-
1
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of phase I study of navitoclax in patients with relapsed or refractory disease
-
Roberts AW, Seymour JF, Brown JR, et al: Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 30:488-496, 2012
-
(2012)
J Clin Oncol
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
-
2
-
-
77952952903
-
The role of Bcl-2 family proteins in chronic lymphocytic leukaemia
-
Buggins AG, Pepper CJ: The role of Bcl-2 family proteins in chronic lymphocytic leukaemia. Leuk Res 34:837-842, 2010
-
(2010)
Leuk Res
, vol.34
, pp. 837-842
-
-
Buggins, A.G.1
Pepper, C.J.2
-
3
-
-
20044372326
-
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
-
DOI 10.1172/JCI200523409
-
Messmer BT, Messmer D, Allen SL, et al: In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 115:755-764, 2005 (Pubitemid 40322252)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.3
, pp. 755-764
-
-
Messmer, B.T.1
Messmer, D.2
Allen, S.L.3
Kolitz, J.E.4
Kudalkar, P.5
Cesar, D.6
Murphy, E.J.7
Koduru, P.8
Ferrarini, M.9
Zupo, S.10
Cutrona, G.11
Damle, R.N.12
Wasil, T.13
Rai, K.R.14
Hellerstein, M.K.15
Chiorazzi, N.16
-
4
-
-
32944475363
-
Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia
-
DOI 10.1200/JCO.2005.02.4364
-
O'Brien SM, Cunningham CC, Golenkov AK, et al: Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J Clin Oncol 23:7697-7702, 2005 (Pubitemid 46291834)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.30
, pp. 7697-7702
-
-
O'Brien, S.M.1
Cunningham, C.C.2
Golenkov, A.K.3
Turkina, A.G.4
Novick, S.C.5
Rai, K.R.6
-
5
-
-
58849164097
-
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Claxton DF, Crump M, et al: Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 113:299-305, 2009
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'Brien, S.M.1
Claxton, D.F.2
Crump, M.3
-
6
-
-
0030048565
-
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
-
Panayiotidis P, Jones D, Ganeshaguru K, et al: Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol 92:97-103, 1996 (Pubitemid 26018774)
-
(1996)
British Journal of Haematology
, vol.92
, Issue.1
, pp. 97-103
-
-
Panayiotidis, P.1
Jones, D.2
Ganeshaguru, K.3
Foroni, L.4
Hoffbrand, A.V.5
-
7
-
-
0026696155
-
Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells
-
Schena M, Larsson LG, Gottardi D, et al: Growth- and differentiation- associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood 79:2981-2989, 1992
-
(1992)
Blood
, vol.79
, pp. 2981-2989
-
-
Schena, M.1
Larsson, L.G.2
Gottardi, D.3
-
8
-
-
78649792807
-
The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia
-
Packham G, Stevenson F: The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia. Semin Cancer Biol 20:391-399, 2010
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 391-399
-
-
Packham, G.1
Stevenson, F.2
-
9
-
-
77957201023
-
Phosphatidylinositol 3-kinase-δinhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al: Phosphatidylinositol 3-kinase-δinhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 116:2078-2088, 2010
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
10
-
-
84872213122
-
CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110 delta, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
-
Presented at abstr 55
-
Furman RR, Byrd JC, Brown JR, et al: CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110 delta, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. Presented at ASH Annual Meeting, Orlando, FL, December 4-7, 2010 (abstr 55)
-
ASH Annual Meeting, Orlando, FL, December 4-7, 2010
-
-
Furman, R.R.1
Byrd, J.C.2
Brown, J.R.3
-
11
-
-
79959404661
-
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
-
Herman SE, Gordon AL, Hertlein E, et al: Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 117:6287-6296, 2011
-
(2011)
Blood
, vol.117
, pp. 6287-6296
-
-
Herman, S.E.1
Gordon, A.L.2
Hertlein, E.3
-
12
-
-
84856858792
-
The Bruton's tyrosine kinase inhibitor, PCI-32765, is well tolerated and demonstrates promising clinical activity in chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): An update on ongoing phase 1 studies
-
Presented at abstr 57
-
Burger JA, O'Brien S, Fowler N, et al: The Bruton's tyrosine kinase inhibitor, PCI-32765, is well tolerated and demonstrates promising clinical activity in chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): An update on ongoing phase 1 studies. Presented at ASH Annual Meeting, Orlando, FL, December 4-7, 2010 (abstr 57)
-
ASH Annual Meeting, Orlando, FL, December 4-7, 2010
-
-
Burger, J.A.1
O'Brien, S.2
Fowler, N.3
-
13
-
-
33947243663
-
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
-
DOI 10.1200/JCO.2005.05.0401
-
Chanan-Khan A, Miller KC, Musial L, et al: Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study. J Clin Oncol 24:5343-5349, 2006 (Pubitemid 46623164)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.34
, pp. 5343-5349
-
-
Chanan-Khan, A.1
Miller, K.C.2
Musial, L.3
Lawrence, D.4
Padmanabhan, S.5
Takeshita, K.6
Porter, C.W.7
Goodrich, D.W.8
Bernstein, Z.P.9
Wallace, P.10
Spaner, D.11
Mohr, A.12
Byrne, C.13
Hernandez-Ilizaliturri, F.14
Chrystal, C.15
Starostik, P.16
Czuczman, M.S.17
-
14
-
-
84855463714
-
Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia
-
abstr 0772
-
Andritsos LA, Byrd JC, Hewes B, et al: Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia. Haematologica 95:321, 2010 (suppl 2; abstr 0772)
-
(2010)
Haematologica
, vol.95
, Issue.SUPPL. 2
, pp. 321
-
-
Andritsos, L.A.1
Byrd, J.C.2
Hewes, B.3
-
15
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz T, Eichhorst B, Busch R, et al: TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 28:4473-4479, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 4473-4479
-
-
Zenz, T.1
Eichhorst, B.2
Busch, R.3
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