Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1346-1359

  Mao, Yongjun ^a,b   Lin, Nan ^a,b   Tian, Wang ^a,b   Han, Xiaofeng ^a,b   Han, Xiaobing ^a,b   Huang, Ziwei ^a,b   An, Jing ^a,b  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; 4 FLUORO N [4 [[[2 (4 METHYLPIPERAZIN 1 YL)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]BENZAMIDE; 4 FLUORO N [4 [[[2 (DIMETHYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]BENZAMIDE; 4 FLUORO N [4 [[[2 (ETHYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]BENZAMIDE; 4 FLUORO N [4 [[[2 (METHYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]BENZAMIDE; 4 FLUORO N [4 [[[2 (PROPYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]BENZAMIDE; ANTINEOPLASTIC AGENT; BETA CATENIN; N (2 PHENYLCYCLOPROPYL) 4 [[[2 (DIMETHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (2 PHENYLCYCLOPROPYL) 4 [[[2 (ETHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROBENZYL) 4 [[[2 (3 METHYLPIPERAZIN 1 YL) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROBENZYL) 4 [[[2 (DIMETHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROBENZYL) 4 [[[2 (PROPYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENETHYL) 4 [[[2 (DIMETHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENETHYL) 4 [[[2 (METHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENETHYL) 4 [[[2 (PROPYLAMINO) 6 METHYLQUINANAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENYL) 4 [[[2 (ALLYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENYL) 4 [[[2 (BUTYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N (4 FLUOROPHENYL) 4 [[[2 (PROPYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N [1 (4 FLUOROBENZOYL)PIPERIDIN 4 YL] 4 [[[2 (ALLYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N [1 (4 FLUOROBENZOYL)PIPERIDIN 4 YL] 4 [[[2 (PROPYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N [1 (4 FLUOROBENZYL)PIPERIDIN 4 YL] 4 [[[2 (METHYLAMINO) 6 METHYLQUINAZOLIN 4 YL]AMINO]METHYL]BENZAMIDE; N [4 [[[2 (4 METHYLPIPERAZIN 1 YL)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]ISONICOTINAMIDE; N [4 [[[2 (DIMETHYLAMINO)QUINAZOLIN 4 YL)AMINO]METHYL]PHENYL]ISONICOTINAMIDE; N [4 [[[2 (METHYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL] 4 [(4 METHYLPIPERAZIN 1 YL)METHYL]BENZAMIDE; N [4 [[[2 (METHYLAMINO)QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL]ISONICOTINAMIDE; N [4 [[[2 [3 (DIMETHYLAMINO)PROPYLAMINO]QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL] 4 [(4 METHYLPIPERAZIN 1 YL)METHYL]BENZAMIDE; N [4 [[[2 [3 (DIMETHYLAMINO)PROPYLAMINO]QUINAZOLIN 4 YL]AMINO]METHYL]PHENYL] 4 FLUOROBENZAMIDE; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, REPORTER; HUMANS; LUCIFERASES; MODELS, MOLECULAR; QUINAZOLINES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84856941656     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201494a     Document Type: Article

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