Development and validation of rp-hplc method for quantitation of amoxicillin trihydrate in bulk and pharmaceutical formulations using box-behnken experimental design

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 3, 2012, Pages 393-406

  Beg, Sarwar ^a   Kohli, Kanchan ^a   Swain, Suryakanta ^b   Hasnain, M Saquib ^c  

^a HAMDARD UNIVERSITY   (India)

^b SEEMANTA INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^c Roland Institute of Pharmaceutical Sciences   (India)

Author keywords

amoxicillin trihydrate; experimental design; HPLC; linearity; robustness; validation

Indexed keywords

AMOXICILLIN; BOX-BEHNKEN EXPERIMENTAL DESIGN; BULK DRUGS; CHROMATOGRAPHIC SEPARATIONS; HPLC; ISOCRATIC ELUTION; LINEARITY; MOBILE PHASE; MOBILE-PHASE COMPOSITION; PEAK AREA; PHARMACEUTICAL FORMULATION; PHOSPHATE BUFFERS; RETENTION TIME; ROBUSTNESS TESTING; ROUTINE ANALYSIS; RP-HPLC METHOD; UV DETECTION; VALIDATION;

DESIGN OF EXPERIMENTS; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; METHANOL; PH EFFECTS; ROBUSTNESS (CONTROL SYSTEMS); STATISTICS;

DRUG PRODUCTS;

AMOXICILLIN; ANTIBIOTIC AGENT; CEFADROXIL; DAMOXY; UNCLASSIFIED DRUG;

ACCURACY; ANTIBIOTIC THERAPY; ARTICLE; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; FLOW RATE; HUMAN; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION; VALIDATION STUDY;

EID: 84856939830     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.601493     Document Type: Article

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