Function of the acrosomal matrix: Zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization

Biology of Reproduction

Volumn 86, Issue 1, 2012, Pages

  Muro, Yuko ^a,b   Buffone, Mariano G ^c   Okabe, Masaru ^a   Gerton, George L ^d  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Acrosome; Acrosome reaction; Fertilization; Sperm; Zona pellucida

Indexed keywords

CALCIUM IONOPHORE; MATRIX PROTEIN; UNCLASSIFIED DRUG; ZONA PELLUCIDA 3 RECEPTOR; CELL SURFACE RECEPTOR; SP56 PROTEIN, MOUSE;

ACROSOME; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXOCYTOSIS; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; GENE DELETION; HETEROZYGOTE; HOMOLOGOUS RECOMBINATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; LITTER SIZE; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS WEIGHT; WILD TYPE; ZONA PELLUCIDA; ACROSOME REACTION; ANIMAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HISTOLOGY; METABOLISM; PHYSIOLOGY; SPERMATOZOON; TESTIS;

ANIMALIA; MAMMALIA; MUS;

ACROSOME; ACROSOME REACTION; ANIMALS; FEMALE; FERTILIZATION; GENE EXPRESSION REGULATION; MALE; MICE; RECEPTORS, CELL SURFACE; SPERMATOZOA; TESTIS;

EID: 84856907447     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.095877     Document Type: Article

References (30)

1. Tulsiani DR, Yoshida-Komiya H, Araki Y. Mammalian fertilization: a carbohydrate-mediated event. Biol Reprod 1997; 57:487-494.
2. Clark GF. Molecular models for mouse sperm-oocyte binding. Glycobiology 2011; 21:3-5.
3. Wassarman PM. Zona pellucida glycoproteins. J Biol Chem 2008; 283:24285-24289.
4. Baba T, Azuma S, Kashiwabara S, Toyoda Y. Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization. J Biol Chem 1994; 269:31845-31849.
5. Lu Q, Shur BD. Sperm from beta-1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development 1997; 124:4121-4131.
6. Ensslin MA, Shur BD. Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding. Cell 2003; 114:405-417.
7. Primakoff P, Hyatt H, Myles DG. A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida. J Cell Biol 1985; 101:2239-2244.
8. Tardif S, Wilson MD, Wagner R, Hunt P, Gertsenstein M, Nagy A, Lobe C, Koop BF, Hardy DM. Zonadhesin is essential for species specificity of sperm adhesion to the egg's zona pellucida. J Biol Chem 2010; 285:24863-24870.
9. Cheng A, Le T, Palacios M, Bookbinder LH, Wassarman PM, Suzuki F, Bleil JD. Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3. J Cell Biol 1994; 125:867-878.
10. Bleil JD, Wassarman PM. Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking. Proc Natl Acad Sci U S A 1990; 87:5563-5567.
11. Buffone MG, Foster JA, Gerton GL. The role of the acrosomal matrix in fertilization. Int J Dev Biol 2008; 52:511-522.
12. Foster JA, Friday BB, Maulit MT, Blobel C, Winfrey VP, Olson GE, Kim KS, Gerton GL. AM67, a secretory component of the guinea pig sperm acrosomal matrix, is related to mouse sperm protein sp56 and the complement component 4-binding proteins. J Biol Chem 1997; 272:12714-12722.
13. Kim KS, Cha MC, Gerton GL. Mouse sperm protein sp56 is a component of the acrosomal matrix. Biol Reprod 2001; 64:36-43.
14. Kim K-S, Gerton GL. Differential release of soluble and matrix components: evidence for intermediate states of secretion during spontaneous acrosomal exocytosis in mouse sperm. Dev Biol 2003; 264:141-152.
15. Buffone MG, Kim K-S, Doak BJ, Rodriguez-Miranda E, Gerton GL. Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix. J Cell Sci 2009; 122:3153-3160.
16. He XB, Yan YC, Li YP, Koide SS. Cloning of rat sp56, the homologue of mouse sperm ZP3 receptor-sp56. Cell Res 2003; 13:121-129.
17. Rohlfs RV, Swanson WJ, Weir BS. Detecting coevolution through allelic association between physically unlinked loci. Am J Hum Genet 2010; 86:674-685.
18. Inoue N, Ikawa M, Isotani A, Okabe M. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 2005; 434(7030):234-238.
19. Liu P, Jenkins NA, Copeland NG. A highly efficient recombineeringbased method for generating conditional knockout mutations. Genome Res 2003; 13:476-484.
20. Yamaguchi R, Yamagata K, Ikawa M, Moss SB, Okabe M. Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice. Biol Reprod 2006; 75:760-766.
21. Toyoda Y, Yokoyama M, Hosi T. Studies on the fertilization of mouse eggs in vitro. I. In vitro fertilization of eggs by fresh epididymal sperm. Jpn J Anim Reprod 1971; 16:147-151.
22. Nakanishi T, Ikawa M, Yamada S, Parvinen M, Baba T, Nishimune Y, Okabe M. Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein. FEBS Lett 1999; 449:277-283.
23. Ikawa M, Wada I, Kominami K, Watanabe D, Toshimori K, Nishimune Y, Okabe M. The putative chaperone calmegin is required for sperm fertility. Nature 1997; 387(6633):607-611.
24. Dean J. The enigma of sperm-egg recognition in mice. Soc Reprod Fertil Suppl 2007; 63:359-365.
25. Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science 2010; 329(5988):216-219.
26. Visconti PE, Florman HM. Mechanisms of sperm-egg interactions: between sugars and broken bonds. Sci Signal 2010; 3(142):pe35.
27. Bookbinder LH, Cheng A, Bleil JD. Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science 1995; 269(5220):86-89.
28. Buffone MG, Zhuang T, Ord TS, Hui L, Moss SB, Gerton GL. Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro. J Biol Chem 2008; 283:12438-12445.
29. Inoue N, Ikawa M, Nakanishi T, Matsumoto M, Nomura M, Seya T, Okabe M. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol Cell Biol 2003; 23:2614-2622.
30. Jin M, Fujiwara E, Kakiuchi Y, Okabe M, Satouh Y, Baba SA, Chiba K, Hirohashi N. Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization. Proc Natl Acad Sci U S A 2011; 108:4892-4896.