 2001 189 197 (Pubitemid 32786776)
10. F.A. Robey, K.D. Jones, and A.D. Steinberg C-reactive protein mediates the solubilization of nuclear DNA by complement in vitro J Exp Med 161 1985 1344 1356 (Pubitemid 15046034)
11. M.H. Kaplan, and J.E. Volanakis Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin J Immunol 112 1974 2135 2147
12. L.L. Marnell, C. Mold, M.A. Volzer, R.W. Burlingame, and T.W. Du Clos C-reactive protein binds to Fc gamma RI in transfected COS cells J Immunol 155 1995 2185 2193
13. D.C. Crawford, C.L. Sanders, and X. Qin Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey Circulation 114 2006 2458 2465 (Pubitemid 44901518)
14. L.A. Lange, C.S. Carlson, and L.A. Hindorff Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events JAMA 296 2006 2703 2711 (Pubitemid 44917547)
15. C. Verzilli, T. Shah, and J.P. Casas Bayesian meta-analysis of genetic association studies with different sets of markers Am J Hum Genet 82 2008 859 872
16. D.J. Brull, N. Serrano, and F. Zito Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease Arterioscler Thromb Vasc Biol 23 2003 2063 2069 (Pubitemid 37433201)
17. O.P. Almeida, P.E. Norman, and R. Allcock Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study Int J Epidemiol 38 2009 1049 1059
18. P.E. Norman, L. Flicker, O.P. Almeida, G.J. Hankey, Z. Hyde, and K. Jamrozik Cohort profile: the Health in Men Study (HIMS) Int J Epidemiol 38 2009 48 52
19. G. Abellan van Kan, Y.M. Rolland, J.E. Morley, and B. Vellas Frailty: toward a clinical definition J Am Med Dir Assoc 9 2008 71 72 (Pubitemid 351189169)
20. G. Abellan van Kan, Y. Rolland, H. Bergman, J.E. Morley, S.B. Kritchevsky, and B. Vellas The I.A.N.A. task force on frailty assessment of older people in clinical practice J Nutr Health Aging 12 2008 29 37 (Pubitemid 351156012)
21. J.E. Ware, M. Kosinski, and B. Gandek SF-36 Health Survey: manual & interpretation guide 2000 QualityMetric Incorporated Lincoln, RI
22. Z. Hyde, L. Flicker, and O.P. Almeida Low free testosterone predicts frailty in older men: the Health in Men Study J Clin Endocrinol Metab 95 2010 3165 3172
23. Lopez D, Flicker L, Dobson A. Validation of the FRAIL scale in a cohort of older Australian women. J Am Geriatr Soc; in press.
24. ABS National Health Survey: SF-36 population norms, Australia 1995 Australian Bureau of Statistics Canberra
25. T.A. Pearson, G.A. Mensah, and R.W. Alexander Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association Circulation 107 2003 499 511 (Pubitemid 36158056)
26. C.S. Carlson, S.F. Aldred, and P.K. Lee Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels Am J Hum Genet 77 2005 64 77 (Pubitemid 40848037)
27. N.J. Timpson, D.A. Lawlor, and R.M. Harbord C-reactive protein and its role in metabolic syndrome: mendelian randomisation study Lancet 366 2005 1954 1959 (Pubitemid 41713985)
28. J. Danesh, J.G. Wheeler, and G.M. Hirschfield C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease New Engl J Med 350 2004 1387 1397 (Pubitemid 38419992)
29. O.P. Almeida, B.B. Yeap, G.J. Hankey, K. Jamrozik, and L. Flicker Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men Arch Gen Psychiatry 65 2008 283 289 (Pubitemid 351342444)
30. L.P. Fried, C.M. Tangen, and J. Walston Frailty in older adults: evidence for a phenotype J Gerontol A: Biol Sci Med Sci 56 2001 M146 M156
31. B.S. McEwen Protective and damaging effects of stress mediators: central role of the brain Dialogues Clin Neurosci 8 2006 367 381 (Pubitemid 46102239)