Negamycin analogue with readthrough-promoting activity as a potential drug candidate for Duchenne muscular dystrophy

ACS Medicinal Chemistry Letters

Volumn 3, Issue 2, 2012, Pages 118-122

  Taguchi, Akihiro ^a   Nishiguchi, Shigenobu ^b   Shiozuka, Masataka ^c   Nomoto, Takao ^a   Ina, Mayuko ^a   Nojima, Shouta ^a   Matsuda, Ryoichi ^c   Nonomura, Yoshiaki ^c,d   Kiso, Yoshiaki ^b   Yamazaki, Yuri ^a   Yakushiji, Fumika ^a   Hayashi, Yoshio ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

Duchenne muscular dystrophy; genetic disease; hydrazino dipeptide; Negamycin; nonsense mutations; readthrough promoting activity

Indexed keywords

CREATINE KINASE; DYSTROPHIN; GENE THERAPY AGENT; NEGAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG READTHROUGH PROMOTING ACTIVITY; DRUG SYNTHESIS; DRUG TOXICITY; DUCHENNE MUSCULAR DYSTROPHY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

MUS;

EID: 84856913604     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200245t     Document Type: Article

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